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W J. Creatine kinase as a supportive test in thyroid disorders. mljgoums 2024; 18 (2) :8-10
URL: http://mlj.goums.ac.ir/article-1-1639-en.html
URL: http://mlj.goums.ac.ir/article-1-1639-en.html
Department of Biochemistry, ACS Medical College and Hospital, Maduravoyal, Chennai, India;Dr. MGR Education and Research Institute, Chennai, India , jincynancy1994@gmail.com
Abstract: (470 Views)
Background: Musculoskeletal disorders are common in patients with hypothyroidism, and are also observed in thyrotoxicosis. Creatine kinase (CK) is present in the muscles and is involved in energy metabolism. This study aimed to estimate the serum CK levels in patients with hypothyroidism, hyperthyroidism, and healthy individuals. Moreover, the correlation of CK levels with markers of thyroid function is assessed.
Methods: A total of 120 patients with hypothyroid and 120 with hyperthyroid were compared with 120 healthy individuals aged 20-60 years. The thyroid status was assessed by determining the serum thyroid-stimulating hormone (TSH) and free thyroxine (fT4) using chemiluminescent immunoassay. Serum CK was measured the by kinetic method. Statistical analysis was performed by analysis of variance and Pearson’s correlation to investigate the correlations between CK and thyroid hormones.
Results: A significant increase (P<0.0001) and a significant decrease (P<0.0001) in serum CK were observed in hypothyroid patients (253.98±129.04 IU/L) and in hyperthyroid patients (34.68±13.15 IU/L), respectively, compared to the control group (72.9±29.01 IU/L). A negative correlation was found between fT4 and CK (r: -0.4253, P<0.0005).
Conclusion: It could be concluded that CK activity in serum may be a useful additional test in thyroid disorders.
Methods: A total of 120 patients with hypothyroid and 120 with hyperthyroid were compared with 120 healthy individuals aged 20-60 years. The thyroid status was assessed by determining the serum thyroid-stimulating hormone (TSH) and free thyroxine (fT4) using chemiluminescent immunoassay. Serum CK was measured the by kinetic method. Statistical analysis was performed by analysis of variance and Pearson’s correlation to investigate the correlations between CK and thyroid hormones.
Results: A significant increase (P<0.0001) and a significant decrease (P<0.0001) in serum CK were observed in hypothyroid patients (253.98±129.04 IU/L) and in hyperthyroid patients (34.68±13.15 IU/L), respectively, compared to the control group (72.9±29.01 IU/L). A negative correlation was found between fT4 and CK (r: -0.4253, P<0.0005).
Conclusion: It could be concluded that CK activity in serum may be a useful additional test in thyroid disorders.
Research Article: Original Paper |
Subject:
Biochemistry
Received: 2023/03/6 | Accepted: 2024/04/6 | Published: 2024/04/28 | ePublished: 2024/04/28
Received: 2023/03/6 | Accepted: 2024/04/6 | Published: 2024/04/28 | ePublished: 2024/04/28
References
1. Jungare Sh, Jungare A, Sonone S. Evaluation of Role of Creatine Kinase Activity as a Diagnostic Tool for Thyroid Function. Int J Rec TrendsSci Tech. 2013; 7:60-62. [View at Publisher]
2. Pandey R, Jaiswal S, Sah JP, Bastola K, Dulal S. Assessment of Serum Enzymes Level in Patients with Thyroid Alteration Attending Manipal Teaching Hospital, Pokhara. A J Life Sci. 2013; 3:1-9. [View at Publisher] [Google Scholar]
3. Guyton AC. Endocrinology and reproduction. In: Elsevier saunders(Ed) Thyroid metabolic hormones.Text book of medical physiology, 2006: p 936. [View at Publisher] [Google Scholar]
4. Panicker V. Genetics of thyroid function and disease. Clin Biochem Rev. 2011; 32(4): 165-75. [View at Publisher] [Google Scholar]
