Wed, Jan 15, 2025
Volume 17, Issue 3 (May-Jun 2023)
mljgoums 2023, 17(3): 22-31 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Firoozeh F, Firoozeh A, Salmani A. An Update on the Prevalence of Nontuberculous Mycobacteria in Clinical Samples in Iran during 2000-2022: A Systematic Review and Meta-Analysis. mljgoums 2023; 17 (3) :22-31
URL: http://mlj.goums.ac.ir/article-1-1491-en.html
URL: http://mlj.goums.ac.ir/article-1-1491-en.html
1- Department of Microbiology, Islamic Azad University of Damghan, Damghan, Iran
2- Mashhad Uni Meed Sci ,arez90fir89@yahoo.com
3- Gerash Uni Med Sci
2- Mashhad Uni Meed Sci ,
3- Gerash Uni Med Sci
Abstract: (2010 Views)
Background and objectives: Nontuberculous mycobacteria (NTM) are isolated from domestic and animal products as well as man-made systems such as medical devices, drinking water systems, water tanks, and shower streams. This study aimed to investigate the prevalence of NTM in clinical samples in Iran during 2000-2022.
Methods: Published studies addressing the prevalence of NTM in clinical samples in Iran were reviewed according to the Preferred Reporting Items for Meta-Analyses and Systematic Reviews protocol. Original articles in Persian and English published between January 2000 and 2022 in databases such as Scopus, PubMed, Web of Science, Google Scholar, and Iranian databases were included. The prevalence of NTM at 95% confidence interval (CI) was calculated by comprehensive meta-analysis.
Results: Overall, 26 studies were included in the review. The combined prevalence of NTM in positive mycobacterial cultures was 4.5% (95% Cl: 3.1-6.5). Mycobacterium simiae [35.8% (95% CI 16.4-44.4)], Mycobacterium intracellulare [19% (95% CI 8.7-28.3)], and Mycobacterium kansasii [13.4% (95% CI 7.3-24.3)] were the most common slowly growing species, while Mycobacterium fortuitum [24.6% (95% CI 12.9-46.7)], Mycobacterium terrae [18.5 % (95% CI 11.5-29.2)], and Mycobacterium gastri [15.9% (95% CI6.0-41.2)] were the most prevalent rapidly growing mycobacteria.
Methods: Published studies addressing the prevalence of NTM in clinical samples in Iran were reviewed according to the Preferred Reporting Items for Meta-Analyses and Systematic Reviews protocol. Original articles in Persian and English published between January 2000 and 2022 in databases such as Scopus, PubMed, Web of Science, Google Scholar, and Iranian databases were included. The prevalence of NTM at 95% confidence interval (CI) was calculated by comprehensive meta-analysis.
Results: Overall, 26 studies were included in the review. The combined prevalence of NTM in positive mycobacterial cultures was 4.5% (95% Cl: 3.1-6.5). Mycobacterium simiae [35.8% (95% CI 16.4-44.4)], Mycobacterium intracellulare [19% (95% CI 8.7-28.3)], and Mycobacterium kansasii [13.4% (95% CI 7.3-24.3)] were the most common slowly growing species, while Mycobacterium fortuitum [24.6% (95% CI 12.9-46.7)], Mycobacterium terrae [18.5 % (95% CI 11.5-29.2)], and Mycobacterium gastri [15.9% (95% CI6.0-41.2)] were the most prevalent rapidly growing mycobacteria.
Conclusion: In summary, our findings indicate a relatively high combined prevalence of NTM in clinical samples in Iran. Some of these species such as M. simiae can have clinical and radiologic manifestations similar to those of TB and are resistant to anti-TB drugs. Therefore, standardizing the use of molecular methods for the detection of NTM seems necessary.
