Sat, Apr 20, 2024
Volume 15, Issue 4 (Jul-Aug 2021)
mljgoums 2021, 15(4): 15-20 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Hamta A, Hosseinpour M, Komijani M. Association of Interleukin-16 Gene Polymorphisms rs11556218 T/G and rs4072111 C/T with Risk of Breast Cancer in an Iranian Population. mljgoums 2021; 15 (4) :15-20
URL: http://mlj.goums.ac.ir/article-1-1311-en.html
URL: http://mlj.goums.ac.ir/article-1-1311-en.html
1- Department of Biology, Faculty of Sciences, Arak University , a-hamta@araku.aC.IR
2- Department of Biology, Faculty of Sciences, Arak University
2- Department of Biology, Faculty of Sciences, Arak University
Abstract: (1682 Views)
Background and objectives: Breast cancer is the leading cause of death in women. Cytokines regulate the intensity and continuity of immune response by balancing cell-mediated immunity and humoral responses. This study aimed to investigate the relationship between two polymorphisms of the interleukin-16 (IL-16) gene and risk of breast cancer.
Methods: Blood samples were collected from 80 breast cancer patients and 80 healthy individuals. Polymorphisms rs11556218 T/G and rs4072111 C/T were investigated by polymerase chain reaction-restriction fragment length polymorphism (RFLP-PCR). Then, genotype and allele frequency distributions were evaluated in each group using the SPSS software (version 24).
Results: The frequency of genotype rs11556218 differed significantly between the patients and controls (P=0.007). The TG genotype (odds ratio [OR]= 2.471, 95% confidence intervals [CI]: 1.229-4.965, P= 0.001) and total TG+GG genotypes (OR= 3.095, 95% CI: 1.624-5.899, P= 0.001) had a significant relationship with increased risk for breast cancer. The allele and genotype frequencies of rs4072111 C/T polymorphism did not differ significantly between the patients and controls.
Conclusion: Our findings suggest that the rs11556218 T/G polymorphism of the IL-16 gene may be associated with susceptibility to breast cancer.
Research Article: Original Paper |
Subject:
Human Genetics
Received: 2020/08/17 | Accepted: 2021/03/1 | Published: 2021/06/30 | ePublished: 2021/06/30
Received: 2020/08/17 | Accepted: 2021/03/1 | Published: 2021/06/30 | ePublished: 2021/06/30
References
1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209-249. [View at Publisher] [DOI:10.3322/caac.21660] [PubMed] [Google Scholar]
2. Nguyen-Dien GT, Smith RA, Haupt LM, Griffiths LR, Nguyen HT. Genetic polymorphisms in miRNAs targeting the estrogen receptor and their effect on breast cancer risk. Meta gene. 2014; 2: 226-36. [View at Publisher] [DOI:10.1016/j.mgene.2014.01.002] [PubMed] [Google Scholar]
3. Rojas K, Stuckey A. Breast cancer epidemiology and risk factors. Clinical obstetrics and gynecology. 2016; 59(4): 651-72. [DOI:10.1097/GRF.0000000000000239] [PubMed] [Google Scholar]
4. Dieci MV, Griguolo G, Miglietta F, Guarneri V. The immune system and hormone-receptor-positive breast cancer: Is it really a dead end?. Cancer treatment reviews. 2016; 46: 9-19. [View at Publisher] [DOI:10.1016/j.ctrv.2016.03.011] [PubMed] [Google Scholar]
5. Jarczak J, Kaba J, Reczyńska D, Bagnicka E. Impaired expression of cytokines as a result of viral infections with an emphasis on small ruminant lentivirus infection in goats. Viruses. 2016; 8(7): 186. [DOI:10.3390/v8070186] [PubMed] [Google Scholar]
6. Richmond J, Tuzova M, Cruikshank W, Center D. Regulation of cellular processes by interleukin‐16 in homeostasis and cancer. Journal of Cellular Physiology. 2014; 229(2):139-47. [View at Publisher] [DOI:10.1002/jcp.24441] [PubMed] [Google Scholar]
7. Kwok PY. Single nucleotide polymorphisms: methods and protocols. Springer Science & Business Media; 2003. [View at Publisher] [DOI:10.1385/1592593275] [Google Scholar]
8. Bessenyei B, Marka M, Urban L, Zeher M, Semsei I. Single nucleotide polymorphisms: aging and diseases. Biogerontology. 2004; 5(5): 291-303. [DOI:10.1007/s10522-004-2567-y] [PubMed] [Google Scholar]
9. MaiMaiTiMin A, AHaTi Y, BaGeDaTi D, ABuDuReYiMu A. Genetic polymorphism of interleukin-16 rs11556218 T/G influences susceptibility to breast cancer in a Chinese population. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY. 2016; 9(3): 3931-6. [View at Publisher] [Google Scholar]
10. Shih LC, Chang WS, Lee HT, Wang YC, Wang ZH, Chao CY, et al. Interaction of interleukin-16 genotypes with betel quid chewing behavior on oral cancer in Taiwan. in vivo. 2020; 34(4): 1759-64. [View at Publisher] [DOI:10.21873/invivo.11969] [Google Scholar]
11. Wu MF, Wang YC, Shen TC, Chang WS, Li HT, Liao CH, et al. Significant Association of Interleukin-16 Genetic Variations to Taiwanese Lung Cancer. In Vivo. 2020; 34(3): 1117-23. [View at Publisher] [DOI:10.21873/invivo.11883] [PubMed] [Google Scholar]
12. Shan Li, Yan Deng, Zhi-Ping Chen, Shan Huang, Xiang-Cheng Liao, Li-Wen Lin, et al. Genetic polymorphism of interleukin-16 influences susceptibility to HBV-related hepatocellular carcinoma in a Chinese population. Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases. 2011; 11(8): 2083-8 [View at Publisher] [DOI:10.1016/j.meegid.2011.09.025] [PubMed] [Google Scholar]
13. Gao LB, Rao L, Wang YY, Liang WB, Li C, Xue H, et al. The association of interleukin-16 polymorphisms with IL-16 serum levels and risk of colorectal and gastric cancer. Carcinogenesis. 2009; 30(2): 295-9. [View at Publisher] [DOI:10.1093/carcin/bgn281] [PubMed] [Google Scholar]
14. Zhou T, Li H, Xie WJ, Zhong Z, Zhong H, Lin ZJ. Association of methylenetetrahydrofolate reductase, vitamin D receptor, and interleukin-16 gene polymorphisms with renal cell carcinoma risk. Technology in cancer research & treatment. 2019; 18: 1533033819859413. [DOI:10.1177/1533033819859413] [PubMed] [Google Scholar]
15. Kashfi SM, Farahbakhsh FB, Mojarad EN, Mashayekhi K, Azimzadeh P, Romani S, et al. Interleukin-16 polymorphisms as new promising biomarkers for risk of gastric cancer. Tumor Biology. 2016; 37(2): 2119-26. [DOI:10.1007/s13277-015-4013-y] [PubMed] [Google Scholar]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Enamad
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.