Volume 13, Issue 1 (Jan-Feb 2019)                   mljgoums 2019, 13(1): 12-14 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Salar amoli S, Besharat S, Emami razavi A N, Ayatollahi A, Joshaghani H. Lack of Association between Selenium Level and Human Epidermal Growth Factor Receptor 2 (HER2) Expression in Breast Cancer Tissue. mljgoums. 2019; 13 (1) :12-14
URL: http://mlj.goums.ac.ir/article-1-1104-en.html
1- cancer research center,Golestan University of Medical Sciences, Gorgan,Iran
2- cancer research center,Tehran University of Medical Sciences, Tehran, Iran
3- Golestan University of Medical Sciences, Medical Laboratory Sciences Research Center, Gorgan, Iran
4- Golestan University of Medical Sciences, Medical Laboratory Sciences Research Center, Gorgan, Iran , Hr_joshaghani@yahoo.com
Abstract:   (6174 Views)

Background and Objective: HER-2 (human epidermal growth factor receptor 2) is one such gene that can play a role in the development of breast cancer by making HER-2 proteins (receptorson breast cells). Normally, HER-2 receptors control breast cells grow and Division.  HER-2 protein over expression is the cause of up to 20% of breast cancers. The phosphoinositide 3 kinase (PI3K) pathway is important in the oncogenic function of HER-2. 

It has been reported compounds including Se, such as selenite significantly attenuated oxidative-stress-induced activation of the PI3K signaling pathways and can exhibit antitumor activity by downregulating PI3K activation.

 In this study, we evaluated Association of tissue selenium level and Human epidermal growth factor receptor 2 (HER-2) expression in breast cancer.

methods:

Se contents and expression of HER-2 were determined in 30 tissue collected from 30 women diagnosed with breast cancer based on immunohistochemistry (HER-2) and atomic absorption (Se).

Results:

About 30% of the samples were positive for HER-2 expression. Mean level of tissue selenium in tumors for positive and negative HER-2 was 268.15 µg/l and 206.43µg/l respectively. So, there was no significant association between selenium level and HER-2 expression. (p>0.005)

Conclusion:

There is no Association of tissue selenium level and HER-2 expression in breast cancer.

Keyword:

Selenium, HER-2, breast cancer

Full-Text [PDF 493 kb]   (855 Downloads)    
Type of Study: Original Paper |
Received: 2018/07/12 | Accepted: 2018/07/12 | Published: 2018/07/12 | ePublished: 2018/07/12