Research Article: Systematic Review |
Subject:
Others
Received: 2022/03/2 | Accepted: 2022/06/6 | Published: 2023/05/21 | ePublished: 2023/05/21
Received: 2022/03/2 | Accepted: 2022/06/6 | Published: 2023/05/21 | ePublished: 2023/05/21
References
1. Raju RM, Raju SM, Zhao Y, Rubin EJ. Leveraging advances in tuberculosis diagnosis and treatment to address nontuberculous mycobacterial disease. Emerging infectious diseases. 2016; 22(3): 365. [View at Publisher] [DOI:10.3201/eid2203.151643] [PubMed] [Google Scholar]
2. Khaledi A, Bahador A, Esmaeili D, Ghazvini K. Prevalence of Nontuberculous Mycobacteria (NTM) in Iranian clinical specimens: systematic review and meta-analysis. Journal of Medical Bacteriology. 2016;5(3-4):29-40. [View at Publisher] [Google Scholar]
3. Falkinham 3rd J. Epidemiology of infection by nontuberculous mycobacteria. Clinical microbiology reviews. 1996;9(2):177-215. [DOI:10.1128/CMR.9.2.177] [PubMed] [Google Scholar]
4. Khaledi A, Bahador A, Esmaeili D, Tafazoli A, Ghazvini K, Mansury D. Prevalence of nontuberculous mycobacteria isolated from environmental samples in Iran: A meta-analysis. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences. 2016;21. [DOI:10.4103/1735-1995.187306] [PubMed] [Google Scholar]
5. Hagiwara E, Komatsu S, Nishihira R, Shinohara T, Baba T, Ogura T. Clinical characteristics and prevalence of pneumothorax in patients with pulmonary Mycobacterium avium complex disease. Journal of Infection and Chemotherapy. 2013; 19(4): 588-92. [View at Publisher] [DOI:10.1007/s10156-012-0518-0] [PubMed] [Google Scholar]
6. Hett EC, Rubin EJ. Bacterial growth and cell division: a mycobacterial perspective. Microbiology and Molecular Biology Reviews. 2008;72(1):126-56. [View at Publisher] [DOI:10.1128/MMBR.00028-07] [PubMed] [Google Scholar]
7. van Ingen J, Boeree MJ, van Soolingen D, Mouton JW. Resistance mechanisms and drug susceptibility testing of nontuberculous mycobacteria. Drug Resistance Updates. 2012; 15(3): 149-61. [View at Publisher] [DOI:10.1016/j.drup.2012.04.001] [PubMed] [Google Scholar]
8. Faria S, Joao I, Jordao L. General overview on nontuberculous mycobacteria, biofilms, and human infection. Journal of pathogens. 2015;2015:809014. [View at Publisher] [DOI:10.1155/2015/809014] [PubMed] [Google Scholar]
9. Gopinath K, Singh S. Non-tuberculous mycobacteria in TB-endemic countries: are we neglecting the danger? PLoS neglected tropical diseases. 2010;4(4):e615. [View at Publisher] [DOI:10.1371/journal.pntd.0000615] [PubMed] [Google Scholar]
10. Muyoyeta M, Schaap J, De Haas P, Mwanza W, Muvwimi M, Godfrey-Faussett P, et al. Comparison of four culture systems for Mycobacterium tuberculosis in the Zambian National Reference Laboratory. The international journal of tuberculosis and lung disease. 2009;13(4):460-5. [View at Publisher] [PubMed] [Google Scholar]
11. Aliyu G, El-Kamary SS, Abimiku Al, Brown C, Tracy K, Hungerford L, et al. Prevalence of non-tuberculous mycobacterial infections among tuberculosis suspects in Nigeria. PloS one. 2013;8(5):e63170. [View at Publisher] [DOI:10.1371/journal.pone.0063170] [PubMed] [Google Scholar]
12. Pokam BT, Asuquo AE. Acid-fast bacilli other than mycobacteria in tuberculosis patients receiving directly observed therapy short course in cross river state, Nigeria. Tuberculosis research and treatment. 2012;2012:301056. [View at Publisher] [DOI:10.1155/2012/301056] [PubMed] [Google Scholar]
13. Ernst P, Fitzgerald JM, Spier S. Canadian asthma consensus conference summary of recommendations. Canadian Respiratory Journal. 1996; 3(2): 89-101. [View at Publisher] [DOI:10.1155/1996/314657] [Google Scholar]
