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1- department of physical education and sports sciences central tehran branch, Islamic Azad University, Tehran, Iran
2- department of physical education and sports sciences central tehran branch, Islamic Azad University, Tehran, Iran ,amir.hajighasem01@gmail.com
3- department of physical education, Pardis Branch, Islamic Azad University, pardis, Iran
4- department of physical education and sports sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran
2- department of physical education and sports sciences central tehran branch, Islamic Azad University, Tehran, Iran ,
3- department of physical education, Pardis Branch, Islamic Azad University, pardis, Iran
4- department of physical education and sports sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran
Abstract: (244 Views)
Background and objectives: Non-alcoholic fatty liver disease (NAFLD), a highly prevalent and chronic liver disease, is characterized by a diverse range of conditions that span across a broad spectrum. Engaging in consistent physical activity has proven to be a successful method in effectively managing NAFLD, as it has demonstrated the ability to enhance crucial elements implicated in the development of the condition
Methods: Twenty-one male Wistar rats were divided into three groups: 1) NAFLD, 2) NAFLD + resistance training (RT), 3) NAFLD + RT + atorvastatin (ATO). The groups received high fat/fructose diet (HFFD) to induce NAFLD and it was confirmed through evaluation of histopathological analysis (H&E staining) and measurement of aminotransferase enzymes. ATO was administrated at the dose of 2 mg/kg/day. The interventions were done for eight weeks.
Results: Triglyceride (TG), Alanine transaminase (ALT), and aspartate transaminase (AST) were significantly reduced in the NAFLD + RT + ATO. Also, low-density lipoprotein (LDL) had lower level in NAFLD + RT in compared to NAFLD + RT + ATO. Alkaline phosphatase (ALP) was reduced in both NAFLD + RT and NAFLD + RT + ATO groups compared to NAFLD. There was no significant difference in weight between the groups except first, second, and forth week.
Conclusion: RT in combination with the administration of ATO can be deemed as an efficacious and supplementary strategy for the purpose of effectively controlling and addressing NAFLD.
Methods: Twenty-one male Wistar rats were divided into three groups: 1) NAFLD, 2) NAFLD + resistance training (RT), 3) NAFLD + RT + atorvastatin (ATO). The groups received high fat/fructose diet (HFFD) to induce NAFLD and it was confirmed through evaluation of histopathological analysis (H&E staining) and measurement of aminotransferase enzymes. ATO was administrated at the dose of 2 mg/kg/day. The interventions were done for eight weeks.
Results: Triglyceride (TG), Alanine transaminase (ALT), and aspartate transaminase (AST) were significantly reduced in the NAFLD + RT + ATO. Also, low-density lipoprotein (LDL) had lower level in NAFLD + RT in compared to NAFLD + RT + ATO. Alkaline phosphatase (ALP) was reduced in both NAFLD + RT and NAFLD + RT + ATO groups compared to NAFLD. There was no significant difference in weight between the groups except first, second, and forth week.
Conclusion: RT in combination with the administration of ATO can be deemed as an efficacious and supplementary strategy for the purpose of effectively controlling and addressing NAFLD.
