Mon, Apr 21, 2025
Sharabeh Hezarkhani1 
, Khosro Ghojoghi2 , Sara Hosseinzadeh2 , Naser Behnampour3 , Farshid Fathabadi2 , Zahra Hesari4 , Hamid Reza Joshaghani2
, Khosro Ghojoghi2 , Sara Hosseinzadeh2 , Naser Behnampour3 , Farshid Fathabadi2 , Zahra Hesari4 , Hamid Reza Joshaghani2
1- Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran , hezarkhani@goums.ac.ir
2- Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran
3- Biostatistics Department, Faculty of Health, Golestan University of Medical Sciences, Gorgan, Iran.
4- Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran
2- Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran
3- Biostatistics Department, Faculty of Health, Golestan University of Medical Sciences, Gorgan, Iran.
4- Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran
Abstract: (596 Views)
Background and aims: Leptin and adiponectin, two members of Adipokines, increase lipid metabolism and inhibit lipogenesis. Reduced levels of these cytokines associate to obesity and insulin resistance. Thus, the serum levels of leptin and adiponectin were determined in type-2 diabetic patients with and without metabolic syndrome in comparison to the control group.
Material and methods: Three groups of individuals were involved in this study; 47 type-2 diabetic patients with metabolic syndrome (DM+MetS), 25 type-2 diabetic patients without metabolic syndrome (DM-MetS), and 40 control group with no history of diabetes and metabolic syndrome as control group. Fasting blood samples were collected and the serum levels of fasting blood sugar (FBS), cholesterol, triglyceride, HDL-Cholesterol and LDL-Cholesterol were measured by the enzymatic method; blood pressure, body height and weight with stadiometers; leptin and adiponectin by the enzyme-linked immunosorbent assay.
Results: There was a significant difference among the groups in serum leptin(p=0.004) and adiponectin(p=0.000) levels. In patients with type-2 diabetes and metabolic syndrome, serum leptin (p=0.530) and adiponectin(p=0.000) were lower in comparison to the control group.
Conclusion: A decrease in the serum level of important adipokines such as leptin and adiponectin in type-2 diabetic patients can be a predictor of metabolic syndrome.
Material and methods: Three groups of individuals were involved in this study; 47 type-2 diabetic patients with metabolic syndrome (DM+MetS), 25 type-2 diabetic patients without metabolic syndrome (DM-MetS), and 40 control group with no history of diabetes and metabolic syndrome as control group. Fasting blood samples were collected and the serum levels of fasting blood sugar (FBS), cholesterol, triglyceride, HDL-Cholesterol and LDL-Cholesterol were measured by the enzymatic method; blood pressure, body height and weight with stadiometers; leptin and adiponectin by the enzyme-linked immunosorbent assay.
Results: There was a significant difference among the groups in serum leptin(p=0.004) and adiponectin(p=0.000) levels. In patients with type-2 diabetes and metabolic syndrome, serum leptin (p=0.530) and adiponectin(p=0.000) were lower in comparison to the control group.
Conclusion: A decrease in the serum level of important adipokines such as leptin and adiponectin in type-2 diabetic patients can be a predictor of metabolic syndrome.
Research Article: Research Article |
Subject:
Biochemistry
Received: 2024/08/8 | Accepted: 2024/11/12
Received: 2024/08/8 | Accepted: 2024/11/12
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