Volume 15, Issue 1 (Jan-Feb 2021)                   mljgoums 2021, 15(1): 8-12 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Karimi M, Moazzami M, Rezaeian N. Effects of Eight Weeks of Core Stability Training on Serum level of Progranulin and Tumor Necrosis Factor Alpha in Women with Multiple Sclerosis. mljgoums. 2021; 15 (1) :8-12
URL: http://mlj.goums.ac.ir/article-1-1310-en.html
1- Department of Exercise Physiology, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran
2- Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran , Moazami@um.ac.ir
3- Department of Exercise Physiology, Bojnourd Branch ,Islamic Azad University, Bojnourd, Iran
Abstract:   (855 Views)

Background and objectives: Multiple sclerosis (MS) is a common debilitating neurodegenerative disease caused by inflammatory demyelinating processes in the central nervous system. The present study aimed to evaluate the effects of core stability training on serum levels of progranulin and tumor necrosis factor alpha (TNF-α) in women with MS.

Methods: The study population consisted of 24 women with MS (aged 25 to 40 years) in Bojnourd (Iran) with expanded disability status scale score of 2-5. Patients were randomly divided into two groups of core stability training (n=12) and control (n=12). The training group performed 30-40 minutes of core stability training, three sessions a week for eight weeks. Blood sampling was done 24 hours before the first session and 48 hours after the last training session. Serum levels of progranulin and TNF-α were measured using commercial ELISA kits. Analysis of covariance was used to assess data at a significance level of 0.05 . 
Results: The eight-week core stability training was associated with a significant increase in serum level of progranulin (P=0.037) and a significant decrease in the level of TNF-α (P=0.000).
Conclusion: The findings indicate that the eight-week core stability training could significantly change serum levels of progranulin and TNF-α and improve the condition of women with MS. Therefore, this type of training could be applied as a complementary therapy for MS patients.
Full-Text [PDF 705 kb]   (165 Downloads)    
Research Article: Case Report | Subject: Sport Physiology
Received: 2020/08/10 | Accepted: 2020/09/12 | Published: 2021/01/1 | ePublished: 2021/01/1

