Molecular detection of hepatitis delta virus in blood donors with RT-PCR

Malekpour, B.,; Tajbakhsh, E,; Khamesipour, F,; Rahimi, A,

Volume 9, Issue 2 (may,jun 2015[PERSIAN] 2015) mljgoums 2015, 9(2): 26-31 | Back to browse issues page

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Malekpour, B., Tajbakhsh, E, Khamesipour, F, Rahimi, A. Molecular detection of hepatitis delta virus in blood donors with RT-PCR. mljgoums 2015; 9 (2) :26-31
URL: http://mlj.goums.ac.ir/article-1-742-en.html

Molecular detection of hepatitis delta virus in blood donors with RT-PCR

Malekpour, B.

, Tajbakhsh, E

¹, Khamesipour, F

, Rahimi, A

1- , ee_tajbakhsh@yahoo.com

Abstract: (12402 Views)

Abstract

Background and Objective: Hepatitis delta virus is an imperfect virus with RNA and its activity depends on the presence of hepatitis B virus. This virus can lead to acute and chronic diseases in the liver. This study aimed to detect the hepatitis delta virus in blood donors with positive Hepatitis B Surface Antigens (HBsAg).

Material and Methods: In this Study, 350 serum samples were obtained from the people infected with hepatitis B blood in Transfusion organization of Shahrekord city, Iran. After extracting RNA by RNA Plus kit and making cDNA, the samples were evaluated by using RT PCR.

Results: Of 350, two samples (0.57%) were infected by HDV.

Conclusion: Low prevalence of HDV infection shows that Hepatitis B is being controlled in Shahrekord.

Keywords: Hepatitis Delta Virus, Blood Donors, Hepatitis B Surface Antigens