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mljgoums 2021, 15(5): 13-18 |
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Zarrabi Ahrabi N, souldozi A, SarveAhrabi Y. Synthesis of New Three-Component Derivatives of 1, 3, 4-Oxadiazole and Evaluation of Their In Vitro Antibacterial and Antifungal Properties. mljgoums 2021; 15 (5) :13-18
URL: http://mlj.goums.ac.ir/article-1-1308-en.html
URL: http://mlj.goums.ac.ir/article-1-1308-en.html
1- Department of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
2- Department of Chemistry, Urmia Branch, Islamic Azad University, Urmia, Iran
3- Department of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran ,yasin.ahrabi2016@gmail.com
2- Department of Chemistry, Urmia Branch, Islamic Azad University, Urmia, Iran
3- Department of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran ,
Abstract: (3920 Views)
Background and objectives: Antibiotic resistance is a major public health challenge. The pervasive antibiotic misuse can lead to increased antibiotic resistance. Thus, there is a need for discovery of new compounds against drug-resistant microorganisms. We synthesized new series of 1, 3, 4-oxadiazole derivatives (4a-4d) and evaluated the antibacterial and antifungal activity of the derivatives against Staphylococcus aureus, Staphylococcus epidermidis, Acinetobacter baumannii, Klebsiella pneumoniae, Aspergillus fumigatus and Aspergillus flavus.
Methods: The new derivatives of 1, 3, 4-oxadiazole were synthesized using a single-stage, high-yield method. The structure of the new compounds was confirmed by infrared spectroscopy, carbon-nuclear magnetic resonance and hydrogen- nuclear magnetic resonance. Then, antibacterial and antifungal activities of the prepared derivatives (1 mg/ml) were evaluated by determining minimum inhibitory concentration and minimum bactericidal/fungicidal concentration using the agar well diffusion method.
Results: All synthesized compounds, especially (4d) with methoxyphenyl group, exhibited powerful antibacterial activity against the tested bacteria. However, the compounds had no antifungal effect.
Conclusion: Our findings indicate the antibacterial potential of the novel synthetic 1, 3, 4-oxadiazole compounds.
Methods: The new derivatives of 1, 3, 4-oxadiazole were synthesized using a single-stage, high-yield method. The structure of the new compounds was confirmed by infrared spectroscopy, carbon-nuclear magnetic resonance and hydrogen- nuclear magnetic resonance. Then, antibacterial and antifungal activities of the prepared derivatives (1 mg/ml) were evaluated by determining minimum inhibitory concentration and minimum bactericidal/fungicidal concentration using the agar well diffusion method.
Results: All synthesized compounds, especially (4d) with methoxyphenyl group, exhibited powerful antibacterial activity against the tested bacteria. However, the compounds had no antifungal effect.
Conclusion: Our findings indicate the antibacterial potential of the novel synthetic 1, 3, 4-oxadiazole compounds.
Research Article: Original Paper |
Subject:
Microbiology
Received: 2020/08/3 | Accepted: 2021/05/22 | Published: 2021/08/31 | ePublished: 2021/08/31
Received: 2020/08/3 | Accepted: 2021/05/22 | Published: 2021/08/31 | ePublished: 2021/08/31
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