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Lack of Association Between Dysnatremia and Hospitalization Length in Patients with COVID-19: Evidence from a Retrospective Analysis
Amirhossein Parmah1 , Ebrahim Kouhsari2 , Taraneh Esmaeili3 , Majid Dastorani4 , Saeid Amirkhanlou5
1- Department of Internal Medicine, Clinical Research Development Unit (CRDU), Shahid Sayad Shirazi Hospital, Golestan University of Medical Sciences, Gorgan, Iran.
2- Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
3- Department of Nephrology, Clinical Research Development Unit, Sayad Shirazi Hospital, Golestan University of Medical Sciences, Gorgan, Iran.
4- Metabolic Disorders Research Center, Golestan University of Medical Sciences, Golestan Province, Gorgan, Iran.
5- Department of Internal Medicine, Clinical Research Development Unit (CRDU), Shahid Sayad Shirazi Hospital, Golestan University of Medical Sciences, Gorgan, Iran. , ebrahim.msph@gmail.com
Abstract:   (1231 Views)
Background:  COVID-19 significantly affected global health, with research linking dysnatremia to increased ICU admission and mechanical ventilation in patients. Sodium abnormalities also complicate recovery, treatment, and hospitalization duration. This study further investigates the relationship between sodium abnormalities and hospitalization length in COVID-19 patients. Objectives: To evaluate the association between sodium abnormalities (hyponatremia and hypernatremia) and length of hospitalization in patients with COVID-19. Methods: A retrospective study was conducted on patients with PCR-confirmed COVID-19 between 2019 and 2021. Data collection involved reviewing medical records, laboratory findings, and conducting telephone interviews with patients. Results: The study comprised 129 participants, with a male-to-female ratio of 54.3% to 45.7%. Hyponatremia was present in 44.2% (n=57) of patients. Statistical analysis using the Spearman correlation coefficient and Kruskal-Wallis test revealed no significant relationship between serum sodium levels and length of hospitalization (P=0.789 and P=0.854, respectively). Conclusion: Despite previous reports of an association between sodium disorders and morbidity/mortality in COVID-19 patients, this study did not find a significant relationship between the two variables. Further research is warranted to explore the potential impact of sodium abnormalities on COVID-19 patient outcomes.
Keywords: COVID-19, electrolyte imbalances, dysnatremia, Length of hospital stay, morbidity
Full-Text [PDF 406 kb]   (279 Downloads)    
Research Article: Research Article | Subject: Laboratory Sciences
Received: 2025/02/26 | Accepted: 2025/08/27
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