The Assessment of Erythrocyte Reduced Glutathione Concentration in the Neonates suffered from G6PD Deficiency

Rafeemehr, H

Volume 7, Issue 4 (winter[PERSIAN] 2014) mljgoums 2014, 7(4): 9-12 | Back to browse issues page

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Rafeemehr H. The Assessment of Erythrocyte Reduced Glutathione Concentration in the Neonates suffered from G6PD Deficiency. mljgoums 2014; 7 (4) :9-12
URL: http://mlj.goums.ac.ir/article-1-338-en.html

The Assessment of Erythrocyte Reduced Glutathione Concentration in the Neonates suffered from G6PD Deficiency

H Rafeemehr

Assistant Professor of Hematology, Department of Medical Laboratory Sciences, Faculty of Paramedicine, Hamedan University of Medical Sciences, Hamedan, Iran , rafee_1352@yahoo.com

Abstract: (26340 Views)

Abstract Background and Objective: Glutathione as a master antioxidant plays a key role in eliminating free radicals from your body and in preserving cell membrane integrity esp. blood cells. We aimed to assess the Erythrocyte Glutathione level of favism and non-favism neonates. Material and Methods: This study was conducted in Ekbatan hospitals of Hamadan (2009) on 15 favism patients and 60 non-favism ones matched by sex and age. Using Beutler method, the reduced Glutathione (GSH) level of red blood cells was measured. Results: Based on the results, the amount of erythrocyte GSH in favism patients was 14.99±4.62 mg/dl and that of controls was 58.2±10.59 mg/dl. Conclusion: the results show that the erythrocyte GSH in favism patients is significantly lower than that of non-favism subjects therefore, the former seems more likely to be afflicted by hemolytic crises owing to the use of oxidant stuff. Keywords: Favism Glutathone Neonates G6PD

Keywords: Favism, Glutathone, Neonates, G6PD

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Research Article: Original Paper |
Received: 2013/09/11 | Accepted: 2013/10/29 | Published: 2013/10/29 | ePublished: 2013/10/29