Volume 16, Issue 4 (Jul-Aug 2022)                   mljgoums 2022, 16(4): 15-19 | Back to browse issues page

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Valipoor N, Namroodi S, Taziki S, Rezaei H. Effects of Bacterial Cellulose Nanofiber on Lead Concentration in Kidney and Liver Tissues of Wistar Rats. mljgoums. 2022; 16 (4) :15-19
URL: http://mlj.goums.ac.ir/article-1-1446-en.html
1- Department of Environmental Sciences, Faculty of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Iran.
2- Department of Environmental Sciences, Faculty of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran , namroodi@gau.ac.ir
3- Ischemic Disorders Research Center ٫ Golestan University of Medical Sciences, Gorgan, Iran
4- Department of Environmental Sciences, Faculty of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran.
Abstract:   (133 Views)
Background and objectives: Lead (Pb) is among the most toxic pollutants that affect health of both humans and animals. Finding a way to prevent Pb accumulation in animals’ bodies seems necessary. Bacterial cellulose nanofiber (BCNF) can remove heavy metals from aqueous solutions. This study investigates effects of oral consumption of BCNF, as a chelator, on Pb concentration in the kidney and liver tissues of rats.
Methods: Sixteen Wistar rats (aged 6-8 weeks) were divided into four groups: 1. control, 2. fed with Pb, 3. fed with Pb (50 μg/g) and BCNF (16 μg/g) simultaneously, and 4. fed with Pb and BCNF with 4 hours interval. The rats were euthanized, and the kidney and liver tissues were separated. After acidic digestion of the tissue samples, Pb concentration was measured by atomic absorption spectrometry.
Results: The mean concentration of Pb in the kidney and liver tissues of rats fed with Pb and BCNF were significantly lower than that of rats fed only with Pb. In addition, the mean Pb concentration in rats of group 3 was lower than that of group 4.
Conclusion: The results of this study showed the favorable effects of BCNF on prevention of Pb accumulation in the kidney and liver tissues of rats. Moreover, removal of Pb may be related to binding of BCNF with Pb in the gut or blood. More studies are necessary to determine the exact mechanisms through which BCNF can reduce Pb accumulation.
 
Keywords: Rats, Wistar [MeSH], Lead [MeSH], Tissue [MeSH],
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Research Article: Original Paper | Subject: Others
Received: 2021/10/16 | Accepted: 2021/12/11 | Published: 2022/07/16 | ePublished: 2022/07/16