Research Article: Research Article |
Subject:
Sport Physiology
Received: 2023/10/8 | Accepted: 2024/01/8
Received: 2023/10/8 | Accepted: 2024/01/8
References
1. Benedict M, Zhang X. Non-alcoholic fatty liver disease: An expanded review. World J Hepatol. 2017;9(16):715-32. [View at Publisher] [DOI] [PMID] [Google Scholar]
2. Zelber-Sagi S, Buch A, Yeshua H, Vaisman N, Webb M, Harari G, et al. Effect of resistance training on non-alcoholic fatty-liver disease a randomized-clinical trial. World J Gastroenterol. 2014;20(15):4382-92. [View at Publisher] [DOI] [PMID] [Google Scholar]
3. Hallsworth K, Fattakhova G, Hollingsworth KG, Thoma C, Moore S, Taylor R, et al. Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss. Gut. 2011;60(9):1278-83. [View at Publisher] [DOI] [PMID] [Google Scholar]
4. Westcott WL. Resistance training is medicine: effects of strength training on health. Curr Sports Med Rep. 2012;11(4):209-16. [View at Publisher] [DOI] [PMID] [Google Scholar]
5. van der Windt DJ, Sud V, Zhang H, Tsung A, Huang H. The Effects of Physical Exercise on Fatty Liver Disease. Gene Expr. 2018;18(2):89-101. [View at Publisher] [DOI] [PMID] [Google Scholar]
6. Dongiovanni P, Fracanzani AL, Fargion S, Valenti L. Iron in fatty liver and in the metabolic syndrome: A promising therapeutic target. J Hepatol. 2011;55(4):920-32. [View at Publisher] [DOI] [PMID] [Google Scholar]
7. Eslami Z, Moghanlou AE, Kandi Y, Arabi MS, Norouzi A, Joshaghani H. Atorvastatin and Flaxseed Effects on Biochemical Indices and Hepatic Fat of NAFLD Model in Rats. Adv Biomed Res. 2023;12:98. [View at Publisher] [DOI] [PMID] [Google Scholar]
8. Tan Q, Yu D, Song L. Atorvastatin disrupts primary human brain microvascular endothelial cell functions via prenylation-dependent mitochondrial inhibition and oxidative stress. Fundam Clin Pharmacol. 2021;35(2):341-50. [View at Publisher] [DOI] [PMID] [Google Scholar]
9. Kimura Y, Hyogo H, Yamagishi S, Takeuchi M, Ishitobi T, Nabeshima Y, et al. Atorvastatin decreases serum levels of advanced glycation endproducts (AGEs) in nonalcoholic steatohepatitis (NASH) patients with dyslipidemia: clinical usefulness of AGEs as a biomarker for the attenuation of NASH. J Gastroenterol. 2010;45(7):750-7. [View at Publisher] [DOI] [PMID] [Google Scholar]
10. Athyros VG, Tziomalos K, Gossios TD, Griva T, Anagnostis P, Kargiotis K, et al. Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis. Lancet. 2010;376(9756):1916-22. [View at Publisher] [DOI] [PMID] [Google Scholar]
11. Eslami Z, Mirghani SJ, Eghbal Moghanlou A, Norouzi A, Naseh H, Joshaghani H, et al. An Efficient Model of Non-alcoholic Fatty Liver Disease (NAFLD) Versus Current Experimental Models: Effects of Fructose, Fat, and Carbon Tetrachloride on NAFLD. Hepat Mon. 2021;21(8):e117696. [View at Publisher] [DOI] [Google Scholar]
12. Marumo H, Satoh K, Yamamoto A, Kaneta S, Ichihara K. Simvastatin and atorvastatin enhance hypotensive effect of diltiazem in rats. Yakugaku Zasshi. 2001;121(10):761-4. [View at Publisher] [DOI] [PMID] [Google Scholar]
13. Eslami Z, Mohammadnajad Panah kandi Y, Norouzi A, Eghbal Moghanlou A, Sheikh arabi M, Kazeminejad V, et al. Changes in Blood Lipids and Enzymatic Reactions in Response to Atorvastatin Administration Following a High-Fat Diet in a NAFLD Rat Model. MLJ. 2022;16(3):7-13. [View at Publisher] [DOI] [Google Scholar]
14. de Deus AP, de Oliveira CR, Simões RP, Baldissera V, da Silva CA, Rossi BRO, et al. Metabolic and Cardiac Autonomic Effects of High-Intensity Resistance Training Protocol in Wistar Rats. J Strength Cond Res. 2012;26(3):618-24. [View at Publisher] [DOI] [PMID] [Google Scholar]
15. Hashida R, Kawaguchi T, Bekki M, Omoto M, Matsuse H, Nago T, et al. Aerobic vs. resistance exercise in non-alcoholic fatty liver disease: A systematic review. J Hepatol. 2017;66(1):142-52. [View at Publisher] [DOI] [PMID] [Google Scholar]