References
1. Chen YC, Prabhu KS, Das A, Mastro AM. Dietary selenium supplementation modifies breast tumor growth and metastasis. Int J Cancer. 2013; 133(9): 2054-64. doi: 10.1002/ijc.28224. [DOI:10.1002/ijc.28224]
2. Huang HJ, Lee KJ, Yu HW, Chen CY, Hsu CH, Chen HY, et al. Structure-based and ligand-based drug design for HER 2 receptor. J Biomol Struct Dyn. 2010; 28(1): 23-37. [DOI:10.1080/07391102.2010.10507341]
3. Hou Y, Nitta H, Li Z. HER2 Gene Protein Assay Is Useful to Determine HER2 Status and Evaluate HER2 Heterogeneity in HER2 Equivocal Breast Cancer. Am J Clin Pathol. 2017; 147(1): 89-95. doi: 10.1093/ajcp/aqw211. [DOI:10.1093/ajcp/aqw211]
4. Dorgan JF, Sowell A, Swanson CA, Potischman N, Miller R, Schussler N, et al. Relationships of serum carotenoids, retinol, alpha-tocopherol, and selenium with breast cancer risk: results from a prospective study in Columbia, Missouri (United States). Cancer Causes Control. 1998; 9(1): 89-97. [DOI:10.1023/A:1008857521992]
5. Medina D. Mechanisms of selenium inhibition of tumorigenesis. J Am Coll Toxicol. 1986; 5: 21-7. [DOI:10.3109/10915818609140733]
6. Burk RF. Selenium in Nutrition and Healthedited by PF Surai, 2006, 974 pages, hardcover, $149. Nottingham University Press, Nottingham, United Kingdom. The American Journal of Clinical Nutrition. 2007; 86(1): 270. [DOI:10.1093/ajcn/86.1.270]
7. Zeng H, Combs GF Jr. Selenium as an anticancer nutrient: roles in cell proliferation and tumor cell invasion. J Nutr Biochem. 2008; 19(1): 1-7. [DOI:10.1016/j.jnutbio.2007.02.005]
8. Lee SO, Nadiminty N, Wu XX, Lou W, Dong Y, Ip C, et al. Selenium Disrupts Estrogen Signaling by Altering Estrogen Receptor Expression and Ligand Binding in Human Breast Cancer Cells. Cancer Research. 2005; 65(8): 3487-92. [DOI:10.1158/0008-5472.CAN-04-3267]
9. Kim SJ, Uehara H, Karashima T, Mccarty M, Shih N, Fidler IJ. Expression of interleukin-8 correlates with angiogenesis, tumorigenicity, and metastasis of human prostate cancer cells implanted orthotopically in nude mice. Neoplasia. 2001; 3: 33-42. [DOI:10.1038/sj.neo.7900124]
10. Khandelwal S, Gollahon L, Spallholz J, Boylan M, Garcia-Hernandez MDM. Abstract 4613: Cytotoxicity of selenium trastuzumab and bevacizumab immunoconjugates against triple negative breast cancer cells. Cancer Research. 2017; 77(13 Supplement): 4613. [DOI:10.1158/1538-7445.AM2017-4613]
11. Qi Y, Fu X, Xiong Z, Zhang H, Hill SM, Rowan BG, et al. Methylseleninic Acid Enhances Paclitaxel Efficacy for the Treatment of Triple-Negative Breast Cancer. PLoS ONE. 2012; 7(2): e31539. doi: 10.1371/journal.pone.0031539. [DOI:10.1371/journal.pone.0031539]
12. Guo CH, Hsia S, Shih MY, Hsieh FC, Chen PC. Effects of Selenium Yeast on Oxidative Stress, Growth Inhibition, and Apoptosis in Human Breast Cancer Cells. Int J Med Sci. 2015; 12(9): 748-58. [DOI:10.7150/ijms.12177]
13. Chen YC, Prabhu KS, Das A, Mastro AM. Dietary selenium supplementation modifies breast tumor growth and metastasis. Int J Cancer. 2013; 133(9): 2054-64. [DOI:10.1002/ijc.28224]
14. Schrauzer GN, Molenaar T, Mead S, Kuehn K, Yamamoto H, Araki E. Selenium in the blood of Japanese and American women with and without breast cancer and fibrocystic disease. Jpn J Cancer Res. 1985; 76: 374-7.
15. Dorgan JF, Sowell A, Swanson CA, Potischman N, Miller R, Schussler N, et al. Relationships of serum carotenoids, retinol, alpha-tocopherol, and selenium with breast cancer risk: results from a prospective study in Columbia, Missouri (United States). Cancer Causes Control. 1998; 9(1): 89-97. [DOI:10.1023/A:1008857521992]
16. van den Brandt PA1, Goldbohm RA, van't Veer P, Bode P, Dorant E, Hermus RJ, et al. Toenail selenium levels and the risk of breast cancer. Am J Epidemiol. 1994;140:20-6 [DOI:10.1093/oxfordjournals.aje.a117155]
17. van't Veer P, van der Wielen RP, Kok FJ, et al. Selenium in diet, blood, and toenails in relation to breast cancer: a case-control study. Am J Epidemiol. 1990; 131(6): 987-94 [DOI:10.1093/oxfordjournals.aje.a115619]

Add your comments about this article : Your username or Email:
CAPTCHA code

Send email to the article author


© 2007 All Rights Reserved | Medical Laboratory Journal