Mon, May 26, 2025
Volume 18, Issue 4 (Jul-Aug 2024)
mljgoums 2024, 18(4): 11-13 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Ahmed E M A A, Mohamed B A, Nour B Y M, Almugadam B S. Correlation between platelet counts, MPV, PDW, PCT and age in acute ischemic stroke patients. mljgoums 2024; 18 (4) :11-13
URL: http://mlj.goums.ac.ir/article-1-1650-en.html
URL: http://mlj.goums.ac.ir/article-1-1650-en.html
Ebrahim Mohammed Abed Ahamid Ahmed1 
, Babker Ahmed Mohamed2 , Bakri Yousf Mohamed Nour3 , Babiker Saad Almugadam4
, Babker Ahmed Mohamed2 , Bakri Yousf Mohamed Nour3 , Babiker Saad Almugadam4
1- Department of Hematology and Immunohematology, Faculty of Medical Laboratory Sciences, University of Gezira, Wadmedani, Sudan ; Kosti Teaching Hospital, Kosti, Sudan
2- Department of Pathology, Faculty of Medicine, Karari University, Khartoum, Sudan ,babikjuba54@gmail.com
3- Department of Parasitology, Faculty of Medical Laboratory Sciences, University of Gezira, Wadmedani, Sudan
4- Department of Microbiology, Faculty of Medical Laboratory Sciences, University of El Imam El Mahdi, Kosti, Sudan
2- Department of Pathology, Faculty of Medicine, Karari University, Khartoum, Sudan ,
3- Department of Parasitology, Faculty of Medical Laboratory Sciences, University of Gezira, Wadmedani, Sudan
4- Department of Microbiology, Faculty of Medical Laboratory Sciences, University of El Imam El Mahdi, Kosti, Sudan
Abstract: (1043 Views)
Background: Acute ischemic stroke occurs when blood clots obstruct blood vessels within the brain. Platelets (Plts) are integral to the pathophysiology of stroke. This research aimed to explore the relationship between Plt quality and Plt indices in the context of acute ischemic stroke.
Methods: This cross-sectional investigation involved 100 patients diagnosed with acute ischemic stroke at Kosti Teaching Hospital and Alyammama Hospitals. The diagnosis was confirmed using brain CT imaging and electrocardiography (ECG). Blood samples were collected in EDTA-containing tubes within 24 hours following the commencement of treatment and were subsequently analyzed for Plt count, mean Plt volume (MPV), Plt distribution width (PDW), and plateletcrit (PCT) utilizing a hematological analyzer. Data were analyzed using GraphPad Prism software.
Results: Platelet counts negatively correlated with PDW [r=-0.074, P=0.459; R=-0.023, P=0.815], MPV [r=-0.130, P=0.194; R=-0.081, P=0.417], and diastolic blood pressure [r= -0.023, P=0.818; R= -0.024, P=0.805]; and positively correlated with PCT [r= 0.103, P=0.308; R=0.143, P=0.155] and diastolic blood pressure [r=0.022, P=0.823; R= 0.008, P=0.932]. Moreover, PDW positively correlated with systolic blood pressure [r=0.105, P=0.298; R= 0.147, P=0.148] and diastolic blood pressure [r=0.146, P=0.145; R=0.173, P=0.084]. Based on Spearman but not Pearson correlation, PDW showed a negative correlation with PCT [r=-0.005, P=0.959; R=0.010, P=0.929].
Conclusion: The study shows a correlation between Plt count and indices in ischemic stroke patients. The research also presented evidence concerning the relationship between diastolic and systolic blood pressure and Plt counts and indices.
Methods: This cross-sectional investigation involved 100 patients diagnosed with acute ischemic stroke at Kosti Teaching Hospital and Alyammama Hospitals. The diagnosis was confirmed using brain CT imaging and electrocardiography (ECG). Blood samples were collected in EDTA-containing tubes within 24 hours following the commencement of treatment and were subsequently analyzed for Plt count, mean Plt volume (MPV), Plt distribution width (PDW), and plateletcrit (PCT) utilizing a hematological analyzer. Data were analyzed using GraphPad Prism software.
Results: Platelet counts negatively correlated with PDW [r=-0.074, P=0.459; R=-0.023, P=0.815], MPV [r=-0.130, P=0.194; R=-0.081, P=0.417], and diastolic blood pressure [r= -0.023, P=0.818; R= -0.024, P=0.805]; and positively correlated with PCT [r= 0.103, P=0.308; R=0.143, P=0.155] and diastolic blood pressure [r=0.022, P=0.823; R= 0.008, P=0.932]. Moreover, PDW positively correlated with systolic blood pressure [r=0.105, P=0.298; R= 0.147, P=0.148] and diastolic blood pressure [r=0.146, P=0.145; R=0.173, P=0.084]. Based on Spearman but not Pearson correlation, PDW showed a negative correlation with PCT [r=-0.005, P=0.959; R=0.010, P=0.929].
Conclusion: The study shows a correlation between Plt count and indices in ischemic stroke patients. The research also presented evidence concerning the relationship between diastolic and systolic blood pressure and Plt counts and indices.