References
1. 1) Shariati A, Latifi M, MajdiNasab N, Abad M, Abad AC. Collaborative care model effect on multiple sclerosis (MS) patients' lifestyle. Jundishapur Chron Dis Care. 2013; 2(3): 47-56. [Google Scholar]
2. 2) Pak F, Nafariyeh T, Asghari N, Shokrollahy M, Kokhaei P. Immunopathology of multiple sclerosis. Koomesh. 2013;14(2):117-29. (Persian) [View at Publisher] [Google Scholar]
3. 3) Inglese M. Multiple sclerosis: New insights and trends. Am J Neuroradiol. 2006;27(5):954-957. [PubMed] [Google Scholar]
4. 4) Ploeger HE, Takken T, De Greef MH, Timmons BW. The effects of acute and chronic exercise on inflammatory markers in children and adults with a chronic inflammatory disease: a systematic review. Exerc Immunol Rev. 2009;15(1): 6-41. [PubMed] [Google Scholar]
5. 5) khalil nejhad A, zahed nasab H, khodabande lo H, mahmodian E, azar abdar T, balood M, et al . Diagnostic Biomarkers in Multiple Sclerosis. sjimu. 2014; 21 (7) :288-311 [View at Publisher] [Google Scholar]
6. 6) Taoufik E, Tseveleki V, Euagelidou M, Emmanouil M, Voulgari-Kokota A, Haralambous S, et al. Positive and negative implications of tumor necrosis factor neutralization for the pathogenesis of multiple sclerosis. Neurodegenerative Diseases. 2008;5(1):32-37.DOI: 10.1159/000109936. [DOI:10.1159/000109936] [PubMed] [Google Scholar]
7. 7) Ong CH, Bateman A. Progranulin (granulinepithelin precursor, PC-cell derived growth factor,acrogranin) in proliferation and tumorigenesis. Histol Histopathol. 2003; 18(4): 1275-1288.DOI: 10.14670/HH-18.1275. [PubMed] [Google Scholar]
8. 8) Bhandari V, Bateman A. Structure and chromosomal location of the human granulin gene. Biochem Biophys Res Commun 1992; 188: 57-63. [DOI:10.1016/0006-291X(92)92349-3] [PubMed] [Google Scholar]
9. 9) Galimberti D, Bresolin N, Scarpini E. Chemokine network in multiple sclerosis: role in pathogenesis and targeting for future treatments. Expert Rev. Neurother. 2004;4:439-453. [DOI:10.1586/14737175.4.3.439] [Google Scholar]
10. 10) McDonald W, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol. 2001; 50(1): 121-127.doi: 10.1002/ana.1032. [DOI:10.1002/ana.1032] [PubMed] [Google Scholar]
11. 11) Daniel R, Daniels E, He Z, Bateman A. Progranulin (acrogranin/PC cell-derived growth factor/granulin-epithelin precursor) is expressed in the placenta, epidermis, microvasculature, and brain during murine development. Dev Dyn. 2003;227(4):593-599.doi: 10.1002/dvdy.10341. [DOI:10.1002/dvdy.10341] [PubMed] [Google Scholar]
12. 12) Kamei N, Tobe K, Suzuki R, Ohsugi M, Watanabe T, Kubota N, et al. Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance.J Biol Chem. 2006; 281(36): 26602-26614. doi: 10.1074/jbc.M601284200. [DOI:10.1074/jbc.M601284200] [PubMed] [Google Scholar]
13. 13) Jing H, Tan MS, Yu JT, Tan L.The Role of PGRN in Alzheimer's Disease.Mol Neurobiol. 2016;53(6):4189-4196. doi: 10.1007/s12035-015-9358-0. [DOI:10.1007/s12035-015-9358-0] [PubMed] [Google Scholar]
14. 14) Pirko I, Lucchinetti CF, Sriram S, Bakshi R. Gray matter involvement in multiple sclerosis. Neurology. 2007;68(9):634-642.doi: 10.1212/01.wnl.0000250267.85698.7a. [DOI:10.1212/01.wnl.0000250267.85698.7a] [PubMed] [Google Scholar]
15. 15) De Riz M, Galimberti D, Fenoglio C, Piccio LM, Scalabrini D, Venturelli E, et al.Cerebrospinal fluid progranulin levels in patients with different multiple sclerosis subtypes. Neurosci Lett. 2010;469(2):234-236.doi: 10.1016/j.neulet.2009.12.002. [DOI:10.1016/j.neulet.2009.12.002] [PubMed] [Google Scholar]
16. 16) Altmann C, Vasic V, Hardt S, Heidler J, Häussler A, Wittig I, et al. Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling.Mol Neurodegener. 2016;11(1):69. doi: 10.1186/s13024-016-0132-1. [DOI:10.1186/s13024-016-0132-1] [PubMed] [Google Scholar]
17. 17) Mostert S, Kesselring J. Effects of a short-term exercise training program on aerobic fitness, fatigue, health perception and activity level of subjects with multiple sclerosis.Mult Scler. 2002;8(2):161-168.doi: 10.1191/1352458502ms779oa. [DOI:10.1191/1352458502ms779oa] [PubMed] [Google Scholar]
18. 18) Kurdi M, anoosheh l, khodadadh S, khosravi N, Sangelaji b. The effect of selected combined training on strength, balance and life quality of multiple sclerosis patients. J sports med. 2011;2(2):51-64. (persian) [View at Publisher] [Google Scholar]
