Volume 18, Issue 1 (Jan-Feb 2024)                   mljgoums 2024, 18(1): 12-15 | Back to browse issues page


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Shirkhani S, barari A, Abbasi Daloii A, saravi M. Evaluating the expression of NOs and NOX2 genes in patients with coronary artery occlusion following aerobic exercise and Omega-3 intake. mljgoums 2024; 18 (1) :12-15
URL: http://mlj.goums.ac.ir/article-1-1332-en.html
1- Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran
2- Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran , alireza54.barari@gmail.com
3- Department of Cardiology, Babol University of Medical Sciences, Babol, Iran
Abstract:   (263 Views)
Background: Cardiovascular diseases, especially coronary artery problems, are the main causes of death. The aim of this study was to evaluate the expression of NOs and NOX2 in coronary artery patients after aerobic exercise and omega-3 intake.
Methods: The present study was a quasi-experimental study in which 32 men with coronary artery disease in the age range of 55 to 65 years were selected and randomly divided into 4 groups: control, exercise, omega-3, and omega-3 + exercise. The training program consisted of 8 weeks of intermittent running training, 3 sessions per week, with an intensity of 55 to 65% of the subjects' heart rate reserve and with an emphasis on gradual overload. Subjects consumed 1000 mg of omega-3 daily.
Results: There was a significant increase (P <0.0001) in the mean expression of the NOS gene in the exercise + omega-3 group compared to the control group. The mean ratio of NOX gene expression changes in the exercise group, omega-3, and the combination of exercise + omega-3 was significantly reduced compared to the control group (P <0.0001).
Conclusion: According to the results of the present study, the ability of exercise and omega-3 supplementation to reduce the level of oxidant stress and increase homeostasis control in coronary artery insufficiency shows an important molecular mechanism that underlies the benefits of these interventions.
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Research Article: Original Paper | Subject: Sport Physiology
Received: 2020/09/21 | Accepted: 2020/11/16 | Published: 2024/01/21 | ePublished: 2024/01/21

References
1. Mehrabi A, Salesi M, Pasavand P. Comparison of the effect of the exercise time (morning or evening) and the amount of Troponin T in men with cardiovascular diseases. Razi J Med Sci (RJMS). 2015;22(134):107-14. [View at Publisher] [Google Scholar]
2. Naghibi S, Maleki J. The effect of exercise training on anaerobic threshold and exercise tolerance in patients with coronary artery disease-medical social. Social Research. 2011;4(11):17-33. [View at Publisher] [Google Scholar]
3. Farahati S, Atarzadeh Hosseini SR, Bijeh N, Mahjoob O. The effect of aerobic exercising on plasma nitric oxide level and vessel endothelium function in postmenopausal women. Razi J Med Sci (RJMS). 2014;20(115):78-88. [View at Publisher] [Google Scholar]
4. Toprak I, Kucukatay V, Yildirim C, Kilic-Toprak E, Kilic-Erkek O. Increased systemic oxidative stress in patients with keratoconus. Eye (Lond). 2014;28(3):285-9. [View at Publisher] [DOI] [PMID] [Google Scholar]
5. Chan TO, Rittenhouse SE, Tsichlis PN. AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation. Annu Rev Biochem. 1999;68:965-1014. [View at Publisher] [DOI] [PMID] [Google Scholar]
