Volume 14, Issue 5 (Sep-Oct 2020)                   mljgoums 2020, 14(5): 35-41 | Back to browse issues page

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Yazdanian M, Moazzami M, Shabani M, Cheragh Birjandi S. The Effect of Eight-Week Aerobic Exercise before Cerebral Ischemia on the Expression of NT-3 and TrkC Genes in Male Rats. mljgoums 2020; 14 (5) :35-41
URL: http://mlj.goums.ac.ir/article-1-1235-en.html
The Effect of Eight-Week Aerobic Exercise before Cerebral Ischemia on the Expression of NT-3 and TrkC Genes in Male Rats
Mohtaram Yazdanian1 , Mahtab Moazzami 2, Mohammad Shabani3 , Sadegh Cheragh Birjandi4
1- MSc of exercise physiology, Department of Physical Education and Sport Sciences, , Islamic Azad University, Bojnourd Branch, Bojnord , Iran
2- Associate Professor in Sport Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran , mahtab.moazami@gmail.com
3- Department of Sport Sciences, University of Bojnord, Bojnord, Iran
4- Department of Sport Sciences, Islamic Azad University, Bojnourd Branch, Bojnourd, Iran
Abstract:   (2490 Views)
Background & Objective: Cerebral ischemia causes irreversible structural and functional damages in certain areas of the brain, especially the hippocampus. Evidence indicates that physical exercise may reduce the damages caused by cerebral ischemia. The purpose of this study was to examine the effect of 8-week exercise preconditioning on the expression of NT-3 and TrkC genes in the CA1 region of the hippocampus after the cerebral ischemic-reperfusion in male rats.
Methods: Twenty-one male Wistar rats weighing 250-300 gr were randomly selected and divided into three groups (healthy control, control + ischemia and exercise + ischemia). Rats in the exercise group ran on a treadmill 5 days per week for 8 weeks. Ischemia by occlusion of both common carotid arteries (CCA) was created for 45 minutes. In order to evaluate the gene expression, Real time PCR technique was used.
Findings: NT-3 gene expression was significantly different between exercise + ischemia with control + ischemia groups and control + ischemia with healthy control groups (P <0.05), and TrkC gene expression was significantly different between exercise + ischemia with healthy control groups and control + ischemia with healthy control groups (P <0.05).
Conclusion: The results of this study demonstrated that exercise before the induction of ischemic stroke increased the NT-3 gene expression but did not influence the TrKC gene expression.
 
Keywords: Aerobic Exercise, Cerebral Ischemia, Neurotrophin 3 (NT-3), tyrosine kinase C (TrkC)
Full-Text [PDF 908 kb]   (561 Downloads)    
Research Article: Original Paper | Subject: Sport Physiology
Received: 2019/07/29 | Accepted: 2019/09/1 | Published: 2020/08/24 | ePublished: 2020/08/24
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