19. 19) Debolt ls, mccubbin ja. The effects of home based resistance exercise on balance, power, and mobility in adults with multiple sclerosis.Arch Phys Med Rehabil. 2004;85(2):290-297.doi: 10.1016/j.apmr.2003.06.003. [DOI:10.1016/j.apmr.2003.06.003] [PubMed] [Google Scholar]
20. 20) Amiri B, Sahebozamani M, Sedighi B. The effects of 10-week core stability training on balance in women with Multiple Sclerosis according to Expanded Disability Status Scale: a single-blinded randomized controlled trial.Eur J Phys Rehabil Med. 2019; 55(2): 199-208. doi: 10.23736/S1973-9087.18.04778-0. [DOI:10.23736/S1973-9087.18.04778-0] [PubMed] [Google Scholar]
21. 21) Alvarenga-Filho H, Sacramento PM, Ferreira TB, Hygino J, Abreu JE, Carvalho, SR, et al. Combined exercise training reduces fatigue and modulates the cytokine profile of T-cells from multiple sclerosis patients in response to neuromediators. J Neuroimmunol. 2016;293:91-99.doi: 10.1016/j.jneuroim.2016.02.014. [DOI:10.1016/j.jneuroim.2016.02.014] [PubMed] [Google Scholar]
22. 22) Jeffrey MW. Core stability training.J Strength Cond Res. 2007; 21(3): 979-985. doi: 10.1519/R-20255.1. [DOI:10.1519/R-20255.1] [PubMed] [Google Scholar]
23. 23) Chitramuthu BP, Bennett HP, Bateman A. Progranulin: a new avenue towards the understanding and treatment of neurodegenerative disease.Brain. 2017;140(12):3081-3104.doi: 10.1093/brain/awx198. [DOI:10.1093/brain/awx198] [PubMed] [Google Scholar]
24. 24) Nguyen AD, Nguyen TA, Martens LH, Mitic LL, Farese RV. Progranulin: At the interface of neurodegenerative and metabolic diseases.Trends Endocrinol Metab. 2013; 24(12): 597-606. doi: 10.1016/j.tem.2013.08.003. [DOI:10.1016/j.tem.2013.08.003] [PubMed] [Google Scholar]
25. 25) Jinlong Jian, Guangfei Li, Aubryanna Hettinghouse, Chuanju Liu. Progranulin: a key player in autoimmune diseases.Cytokine. 2018;101:48-55.doi: 10.1016/j.cyto.2016.08.007. [DOI:10.1016/j.cyto.2016.08.007] [PubMed] [Google Scholar]
26. 26) Cattaneo d, jonsdittor j, zocchi,m, regola a. Effects of balance exercises on people with mulitple sclerosis: a pilot study. Clin rehabil. 2007;21(9):771-781.DOI: 10.1177/0269215507077602. [DOI:10.1177/0269215507077602] [PubMed] [Google Scholar]
27. 27) Deckx N, Wens I, Nuyts AH, Hens N, de Winter BY, Koppen G, et al. 12 weeks of combined endurance and resistance training reduces innate markers of inflammation in a randomized controlled clinical trial in patients with multiple sclerosis. Med Inflam. 2016;20(16): 1485-1492.doi: 10.1155/2016/6789276. [DOI:10.1155/2016/6789276] [PubMed] [Google Scholar]
28. 28) Huang YM, Xiao BG, Özenci V, Kouwenhoven M, Teleshova N, Fredrikson S, et al. Multiple sclerosis is associated with high levels of circulating dendritic cells secreting pro-inflammatory cytokines. Neuroimmunol. 1999;99(1):82-90.doi: 10.1016/s0165-5728(99)00106-x. [DOI:10.1016/S0165-5728(99)00106-X] [PubMed] [Google Scholar]
29. 29) Elenkov IJ, Chrousos GP. Stress hormones, proinflammatory and antiinflammatory cytokines, and autoimmunity. Ann N Y Acad Sci. 2002;966:290-303.doi: 10.1111/j.1749-6632.2002.tb04229.x. [DOI:10.1111/j.1749-6632.2002.tb04229.x] [PubMed] [Google Scholar]
30. 30) Mokhtarzade M. The effect of aerobic interval training on leptin, adiponectin, TNF-a and interleukin 10 in women with multiple sclerosis (Masterˈs thesis). Ahvaz, Iran: Physical Education and Sport Science, Shahid Chamran University;2015; 74-76. [Persian]
31. 31) Arnett HA, Wang Y, Matsushima GK, Suzuki K, Ting JP. Functional genomic analysis of remyelination reveals importance of inflammation in oligodendrocyte regeneration.J Neurosci. 2003;23(30):9824-9832.doi: 10.1523/JNEUROSCI.23-30-09824.2003. [DOI:10.1523/JNEUROSCI.23-30-09824.2003] [PubMed] [Google Scholar]
32. 32) Kraszula Ł, Jasińska A, Eusebio MO, Kuna P, Głąbiński A, Pietruczuk M. Evaluation of the relationship between leptin, resistin, adiponectin and natural regulatory T cells in relapsing-remitting multiple sclerosis. Neurologia I Neurochirurgia Polska. 2012; 46(1):22-28. doi: 10.5114/ninp.2012.27211. [DOI:10.5114/ninp.2012.27211] [PubMed] [Google Scholar]
33. 33) Masudinejad M, Shirvani H. Effect of selected combined training program on leptin serum levels of men with multiple sclerosis. Sport Physiol Physic Activ. 2010;7(1):545-553. [Persian]

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


© 2007 All Rights Reserved | Medical Laboratory Journal