6. Panth N, Paudel KR, Parajuli K. Reactive Oxygen Species: A Key Hallmark of Cardiovascular Disease. Adv Med. 2016;2016:9152732. [View at Publisher] [DOI] [PMID] [Google Scholar]
7. Spruit MA, Gosselink R, Troosters T, De Paepe K, Decramer M. Resistance versus endurance training in patients with COPD and peripheral muscle weakness. Eur Respir J. 2002;19(6):1072-8. [View at Publisher] [DOI] [PMID] [Google Scholar]
8. Fang J, Nakamura H, Maeda H. The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. Adv Drug Deliv Rev. 2011;63(3):136-51. [View at Publisher] [DOI] [PMID] [Google Scholar]
9. McLaughlin T, Reaven G, Abbasi F, Lamendola C, Saad M, Waters D, et al. Is there a simple way to identify insulin-resistant individuals at increased risk of cardiovascular disease? Am J Cardiol. 2005;96(3):399-404. [View at Publisher] [DOI] [PMID] [Google Scholar]
10. Adams V, Reich B, Uhlemann M, Niebauer J. Molecular effects of exercise training in patients with cardiovascular disease: focus on skeletal muscle, endothelium, and myocardium. Am J Physiol Heart Circ Physiol. 2017;313(1):H72-H88. [View at Publisher] [DOI] [PMID] [Google Scholar]
11. Mansouri S, Mokhtari-Hesari P, Naghavi-Al-Hosseini F, Majidzadeh AK, Farahmand L. The Prognostic Value of Circulating Tumor Cells in Primary Breast Cancer Prior to any Systematic Therapy: A Systematic Review. Curr Stem Cell Res Ther. 2019;14(6):519-29. [View at Publisher] [DOI] [PMID] [Google Scholar]
12. Golbidi S, Li H, Laher I. Oxidative Stress: A Unifying Mechanism for Cell Damage Induced by Noise, (Water-Pipe) Smoking, and Emotional Stress-Therapeutic Strategies Targeting Redox Imbalance. Antioxid Redox Signal. 2018;28(9):741-59. [View at Publisher] [DOI] [PMID] [Google Scholar]
13. Zill OA, Banks KC, Fairclough SR, Mortimer SA, Vowles JV, Mokhtari R, et al. The Landscape of Actionable Genomic Alterations in Cell-Free Circulating Tumor DNA from 21,807 Advanced Cancer Patients. Clin Cancer Res. 2018;24(15):3528-38. [View at Publisher] [DOI] [PMID] [Google Scholar]
14. Ooi JY, Bernardo BC, McMullen JR. The therapeutic potential of miRNAs regulated in settings of physiological cardiac hypertrophy. Future Med Chem. 2014;6(2):205-22. [View at Publisher] [DOI] [PMID] [Google Scholar]
15. Melo SF, Fernandes T, Barauna VG, Matos KC, Santos AA, Tucci PJ, et al. Expression of MicroRNA-29 and Collagen in Cardiac Muscle after Swimming Training in Myocardial-Infarcted Rats. Cell Physiol Biochem. 2014;33(3):657-69. [View at Publisher] [DOI] [PMID] [Google Scholar]
16. Lee BA, Oh DJ. The effects of long-term aerobic exercise on cardiac structure, stroke volume of the left ventricle, and cardiac output. J Exerc Rehabil. 2016;12(1):37-41. [View at Publisher] [DOI] [PMID] [Google Scholar]
17. Iraz M, Erdogan H, Ozyurt B, Ozugurlu F. Omega-3 essential fatty acid supplementation and erythrocyte oxidant/antioxidant status in rats. Ann Clin Lab Sci. 2005;35(2):169-73. [View at Publisher] [Google Scholar]
18. Friedman A, Moe S. Review of the effects of omega-3 supplementation in dialysis patients. Clin J Am Soc Nephrol. 2006;1(2):182-92. [View at Publisher] [DOI] [PMID] [Google Scholar]
19. Shapiro H, Tehilla M, Attal-Singer J, Bruck R, Luzzatti R, Singer P. The therapeutic potential of long-chain omega-3 fatty acids in nonalcoholic fatty liver disease. Clin Nutr. 2011;30(1):6-19. [View at Publisher] [DOI] [PMID] [Google Scholar]
20. Maki KC, Dicklin MR. Omega-3 Fatty Acid Supplementation and Cardiovascular Disease Risk: Glass Half Full or Time to Nail the Coffin Shut? Nutrients. 2018;10(7). [View at Publisher] [DOI] [PMID] [Google Scholar]