References
1. Natasha N, Dumat C, Shahid M, Khalid S, and Murtaza B. Lead pollution and human exposure: forewarned is forearmed, and the question now becomes how to respond to the threat! In Lead in Plants and the Environment. Springer. 2020; 33-65. [View at Publisher] [DOI:10.1007/978-3-030-21638-2_3] [Google Scholar]
2. ASTR.2005. Agency for toxic substances and disease registery toxicological profile for lead. U.S Department of health and human services. [View at Publisher]
3. Levin R, Zilli Vieira CL, Rosenbaum MH, Bischoff K, Mordarski DC, Brown MJ. The urban lead (Pb) burden in humans, animals and the natural environment. Environ Res. 2021; 193: 110377. [View at Publisher] [DOI:10.1016/j.envres.2020.110377] [PubMed] [Google Scholar]
4. Abdul Khalil HP, Davoudpour Y, Islam MN, Mustapha A, Sudesh K, Dungani R, Jawaid M. Production and modification of nanofibrillated cellulose using various mechanical processes: a review. Carbohydr Polym. 2014; 99: 649-65. [View at Publisher] [DOI:10.1016/j.carbpol.2013.08.069] [PubMed] [Google Scholar]
5. Azad Tirgan M. Protective effect of pomegranate extract against experimental lead poisoning in rats. PhD thesis. Ferdowsi University of Mashhad, Faculty of Veterinary Medicine. 2012.
6. Carpenter AW, de Lannoy CF, Wiesner MR. Cellulose nanomaterials in water treatment technologies. Environmental science & technology. 2015; 49(9): 5277-5287. [View at Publisher] [DOI:10.1021/es506351r] [PubMed] [Google Scholar]
7. D'souza HS, Dsouza SA, Menezes G, Venkatesh T. Diagnosis, evaluation, and treatment of lead poisoning in general population. Indian Journal of Clinical Biochemistry. 2011; 26(2): 197-201. [View at Publisher] [DOI:10.1007/s12291-011-0122-6] [PubMed] [Google Scholar]
8. Flora SJ, and Pachauri V. Chelation in metal intoxication. International journal of environmental research and public health. 2010; 7(7): 2745-2788. [View at Publisher] [DOI:10.3390/ijerph7072745] [PubMed] [Google Scholar]
9. Habibi Y, Lucia LA, Rojas OJ. Cellulose nanocrystals: chemistry, self-assembly, and applications. Chem Rev. 2010; 110(6): 3479-500. [View at Publisher] [DOI:10.1021/cr900339w] [PubMed] [Google Scholar]
10. Johari H. The Effect of Garlic (Allium Sativum) Extract on Lead Detoxification in Kidney Tissue of Neonatal Rat. Journal of Kerman University of Medical Sciences. 2012; 19(1): 31-39. [Persian] [View at Publisher]
11. Kardam A, Raj K.R, Srivastava S, and Srivastava MM. Nanocellulose fibers for biosorption of cadmium, nickel, and lead ions from aqueous solution. Clean Technologies and Environmental Policy. 2014; 16(2): 385-393. [View at Publisher] [DOI:10.1007/s10098-013-0634-2] [Google Scholar]
12. Kalia S, Dufresne A, Cherian B.M, Kaith B, Avérous L, and Njuguna J. Cellulose-based bio-and nanocomposites: a review. International Journal of Polymer Science. 2011; 20(2): 43-56. [View at Publisher] [DOI:10.1155/2011/837875] [Google Scholar]
13. Khazaeipour A, Namroodi S, and Taziki Sh. Effect of nanochitin on tissue absorption rate of lead acetate in rat liver. Journal of Gorgan University of Medical Sciences. 2020; 22(2): 34-39. [View at Publisher] [Google Scholar]
14. Klaassen C D. (Ed). Casarett and Doull's toxicology: the basic science of poisons (1236: 189). 2013; New York: McGraw-Hill. [View at Publisher] [Google Scholar]
15. Klemm D, Schumann D, Udhardt U, and Marsch S. Bacterial synthesized cellulose- artificial blood vessels for microsurgery. Progress in Polymer Sciences. 2001; 26(9):1561-603. [View at Publisher] [DOI:10.1016/S0079-6700(01)00021-1] [Google Scholar]
16. Ma H, Hsiao B.S, Chu B. Ultrafine cellulose nanofibers as efficient adsorbents for removal of UO22+ in water. ACS Macro Letters. 2011; 1(1):213-216. [View at Publisher] [DOI:10.1021/mz200047q] [PubMed] [Google Scholar]
17. Mehri A, Qasemian A. Maple A. Jafari R. Types of nanocellulose and its applications. Second National Conference on Sustainable Development of Agriculture and Healthy Environment. Hamedan. 2014. [View at Publisher]
18. Marianti A, Anatiasara D, and Ashar FF. Chitosan as chelating and protective agents from lead intoxication in rat. Biosaintifika: Journal of Biology & Biology Education. 2017; 9(1): 126-133. [View at Publisher] [DOI:10.15294/biosaintifika.v9i1.8943] [Google Scholar]
19. Abdel Moneim AE, Dkhil MA, Al-Quraishy S. The protective effect of flaxseed oil on lead acetate-induced renal toxicity in rats. J Hazard Mater. 2011; 194: 250-5. [View at Publisher] [DOI:10.1016/j.jhazmat.2011.07.097] [PubMed] [Google Scholar]
20. Rezaei H, Maghsoodlu S. Removal of Lead ions from Aqueous Solutions Using Bacterial Cellulose Nano Fibers Gel. Journal of Wood and Forest Science and Technology. 2017; 24(3): 197-208. [Persian] [View at Publisher] [Google Scholar]
21. Pal M, Sachdeva M, Gupta N, Mishra P, Yadav M, Tiwari A. Lead Exposure in Different Organs of Mammals and Prevention by Curcumin-Nanocurcumin: a Review. Biol Trace Elem Res. 2015; 168(2): 380-91. [View at Publisher] [DOI:10.1007/s12011-015-0366-8] [PubMed] [Google Scholar]
22. Rastgar S, Rezaei H, Yousefi H. Evaluation off lignocellulose nano-fiiber absorbent efficacy in lead removal from aqueous solutions. Iranian Journal of Wood and Paper Industries. 2018; 9 (2): 251-262. [View at Publisher] [Google Scholar]

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