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mljgoums 2024, 18(3): 29-31 |
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Baniaghil S S, Balochi F, Ahmadi A. Evaluation prevalence of Rh system major antigens (D, C, c, E, e) and their phenotypes in blood donors of Golestan province, Iran. mljgoums 2024; 18 (3) :29-31
URL: http://mlj.goums.ac.ir/article-1-1595-en.html
URL: http://mlj.goums.ac.ir/article-1-1595-en.html
1- Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
2- Laboratory Science Research Center, Golestan University of Medical Sciences, Golestan, Iran ,drahmadi@goums.ac.ir
2- Laboratory Science Research Center, Golestan University of Medical Sciences, Golestan, Iran ,
Abstract: (833 Views)
Background: The understanding of blood group phenotypes is currently limited to the ABO and Rh blood group systems. This study aimed to determine the frequency of Rh system antigens (D, C, c, E, e) and the phenotypes of the system in blood donors. Identifying the blood group phenotypes of donors in any population is important for improving healthcare services and better serving patients.
Methods: This descriptive study was carried out on 575 donors (Turkmen and Fars) in blood transfusion centers in Golestan Province, Iran. A cell suspension (3-5%) from each sample was prepared in normal saline and exposed to Rh system antisera using the haemagglutination technique. The Rh phenotype was then determined based on the most common genotype.
Results: For the Rh system, the antigen frequencies of D, C, c, E, and e were 87.76%, 73.6%, 72.1%, 30.83%, and 93.59%, respectively. The most common phenotypes among the Turkmen and Fars donors were R1R1, R1r, and rr, respectively, while the least common phenotypes were R2Rz and ryry. The phenotypes r'r' and ryry were not detected in the Turkmen donors, and the phenotype r''r' was not identified in the Fars donors.
Conclusion: Identifying the prevalence of blood group antigens in donors from each region is crucial for organizing negative antigen blood units, preparing compatible blood for multitransfused patients, and preventing the development of alloantibodies in these patients.
Methods: This descriptive study was carried out on 575 donors (Turkmen and Fars) in blood transfusion centers in Golestan Province, Iran. A cell suspension (3-5%) from each sample was prepared in normal saline and exposed to Rh system antisera using the haemagglutination technique. The Rh phenotype was then determined based on the most common genotype.
Results: For the Rh system, the antigen frequencies of D, C, c, E, and e were 87.76%, 73.6%, 72.1%, 30.83%, and 93.59%, respectively. The most common phenotypes among the Turkmen and Fars donors were R1R1, R1r, and rr, respectively, while the least common phenotypes were R2Rz and ryry. The phenotypes r'r' and ryry were not detected in the Turkmen donors, and the phenotype r''r' was not identified in the Fars donors.
Conclusion: Identifying the prevalence of blood group antigens in donors from each region is crucial for organizing negative antigen blood units, preparing compatible blood for multitransfused patients, and preventing the development of alloantibodies in these patients.
Research Article: Research Article |
Subject:
Immunology
Received: 2022/11/12 | Accepted: 2023/04/11 | Published: 2024/06/3 | ePublished: 2024/06/3
Received: 2022/11/12 | Accepted: 2023/04/11 | Published: 2024/06/3 | ePublished: 2024/06/3
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