21. Mozaffarian D, Wu JH. Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events. J Am Coll Cardiol. 2011;58(20):2047-67. [View at Publisher] [DOI] [PMID] [Google Scholar]
22. Maki KC, Palacios OM, Bell M, Toth PP. Use of supplemental long-chain omega-3 fatty acids and risk for cardiac death: An updated meta-analysis and review of research gaps. J Clin Lipidol. 2017;11(5):1152-60. [View at Publisher] [DOI] [PMID] [Google Scholar]
23. Aung T, Halsey J, Kromhout D, Gerstein HC, Marchioli R, Tavazzi L, et al. Associations of Omega-3 Fatty Acid Supplement Use With Cardiovascular Disease Risks: Meta-analysis of 10 Trials Involving 77917 Individuals. JAMA Cardiol. 2018;3(3):225-33. [View at Publisher] [DOI] [PMID] [Google Scholar]
24. Meza CA, La Favor JD, Kim DH, Hickner RC. Endothelial Dysfunction: Is There a Hyperglycemia-Induced Imbalance of NOX and NOS? Int J Mol Sci. 2019;20(15). [View at Publisher] [DOI] [PMID] [Google Scholar]
25. Poudyal H, Panchal SK, Diwan V, Brown L. Omega-3 fatty acids and metabolic syndrome: effects and emerging mechanisms of action. Prog Lipid Res. 2011;50(4):372-87. [View at Publisher] [DOI] [PMID] [Google Scholar]
26. Joseph LC, Barca E, Subramanyam P, Komrowski M, Pajvani U, Colecraft HM, et al. Inhibition of NAPDH Oxidase 2 (NOX2) Prevents Oxidative Stress and Mitochondrial Abnormalities Caused by Saturated Fat in Cardiomyocytes. PLoS One. 2016;11(1):e0145750. [View at Publisher] [DOI] [PMID] [Google Scholar]
27. Adkins Y, Kelley DS. Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids. J Nutr Biochem. 2010;21(9):781-92. [View at Publisher] [DOI] [PMID] [Google Scholar]
28. Campos JC, Gomes KM, Ferreira JC. Impact of exercise training on redox signaling in cardiovascular diseases. Food Chem Toxicol. 2013;62:107-19. [View at Publisher] [DOI] [PMID] [Google Scholar]
29. Guzel NA, Pinar L, Colakoglu F, Karacan S, Ozer C. "Long-term callisthenic exercise-related changes in blood lipids, homocysteine, nitric oxide levels and body composition in middle-aged healthy sedentary women". Chin J Physiol. 2012;55(3):202-9. [View at Publisher] [DOI] [PMID] [Google Scholar]
30. Ghanimati R, Rajabi H, Ramezani F, Ramez M, Bapiran M, Nasirinezhad F. The effect of preconditioning with high-intensity training on tissue levels of G-CSF, its receptor and C-kit after an acute myocardial infarction in male rats. BMC Cardiovasc Disord. 2020;20(1):75. [View at Publisher] [DOI] [PMID] [Google Scholar]
31. McDonagh B, Sakellariou GK, Jackson MJ. Application of redox proteomics to skeletal muscle aging and exercise. Biochem Soc Trans. 2014;42(4):965-70. [View at Publisher] [DOI] [PMID] [Google Scholar]
32. Kian A, Gohari M. Designing and manufacturing a force plate specified for observing balance disabilities. Eur J Exp Biol. 2013;3(4),216-22. [View at Publisher] [Google Scholar]
33. Ren J, Yang L, Tian W, Zhu M, Liu J, Lu P, et al. Nitric oxide synthase inhibition abolishes exercise-mediated protection against isoproterenol-induced cardiac hypertrophy in female mice. Cardiology. 2015;130(3):175-84. [View at Publisher] [DOI] [PMID] [Google Scholar]
34. Alipour Y, Abbassi- Daloii A, Barari A, Abdi A. Effects of resistance training on serum levels of undercarboxylated osteocalcin, adiponectin and insulin sensitivity in obese women. Tehran University Medical Journal. 2015;73(9):668-73. [View at Publisher] [Google Scholar]

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