Volume 9, Issue 2 (may,jun 2015[PERSIAN] 2015)                   mljgoums 2015, 9(2): 78-84 | Back to browse issues page

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Razaz Rahmati, N, Mohabati Mobarez, A, Khoram Abadi, N, Sharifzade peyvasti, V, Shokoohizade, L. Antibiotic Susceptibility of Staphylococcus aureus and Enterococcus Spp. Isolated from some Hospitals in Tehran. mljgoums 2015; 9 (2) :78-84
URL: http://mlj.goums.ac.ir/article-1-685-en.html
1- Tarbiat Modares University, Tehran, Iran
2- Department of Bacteriology, Tarbiat Modares University, Tehran, Iran , mmmobarez@modares.ac.ir
3- Department of Bacteriology, Tarbiat Modares University, Tehran, Iran
4- Department of Medical Laboratory, School of Paramedicin, Jundishapur University of Medical Sciences, Ahvaz, Iran
Abstract:   (15237 Views)

Abstract

Background and Objective: Vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) are the leading nosocomial pathogens in Iran. We aimed at evaluating the resistance patterns of Staphylococcus aureus and enterococci to the antibiotics recommended by Clinical and Laboratory Standards Institute (CLSI).

Material and Methods: Two-hundred forty Staphylococcus aureus and 203 Enterococcus isolated from urine, wound, blood, trachea, stool and other clinical specimens of inpatients and outpatients were obtain from some hospitals in Tehran. Sensitivity of S. aureus to oxacillin, vancomycin, chloramphenicol, nitrofurantoin, erythromycin, clindamycin and linezolid were determined by disk diffusion according to CLSI (M100-S22) guidelines. Likewise, sensitivity of enterococci to ampicillin, vancomycin, teicoplanin, tigecycline, linezolid, tetracycline, chloramphenicol and nitrofurantoin was invesditated by the same method.

Results: Of 240 S. aureus isolates, 56%, 46.6% and 40.4%were resistant to oxacillin, erythromycin and clindamycin, respectively. We found one S. aureus isolate with low   susceptibility to vancomycin (VISA; 0.5%). All S. aureus isolates were sensitive to chloramphenicol, nitrofurantoin and linezolid. Of 203 Enterococcus spp., 47.3%, 24.6%, 9.4%, 85.2%, 11.3% and 4.4% were resistant to ampicillin, vancomycin, teicoplanin, tetracycline, chloramphenicol and nitrofurantoin, respectively. All these isolates were sensitivity  to tigecycline and linezolid.

Conclusion: Resistance of S. aureus isolates to oxacillin, erythromycin and clindamycin was significant. Enterococci isolates were remarkably resistant to ampicillin, vancomycin, teicoplanin, tetracycline, chloramphenicol and nitrofurantoin. Given our results, we suggest vancomycin, chloramphenicol, linezolid and nitrofurantoin for S. aureus infections and tigecycline and linezolid as drugs of choice for enterocoocal infections treatment.

Keywords: Staphylococcus aureus, Enterococcus, Tehran, Hospitals

Research Article: Original Paper |
Received: 2015/07/21 | Accepted: 2015/07/21 | Published: 2015/07/21 | ePublished: 2015/07/21

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.