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Clinicopathological features and survival outcomes of pediatric mediastinal tumors: A 10-year retrospective study
Mahlagha Zahedi1 , Sahar Abbasinia2
1- Department of Pathology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Hematology and Oncology Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran , mahlaghazahedi@gmail.com
2- Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract:   (1636 Views)

Background: Primary mediastinal masses account for 3% of all chest tumors. Owing to their heterogeneous clinical presentations and the need for precise diagnosis, this study evaluated the clinicopathological features and survival outcomes of children with primary mediastinal masses admitted to Shahid Sadoughi Hospital, Yazd, Iran, between 2011 and 2021.
Methods: In this descriptive cross-sectional study, 17 children under 18 years of age with primary mediastinal masses were evaluated using census sampling. Data were collected with a checklist that included age, sex, tumor location, presenting symptoms, tumor type, treatment received, and malignancy status. Prognosis and survival were subsequently assessed. Statistical analysis was performed using SPSS 22, with Kaplan-Meier and Log-rank tests applied for survival assessment.
Results: Among the 17 patients, 12 (70.6%) were girls and 5 (29.4%) were boys. Five patients (29.4%) died during follow-up. Nine tumors (53%) were benign and eight (47%) were malignant. Ganglioneuroma was the most frequent tumor type (29.4%). Survival analysis showed no statistically significant association between survival and surgery (P=0.222), malignancy status (P=0.158), neural origin (P=0.666), chemotherapy (P=0.057), radiotherapy (P=0.752), tumor location (P=0.661), sex (P=0.670), or age (P=0.877).
Conclusion: The findings suggest that the distribution of histological types of primary mediastinal masses in children is influenced by anatomical location. However, age, sex, treatment type, and tumor location were not significantly associated with survival outcomes in this cohort.

Keywords: Survival Analysis, Iran, Pediatrics, Clinical Pathology, Histology, Mediastinal Tumors
Full-Text [PDF 330 kb]   (452 Downloads)    
Research Article: Research Article | Subject: Pathology
Received: 2025/04/18 | Accepted: 2025/10/28
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