Fri, May 22, 2026
Alaa Kazem1 
, Azad Reza Mansurian1 , Golam Reza Vaghari1 , Seyed Mostafa Mir1 , Fatemeh Mohammadzadeh2
, Azad Reza Mansurian1 , Golam Reza Vaghari1 , Seyed Mostafa Mir1 , Fatemeh Mohammadzadeh2
1- Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran
2- Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran ,msoheila66@yahoo.com
2- Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran ,
Abstract: (278 Views)
Background: Diabetic nephropathy is a major cause of kidney failure. The current study aimed to measure serum and urine albumin as well as other biochemical markers in individuals with type 2 diabetic nephropathy and to identify quick diagnostic approaches in these patients.
Method: The case-control study consisted of 40 patients with diabetic nephropathy and 40 diabetic patients without nephropathy. After assessing the biochemichal and clinical parameters, based on the ratio of random urine albumin to creatinine, patients were separated into two groups: patients with or without albuminuria. SPSS v18 software was used to analyze the results.
Results: In diabetic patients, the levels of urea, creatinine, uric acid were significantly higher in comparison to the control group and were 64.68±46.84, 2.01±1.82, 5.35±2.23 respectively. The average content of serum albumin in diabetic patients with nephropathy was notably lower compared to non-nephropathy patients (3.74±0.88. and 4.35±0.28) (p < 0.05). In diabetic nephropathy patients, urinary albumin had a direct relationship with serum creatinine level (r=0.347, p=0.028). In the control group, it was possible to check the status of serum albumin by measuring the level of creatinine (r = -0.305, p = 0.056), urea (r = -0.333, p = 0.036) and HbA1C (r = -0.376, p = 0.017).
Conclusion: The results revealed that high level of urinary albumin in patients with diabetic nephropathy has a direct association with the serum creatinine level, indicating a helpful index in the evaluation of nephropathy patients with albuminuria. However, further studies with a larger number of participants is required.
Method: The case-control study consisted of 40 patients with diabetic nephropathy and 40 diabetic patients without nephropathy. After assessing the biochemichal and clinical parameters, based on the ratio of random urine albumin to creatinine, patients were separated into two groups: patients with or without albuminuria. SPSS v18 software was used to analyze the results.
Results: In diabetic patients, the levels of urea, creatinine, uric acid were significantly higher in comparison to the control group and were 64.68±46.84, 2.01±1.82, 5.35±2.23 respectively. The average content of serum albumin in diabetic patients with nephropathy was notably lower compared to non-nephropathy patients (3.74±0.88. and 4.35±0.28) (p < 0.05). In diabetic nephropathy patients, urinary albumin had a direct relationship with serum creatinine level (r=0.347, p=0.028). In the control group, it was possible to check the status of serum albumin by measuring the level of creatinine (r = -0.305, p = 0.056), urea (r = -0.333, p = 0.036) and HbA1C (r = -0.376, p = 0.017).
Conclusion: The results revealed that high level of urinary albumin in patients with diabetic nephropathy has a direct association with the serum creatinine level, indicating a helpful index in the evaluation of nephropathy patients with albuminuria. However, further studies with a larger number of participants is required.
Research Article: Research Article |
Subject:
Biochemistry
Received: 2023/02/4 | Accepted: 2024/07/23
Received: 2023/02/4 | Accepted: 2024/07/23
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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