5. KlaudiaBrix, Dagmar Fuhrer, Heike Biebermann. Molecules important for thyroid hormone synthesis and action - known facts and future perspectives. Thyroid Research. 2011; 4:1-6. [View at Publisher] [DOI] [PMID] [Google Scholar]
6. Williams GR. Thyroid hormone actions in cartilage and bone. Eur Thyroid J. 2013; 2(1): 3-13. [View at Publisher] [DOI] [PMID] [Google Scholar]
7. KMDS Panag, Gitanjali, SudeepGoyal. Evaluation of Creatine Kinase as a Diagnostic Tool for Thyroid Function. In JClin Practice. 2012; 23:221-23. [View at Publisher] [Google Scholar]
8. Burtis CA, Ashwood ER, David E. Bruns.Analytes. In: Mauro Panteghini (Eds) Serum enzymes.Teitz Fundamentals of Clinical Chemistry,2001: pp569-72. [View at Publisher]
9. Hernando P, Caramelo C, López Garcia D, Hernando L. Muscle cramps: a cause of elevated creatine kinase levels in hemodialysis patients. Nephron. 1990; 55(2): 231-2. [View at Publisher] [DOI] [PMID] [Google Scholar]
10. Eppenberger HM, Dawson DM, Kaplan NO. The comparative enzymology of creatine kinases. I. Isolation and characterization from chicken and rabbit tissues. J Biol Chem. 1967 ;242(2):204-9. [View at Publisher] [DOI] [PMID] [Google Scholar]
11. Wallimann T, Wyss M, Brdiczka D, Nicolay K, Eppenberger HM. EPPENBERGER. Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasis. Biochm J.1992; 281:21-40. [View at Publisher] [DOI] [PMID] [Google Scholar]
12. VASSELLA F, RICHTERICH R, ROSSI E. The diagnostic value of serum creatine kinase in neuromuscular and muscular disease. Pediatrics. 2016; 322-30. [View at Publisher] [DOI] [PMID] [Google Scholar]
13. Archana Prakash, AK Lal, KS Negi. Serum Creatine Kinase Activity in Thyroid Disorders. JK Sci. 2007 Jan-Mar; 9: 25-26. [View at Publisher] [Google Scholar]
14. DA McGrowder, YP Fraser, L Gordon, TV Crawford, JM Rawlins. Serum creatine kinase and lactate dehydrogenase activities in patients with thyroid disorders. Nig J ClinPrac. 2011; 14: 455-59. [View at Publisher] [DOI] [PMID] [Google Scholar]
15. Griffiths PD. Serum enzymes in diseases of the thyroid gland. J Clin Pathol. 1965; 18(5): 660-3. [View at Publisher] [DOI] [PMID] [Google Scholar]
16. RashmiRanka, RatiMathur. Serum creatine phosphokinase in thyroid disorders. In J ClinBiochem. 2003; 18:107-110. [View at Publisher] [DOI] [PMID] [Google Scholar]
17. Hekimsoy Z, Oktem IK. Serum creatine kinase levels in overt and subclinical hypothyroidism. Endocr Res. 2005; 31:171-5. [View at Publisher] [DOI] [PMID] [Google Scholar]
18. Kelvin R Scott, Simons Z, Boyer PJ. Hypothyroid myopathy with a strikingly elevated serum creatine kinase level. Muscle and nerve. 2002; 26:141-4. [View at Publisher] [DOI] [PMID] [Google Scholar]
19. Docherty I, Harrop JS, Hine KR, Hopton MR, Matthews HL, Taylor CJ. Myoglobin concentration, creatine kinase activity, and creatine kinase B subunit concentrations in serum during thyroid disease. Clin Chem. 1984; 30(1): 42-5. [View at Publisher] [DOI] [PMID] [Google Scholar]
20. Rongen HA, Hoetelmans RM, Bult A, van Bennekom WP. Chemiluminescence and immunoassays. J Pharm Biomed Anal. 1994; 12: 433-62. [View at Publisher] [DOI] [PMID] [Google Scholar]
21. Schumann G, Canalias F, Joergensen PJ, Kang D, Lessinger JM, Klauke R, Committee On Reference Systems For Enzymes C-Rse, International Federation of Clinical Chemistry and Laboratory Medicine Scientific Division. IFCC reference procedures for measurement of the catalytic concentrations of enzymes: corrigendum, notes and useful advice. International Federation of Clinical Chemistry and Laboratory Medicine (IFCC)--IFCC Scientific Division. Clin Chem Lab Med. 2010;48(5):615-21. [View at Publisher] [DOI] [PMID] [Google Scholar]
22. Yasin A. Baqir YA, Abdul-Khader A, Naama LM. Serum creatine kinase activity in thyroid dysfunction. Bas J Surg. 2013; 2: 167-170. [View at Publisher] [DOI]
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