16. Oh S, So R, Shida T, Matsuo T, Kim B, Akiyama K, et al. High-Intensity Aerobic Exercise Improves Both Hepatic Fat Content and Stiffness in Sedentary Obese Men with Nonalcoholic Fatty Liver Disease. Sci Rep. 2017;7:43029. [View at Publisher] [DOI] [PMID] [Google Scholar]
17. Jia GY, Han T, Gao L, Wang L, Wang SC, Yang L, et al. [Effect of aerobic exercise and resistance exercise in improving non-alcoholic fatty liver disease: a randomized controlled trial]. Zhonghua Gan Zang Bing Za Zhi. 2018;26(1):34-41. [View at Publisher] [DOI] [PMID] [Google Scholar]
18. Pekkala S, Rafiei MM, Eslami Z, Ghaderi M, Moghanlou AE, Sharifian S, et al. High-intensity interval training and moderate intensity training with exogenous adenosine counteract development of obesity in rats. Science & Sports. 2022;37(5):477-85. [View at Publisher] [DOI] [Google Scholar]
19. Eslami Z, Mohammadnajad PanahKandi Y, Sharifian S, Eghbal Moghanlou A, Sheikh SR, Mirghani SJ. Evaluation of the effect of aerobic exercise on UCP1 and MAPK p38 heat factor gene expression in subcutaneous adipose tissue in male Wistar rats fed a high-fat diet. Feyz Medical Sciences Journal. 2021;25(4):1020-30. [View at Publisher] [Google Scholar]
20. Eslami Z, Mohammad nezhad panah kandi Y, Ghaderi M, Eghbal Moghanlou A, Sharifian S, Beyshami G, et al. The effect of endurance training combined with adenosine on the gene expression of UCP-1 and MAPK p38 in subcutaneous adipose tissue of male Wistar rats fed a high -fat diet. Scientific Magazine Yafte. 2023;25(3):66-79. [View at Publisher] [DOI] [Google Scholar]
21. Mirghani SJ, Azarbayjani MA, Peeri M, , keshtkar A. Interaction Effect of Vitamin D Injection during a Course of Endurance Training on Anthropometrical Parameters with High-Fat Diet-Induced Obesity in Wistar Rats. MLJ. 2019;13(6):1-11. [View at Publisher] [DOI] [Google Scholar]
22. Mirghani SJ, Azarbayjani MA, Peeri M. Effects of Endurance Training and Isocaloric High Intensity Interval Training on Anthropometric Indices and Insulin Resistance in High Fat Diet-Fed Wistar Rats. MLJ . 2018;12(6):12. [View at Publisher] [DOI] [Google Scholar]
23. Rezende RE, Duarte SM, Stefano JT, Roschel H, Gualano B, de Sá Pinto AL, et al. Randomized clinical trial: benefits of aerobic physical activity for 24 weeks in postmenopausal women with nonalcoholic fatty liver disease. Menopause. 2016;23(8):876-83. [View at Publisher] [DOI] [PMID] [Google Scholar]
24. Charatcharoenwitthaya P, Kuljiratitikal K, Aksornchanya O, Chaiyasoot K, Bandidniyamanon W, Charatcharoenwitthaya N. Moderate-Intensity Aerobic vs Resistance Exercise and Dietary Modification in Patients With Nonalcoholic Fatty Liver Disease: A Randomized Clinical Trial. Clin Transl Gastroenterol. 2021;12(3):e00316. [View at Publisher] [DOI] [PMID] [Google Scholar]
25. Mirghani SJ, Agha-Alinejad H, Azarbayjani MA, Arshadi S, Mazidi A, Mirghani SA. Effect of 8 weeks concurrent training on blood lipid profile and body mass index in young men. International Medical Journal. 2012;19(3). [View at Publisher] [Google Scholar]
26. Mirghani SJ, Agha Alinejad H, Azarbayjani MA, Mazidi A, Mirghani SA. Influence of strength, endurance and concurrent training on the lipid profile and blood testosterone and cortisol response in young male wrestlers. Balt J Health Phys Act. 2014;6(1). [View at Publisher] [DOI] [Google Scholar]
27. Ji G, Zhao X, Leng L, Liu P, Jiang Z. Comparison of dietary control and atorvastatin on high fat diet induced hepatic steatosis and hyperlipidemia in rats. Lipids Health Dis. 2011;10:23. [View at Publisher] [DOI] [PMID] [Google Scholar]
28. Youssef MK, Philip MV. Resistance Training Versus Aerobic Training on Obese Non Alcoholic Fatty Liver. 2014. [View at Publisher] [Google Scholar]
29. Oh S, Shida T, Sawai A, Maruyama T, Eguchi K, Isobe T, et al. Acceleration training for managing nonalcoholic fatty liver disease: a pilot study. Ther Clin Risk Manag. 2014;10:925-36. [View at Publisher] [DOI] [PMID] [Google Scholar]
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