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OUTBREAK OF BURKHOLDERIA GLADIOLI: AN “ALARMING PERIL” CAUSING SEPTICEMIA IN NEONATAL INTENSIVE CARE UNIT: A RARE STUDY
Karvi Agarwal1 , Naila Begum2 , Konpal Agarwal3
1- assistant professor
2- SENIOR RESIDENT , naila.1668@gmail.com
3- junior resident
Abstract:   (549 Views)
OBJECTIVES:  To investigate the outbreak in the NICU of a tertiary care hospital in western UP in India and to know the source of infection by doing root cause analysis, study the clinical profiles and outcomes of neonates with Burkholderia gladioli septicemia, to determine the antimicrobial susceptibility pattern of these isolates and to take adequate CAPA.
METHODOLOGY: During the month of January 2024, multiple Burkholderia gladioli isolates with similar AST pattern were isolated from blood cultures of babies admitted to NICU of our hospital. An outbreak was suspected with mortality rate of 57.1%. The NICU in-charge and HIC team were alerted to follow up the patients and to investigate this outbreak for CAPA and RCA. Environmental Surveillance was done for NICU. Burkholderia gladioli was successfully isolated from suction apparatus and phototherapy units as confirmed by Automated BD Phoenix System.
RESULTS: Out of 72, 34 bottles signaled/flagged positive for microbial growth, with positivity rate of 47.2%. Among the positive cultures, Burkholderia gladioli were isolated from seven different patients, contributing to major percentage of 20.6% of total positivity. The Identification and Antimicrobial susceptibility testing were performed by Automated BD Phoenix system
CONCLUSION: This outbreak investigation raises the concern regarding the potential severity of Burkholderia gladioli septicemia in NICU set up and the need to broaden clinicians' suspicion for this rare bug. Rapid identification of the outbreak, defining the source and taking appropriate infection control measures to control the outbreak are the key points in managing and improving the neonatal outcome.
 
Keywords: Burkholderia gladioli Outbreak, Septicemia, NICU (neonatal intensive care unit), Hospital infection control (HIC), CAPA (corrective Action Preventive Action), RCA (Root cause analysis), Environmental Surveillance
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Research Article: Research Article | Subject: bacteriology
Received: 2024/04/25 | Accepted: 2026/06/6
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