Research Article: Research Article |
Subject:
Laboratory hematology
Received: 2023/04/3 | Accepted: 2023/09/26 | Published: 2025/03/11 | ePublished: 2025/03/11
Received: 2023/04/3 | Accepted: 2023/09/26 | Published: 2025/03/11 | ePublished: 2025/03/11
References
1. Arikanoglu A, Yucel Y, Acar A, Cevik MU, Akil E, Varol S, Tasdemir N. The relationship of the mean platelet volume and C-reactive protein levels with mortality in ischemic stroke patients. European Review for Medical and Pharmacological Sciences. 2013; 17(13):1774-1777. [View at Publisher] [PMID] [Google Scholar]
2. Baburhan G, Ozkan H, Kabayel L. Mean platelet volume and peripheral blood count response in acute ischemic stroke. Trakya Universitesi Tip Fakultesi Dergisi. 2008; 25(2): 130-135. [View at Publisher] [Google Scholar]
3. Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis. 1996; 7: 157-161. [View at Publisher] [DOI] [Google Scholar]
4. Berger JS, Eraso LH, Xie D, Sha D, Mohler ER. Mean platelet volume and prevalence of peripheral artery disease, the National Health and Nutrition Examination Survey. 2000, 1999-2004. [View at Publisher] [DOI] [Google Scholar]
5. Bianca L, Huwae S, Kaelan C, Muis A, Ilmu B, Saraf P, Hasanuddin U. Hubungan Kadar Neutrofil Dengan Luaran Klinis Penderita Strok Iskemik Akut. Universitas Hasanuddin Makassar. thesis. 2012. [View at Publisher]
6. Du J, Wang Q, He B, Liu P, Chen JY, Quan H, et al. Association of mean platelet volume and platelet count with the development and prognosis of ischemic and hemorrhagic stroke. International Journal of Laboratory Hematology. 2016; 38(3): 233-239. [View at Publisher] [DOI] [PMID] [Google Scholar]
7. Voronov R, Muthard RW, Tomaiuolo M, Diamond SL. A systems approach to hemostasis: 1. The interdependence of thrombus architecture and agonist movements in the gaps between platelets. Blood. 2014; 124(11): 1808-1815. [View at Publisher] [DOI] [PMID] [Google Scholar]
8. Yeung J, Hawley M, Holinstat M. The expansive role of oxylipins on platelet biology. Journal of Molecular Medicine. 2017; 95(6): 575-588. [View at Publisher] [DOI] [PMID] [Google Scholar]
9. Holinstat M, Tourdot BE. Coronary heart disease risk factors take a disproportional toll on women. Arteriosclerosis, Thrombosis, and Vascular Biology. 2015; 35(4): 750-751. [View at Publisher] [DOI] [PMID] [Google Scholar]
10. Koupenova M, Mick E, Mikhalev E, Benjamin EJ, Tanriverdi K, Freedman JE. Sex differences in platelet toll-like receptors and their association with cardiovascular risk factors. Arteriosclerosis, Thrombosis, and Vascular Biology. 2015; 35(4): 1030-1037. [View at Publisher] [DOI] [PMID] [Google Scholar]
11. Ouseph MM, Huang Y, Banerjee M, Joshi S, MacDonald L, Zhong Y. Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis. Blood. 2015; 126(10): 1224-1233. [View at Publisher] [DOI] [PMID] [Google Scholar]
12. Sadeghi F, Kovács S, Zsóri KS, Csiki Z, Bereczky Z, Shemirani AH. Platelet count and mean volume in acute stroke: a systematic review and meta-analysis. Platelets. 2020; 31(6): 731-9. [View at Publisher] [DOI] [PMID] [Google Scholar]
13. Kaito K, Otsubo H, Usui N, Yoshida M, Tanno J, Kurihara E, et al. Platelet size deviation width, platelet large cell ratio, and mean platelet volume have sufficient sensitivity and specificity in the diagnosis of immune thrombocytopenia. 2005; 128: 698-702 . [View at Publisher] [DOI] [PMID] [Google Scholar]
14. Borkataky S, Jain R, Gupta R, Singh S, Krishan G, Gupta K, et al. Role of platelet volume indices in the differential diagnosis of thrombocytopenia:A simple and inexpensive method Hematology. 2009; 14 :182 6 [View at Publisher] [DOI] [PMID] [Google Scholar]
15. Lanzkowsky's Manual of Pediatric Hematology and Oncology. Elsevier. 2016; Chapter 14-Disorders of Platelets, 6th ed, 239. [View at Publisher] [DOI] [Google Scholar]
16. Al-Tameemi WF, Ameen2 AMM. Significance of Platelet Indices in Patients with Acute Ischemic Stroke.IRAQI J MED SCI. 2012; 10(4):383-389 [View at Publisher] [Google Scholar]
17. Zhang J, Mingyong Li, Yuan H. Large population study for age- and gender- related variations of platelet indices in Southwest China healthy adults. Hematol Transfus Int J. 2015;1(4):108-114 [View at Publisher] [DOI]
18. Yang K, Tao L, Mahara G, Yan Y, Cao K, Liu X, et al. An association of platelet indices with blood pressure in Beijing adults: Applying quadratic inference function for a longitudinal study. Medicine (Baltimore). 2016; 95(39): e4964. [View at Publisher] [DOI] [PMID] [Google Scholar]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Enamad
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.