14. RUNYON EH. Anonymous mycobacteria in pulmonary disease. Med Clin North Am. 1959;43(1):273-90. [DOI:10.1016/S0025-7125(16)34193-1] [PubMed] [Google Scholar]
15. Jarzembowski JA, Young MB. Nontuberculous mycobacterial infections. Archives of pathology & laboratory medicine. 2008;132(8):1333-41. [View at Publisher] [DOI:10.5858/2008-132-1333-NMI] [PubMed] [Google Scholar]
16. Porvaznik I, Solovič I, Mokrý J. Non-tuberculous mycobacteria: classification, diagnostics, and therapy. Respiratory treatment and prevention. 2017; 944: 19-25. [View at Publisher] [DOI:10.1007/5584_2016_45] [PubMed] [Google Scholar]
17. Hanak V, Kalra S, Aksamit TR, Hartman TE, Tazelaar HD, Ryu JH. Hot tub lung: presenting features and clinical course of 21 patients. Respiratory medicine. 2006;100(4):610-5. [View at Publisher] [DOI:10.1016/j.rmed.2005.08.005] [PubMed] [Google Scholar]
18. Nasiri MJ, Dabiri H, Darban-Sarokhalil D, Hashemi Shahraki A. Prevalence of non-tuberculosis mycobacterial infections among tuberculosis suspects in Iran: systematic review and meta-analysis. PloS one. 2015;10(6):e0129073. [DOI:10.1371/journal.pone.0129073] [PubMed] [Google Scholar]
19. Programme CAS. 10 questions to help you make sense of qualitative research. Public Health Resource Unit England; 2006.
20. Hosseini M, Shakerimoghaddam A, Ghazalibina M, Khaledi A. Aspergillus coinfection among patients with pulmonary tuberculosis in Asia and Africa countries; a systematic review and meta-analysis of cross-sectional studies. Microbial pathogenesis. 2020;141:104018. [View at Publisher] [DOI:10.1016/j.micpath.2020.104018] [PubMed] [Google Scholar]
21. Velayati AA, Rahideh S, Nezhad ZD, Farnia P, Mirsaeidi M. Nontuberculous mycobacteria in Middle East: Current situation and future challenges. International journal of mycobacteriology. 2015;4(1):7-17. [View at Publisher] [DOI:10.1016/j.ijmyco.2014.12.005] [PubMed] [Google Scholar]
22. Velayati AA, Farnia P, Mozafari M, Mirsaeidi M. Nontuberculous mycobacteria isolation from clinical and environmental samples in Iran: twenty years of surveillance. BioMed research international. 2015;2015:254285. [View at Publisher] [DOI:10.1155/2015/254285] [PubMed] [Google Scholar]
23. Varghese B, Memish Z, Abuljadayel N, Al-Hakeem R, Alrabiah F, Al-Hajoj SA. Emergence of clinically relevant non-tuberculous mycobacterial infections in Saudi Arabia. PLoS neglected tropical diseases. 2013; 7(5): e2234. [View at Publisher] [DOI:10.1371/journal.pntd.0002234] [PubMed] [Google Scholar]
24. Maiga M, Siddiqui S, Diallo S, Diarra B, Traoré B, Shea YR, et al. Failure to recognize nontuberculous mycobacteria leads to misdiagnosis of chronic pulmonary tuberculosis. PloS one. 2012;7(5):e36902. [View at Publisher] [DOI:10.1371/journal.pone.0036902] [PubMed] [Google Scholar]
25. Shahraki AH, Heidarieh P, Bostanabad SZ, Khosravi AD, Hashemzadeh M, Khandan S, et al. "Multidrug-resistant tuberculosis" may be nontuberculous mycobacteria. European journal of internal medicine. 2015;26(4):279-84. [View at Publisher] [DOI:10.1016/j.ejim.2015.03.001] [PubMed] [Google Scholar]
26. Van Ingen J, Bendien SA, De Lange WC, Hoefsloot W, Dekhuijzen PR, Boeree MJ, et al. Clinical relevance of non-tuberculous mycobacteria isolated in the Nijmegen-Arnhem region, The Netherlands. Thorax. 2009;64(6):502-6. [DOI:10.1136/thx.2008.110957] [PubMed] [Google Scholar]
