Volume 17, Issue 2 (Mar-Apr 2023)                   mljgoums 2023, 17(2): 26-32 | Back to browse issues page

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rashidpour F, farzanegi P, abbaszadeh H. Evaluation of Cyclooxygenase-2 and Prostaglandin E2 Expression in Endometrial Tissue Following 8 Weeks of Swimming Exercise and Omega-3 Intake. mljgoums 2023; 17 (2) :26-32
URL: http://mlj.goums.ac.ir/article-1-1536-en.html
1- Department of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, Iran
2- Department of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, , parvin.farzanegi@gmil.com
Abstract:   (820 Views)
Background and objectives: Endometriosis is a chronic disease that affects approximately 10% of women of reproductive age. The purpose of this study was to evaluate the effects of 8 weeks of swimming exercise and omega-3 supplementation on the expression of cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) genes and serum levels of reproductive hormones in the endometrial tissue of a rat model of endometriosis.
Methods: In this experimental study, 30 adult Wistar rats were randomly divided into 5 groups of healthy-control, patient-control, patient+exercise, patient+omega-3, and patient+omega-3+exercise groups. After the induction of endometriosis, the rats were subjected to 8 weeks of swimming exercise, 5 days a week as well as 2 ml/kg/body weight of omega-3. Data were analyzed using one-way analysis of variance and Tukey post hoc test at the significance level of 0.05.
Results: The expression of COX-2 and PGE2 as well as serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estradiol levels were significantly higher in the patient group compared with the healthy-control group (p≤0.0001). Exercise and omega-3 supplementation either separately or combined could significantly reduce the expression of both genes and serum levels of LH, FSH, and estradiol (p<0.05). This effect was more profound in the patient+exercise+omega-3 group.
Conclusion: The results of the present study indicate that regulating the expression of COX-2 and PGE2 genes as well as serum levels of reproductive hormones through swimming exercise and omega-3 supplementation can improve endometriosis.
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Research Article: Research Article | Subject: Others
Received: 2022/06/19 | Accepted: 2022/08/31 | Published: 2023/03/14 | ePublished: 2023/03/14

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