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mljgoums 2024, 18(4): 14-16 |
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Subrat S, Prasad M L, Varshney K, Bansal K, Mahajan M, Chowdhury A. A study of prognostic significance of serum magnesium and serum potassium levels in acute stroke. mljgoums 2024; 18 (4) :14-16
URL: http://mlj.goums.ac.ir/article-1-1750-en.html
URL: http://mlj.goums.ac.ir/article-1-1750-en.html
Sudhanshu Subrat1 
, Manohar Lal Prasad2 , Kavya Varshney3 , Kanika Bansal4 , Mayank Mahajan5 , Anindya Chowdhury1
, Manohar Lal Prasad2 , Kavya Varshney3 , Kanika Bansal4 , Mayank Mahajan5 , Anindya Chowdhury1
1- Department of Medicine, MGM Medical College, Jamshedpur, India
2- Department of General Medicine, Rajendra Institute of Medical Sciences, Ranchi, India
3- Department of Lab Medicine, Delhi State Cancer Institute, Delhi, India ,kavyavarshney10@gmail.com
4- Department of Paediatrics, Lala Lajpat Rai Memorial Medical College, Meerut, India
5- Department of Medicine, Shaheed Nirmal Mahato Medical College and Hospital, Dhanbad, India
2- Department of General Medicine, Rajendra Institute of Medical Sciences, Ranchi, India
3- Department of Lab Medicine, Delhi State Cancer Institute, Delhi, India ,
4- Department of Paediatrics, Lala Lajpat Rai Memorial Medical College, Meerut, India
5- Department of Medicine, Shaheed Nirmal Mahato Medical College and Hospital, Dhanbad, India
Abstract: (419 Views)
Background: Stroke is one of the major causes of morbidity and mortality worldwide. Various studies have examined the neuroprotective effects of magnesium and potassium ions through their effects on the glutamate receptor and the endothelium, achieved by lowering blood pressure and through their anti-inflammatory and anti-apoptotic properties. The objective of our study was to determine the prognostic significance of serum magnesium and serum potassium levels in acute stroke.
Methods: An observational study was conducted at Rajendra Institute of Medical Sciences, Ranchi, for 18 months on 150 adults in patients with acute stroke, enrolled within 72 hours after applying appropriate inclusion and exclusion criteria. Correlations between the Modified Rankin Scale (mRS) score at discharge and the Glasgow Coma Scale (GCS) score at admission with serum levels of magnesium and potassium were calculated. Statistical analysis was performed using SPSS software version 27.0.
Results: Two groups were formed based on serum magnesium levels: <1.5 mg/dL and >1.5 mg/dL. Similarly, two groups were created based on serum potassium levels: <3.5 mEq/L and >3.5 mEq/L. A significant correlation was found, using Spearman’s coefficient test, between serum potassium and magnesium levels and the GCS score at admission, as well as the mRS score at discharge (p < 0.05).
Conclusion: Lower concentrations of magnesium and potassium are associated with increased cerebral arterial contraction and greater neurological damage.
Methods: An observational study was conducted at Rajendra Institute of Medical Sciences, Ranchi, for 18 months on 150 adults in patients with acute stroke, enrolled within 72 hours after applying appropriate inclusion and exclusion criteria. Correlations between the Modified Rankin Scale (mRS) score at discharge and the Glasgow Coma Scale (GCS) score at admission with serum levels of magnesium and potassium were calculated. Statistical analysis was performed using SPSS software version 27.0.
Results: Two groups were formed based on serum magnesium levels: <1.5 mg/dL and >1.5 mg/dL. Similarly, two groups were created based on serum potassium levels: <3.5 mEq/L and >3.5 mEq/L. A significant correlation was found, using Spearman’s coefficient test, between serum potassium and magnesium levels and the GCS score at admission, as well as the mRS score at discharge (p < 0.05).
Conclusion: Lower concentrations of magnesium and potassium are associated with increased cerebral arterial contraction and greater neurological damage.
Research Article: Research Article |
Subject:
Laboratory Sciences
Received: 2023/11/26 | Accepted: 2024/08/28 | Published: 2025/03/11 | ePublished: 2025/03/11
Received: 2023/11/26 | Accepted: 2024/08/28 | Published: 2025/03/11 | ePublished: 2025/03/11
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