27. Marras TK, Daley CL. Epidemiology of human pulmonary infection with nontuberculous mycobacteria. Clinics in chest medicine. 2002;23(3):553-68. [DOI:10.1016/S0272-5231(02)00019-9] [PubMed] [Google Scholar]
28. Chu H, Zhao L, Xiao H, Zhang Z, Zhang J, Gui T, et al. Prevalence of nontuberculous mycobacteria in patients with bronchiectasis: a meta-analysis. Archives of medical science: AMS. 2014;10(4):661. [View at Publisher] [DOI:10.5114/aoms.2014.44857] [PubMed] [Google Scholar]
29. Hernández-Garduño E. Comment on "Nontuberculous Mycobacteria Isolation from Clinical and Environmental Samples in Iran: Twenty Years of Surveillance". BioMed research international. 2015;2015:327068. [View at Publisher] [DOI:10.1155/2015/327068] [PubMed] [Google Scholar]
30. De Groote MA, Huitt G. Infections due to rapidly growing mycobacteria. Clin Infect Dis. 2006; 42(12): 1756-63. [View at Publisher] [DOI:10.1086/504381] [PubMed]
31. Carson LA, Petersen NJ, Favero MS, Aguero SM. Growth characteristics of atypical mycobacteria in water and their comparative resistance to disinfectants. Applied and Environmental Microbiology. 1978;36(6):839-46. [View at Publisher] [DOI:10.1128/aem.36.6.839-846.1978] [PubMed] [Google Scholar]
32. Mokaddas E, Ahmad S. Species spectrum of nontuberculous mycobacteria isolated from clinical specimens in Kuwait. Current microbiology. 2008; 56(5): 413-7. [View at Publisher] [DOI:10.1007/s00284-008-9102-3] [PubMed] [Google Scholar]
33. Simons S, Van Ingen J, Hsueh P-R, Van Hung N, Dekhuijzen PR, Boeree MJ, et al. Nontuberculous mycobacteria in respiratory tract infections, eastern Asia. Emerging infectious diseases. 2011;17(3):343. [DOI:10.3201/eid170310060] [PubMed] [Google Scholar]
34. O'Brien RJ, Geiter LJ, Snider Jr DE. The epidemiology of nontuberculous mycobacterial diseases in the United States: results from a national survey. American Review of Respiratory Disease. 1987;135(5):1007-14. [DOI] [PubMed] [Google Scholar]
35. Cowman S, Burns K, Benson S, Wilson R, Loebinger M. The antimicrobial susceptibility of non-tuberculous mycobacteria. Journal of Infection. 2016;72(3):324-31. [View at Publisher] [DOI:10.1016/j.jinf.2015.12.007] [PubMed] [Google Scholar]
36. Baghaei P, Tabarsi P, Farnia P, Marjani M, Sheikholeslami FM, Chitsaz M, et al. Pulmonary disease caused by Mycobacterium simiae in Iran's national referral center for tuberculosis. The Journal of Infection in Developing Countries. 2012;6(01):23-8. [View at Publisher] [DOI:10.3855/jidc.1297] [PubMed] [Google Scholar]
37. Tabarsi P, Baghaei P, Farnia P, Mansouri N, Chitsaz E, Sheikholeslam F, et al. Nontuberculous mycobacteria among patients who are suspected for multidrug-resistant tuberculosis-need for earlier identification of nontuberculosis mycobacteria. The American journal of the medical sciences. 2009;337(3):182-4. [View at Publisher] [DOI:10.1097/MAJ.0b013e318185d32f] [PubMed] [Google Scholar]
38. Dvorska L, Bartos M, Martin G, Erler W, Pavlik I. Strategies for differentiation, identification and typing of medically important species of mycobacteria by molecular methods. VETERINARNI MEDICINA-PRAHA-. 2001;46(11/12):309-28. [View at Publisher] [DOI:10.17221/7890-VETMED] [Google Scholar]
39. Bahador A, Esmaeili D, Khaledi A, Ghorbanzadeh R. An in vitro assessment of the antibacterial properties of nanosilver Iranian MTA against Porphyromonas gingivalis. Journal of Chemical and Pharmaceutical Research. 2013;5(10):65-71. [View at Publisher] [Google Scholar]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Enamad
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.