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mljgoums 2024, 18(2): 29-31 |
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Jalili Rasti S, Younessi Heravi M A, Yaghubi A, Cheragh Birjandi S. Investigating the changes of hippocampal m-RNA gene expression of neurotrophin-3
and its receptor (Tropomyosin Receptor Kinase C) in the recovery of movements of rats
with spinal cord injury during two types of endurance exercises. mljgoums 2024; 18 (2) :29-31
URL: http://mlj.goums.ac.ir/article-1-1693-en.html
URL: http://mlj.goums.ac.ir/article-1-1693-en.html
1- Department of Sport Science, Islamic Azad University, Bojnourd Branch, Bojnourd, Iran
2- Department of Medical Physics and Radiology, North Khorasan University of Medical Sciences, Bojnurd, Iran
3- Department of Sport Science, Islamic Azad University, Bojnourd Branch, Bojnourd, Iran ,S_birjandi2001@yahoo.com
2- Department of Medical Physics and Radiology, North Khorasan University of Medical Sciences, Bojnurd, Iran
3- Department of Sport Science, Islamic Azad University, Bojnourd Branch, Bojnourd, Iran ,
Abstract: (160 Views)
Background: This study aimed to investigate the effect of four weeks of selected endurance training on neurotrophin-3 (NT-3) and tropomyosin receptor kinase C (TrkC) gene expression in hippocampal areas of rats with spinal cord injury (SCI).
Methods: In this experimental study, the rats were separated into six equal groups. First, the animals were put under general anesthesia and had their SCI. Then, for four weeks, they were subjected to two kinds of endurance training programs. However, the control injury group received no intervention or training. Following the completion of the training regimes, molecular tests were done using the qRT-PCR technique to evaluate changes in the gene expression of NT-3 and TrkC from the animals' hippocampus.
Results: The expression of NT-3 and TrkC genes were significantly reduced in the SCI model compared to the healthy control group, but it was increased in the SCI + exercise 1 and SCI + exercise 2 groups compared to the SCI group. NT-3 levels did not vary significantly between the SCI + exercise 1 and SCI + exercise 2 groups, although alterations in TrkC levels altered.
Conclusion: In addition to enhancing locomotion in animals with SCI, the endurance training regimens in this research were effective on the expression of NT-3 and TrkC genes and may play a role in axonal development and neuronal survival in SCI recovery.
Methods: In this experimental study, the rats were separated into six equal groups. First, the animals were put under general anesthesia and had their SCI. Then, for four weeks, they were subjected to two kinds of endurance training programs. However, the control injury group received no intervention or training. Following the completion of the training regimes, molecular tests were done using the qRT-PCR technique to evaluate changes in the gene expression of NT-3 and TrkC from the animals' hippocampus.
Results: The expression of NT-3 and TrkC genes were significantly reduced in the SCI model compared to the healthy control group, but it was increased in the SCI + exercise 1 and SCI + exercise 2 groups compared to the SCI group. NT-3 levels did not vary significantly between the SCI + exercise 1 and SCI + exercise 2 groups, although alterations in TrkC levels altered.
Conclusion: In addition to enhancing locomotion in animals with SCI, the endurance training regimens in this research were effective on the expression of NT-3 and TrkC genes and may play a role in axonal development and neuronal survival in SCI recovery.
Research Article: Research Article |
Subject:
Sport Physiology
Received: 2023/07/15 | Accepted: 2023/10/9 | Published: 2024/03/27 | ePublished: 2024/03/27
Received: 2023/07/15 | Accepted: 2023/10/9 | Published: 2024/03/27 | ePublished: 2024/03/27
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