Volume 16, Issue 6 (Special issue (Nov-Dec) 2022)                   mljgoums 2022, 16(6): 8-12 | Back to browse issues page


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Suruthy A, Bijjaragi S, Neethu G V. Association of Acute Phase Reactants with COVID-19-related Severity and Mortality: A Study in a Tertiary Care Hospital in India. mljgoums 2022; 16 (6) :8-12
URL: http://mlj.goums.ac.ir/article-1-1530-en.html
1- Department of Pathology,J.J.M.Medical College,Davangere- Rajiv Gandhi University of Health and Sciences, Davangere, India
2- Department of Pathology,J.J.M.Medical College,Davangere- Rajiv Gandhi University of Health and Sciences, Davangere, India. , seemabijjaragi@gmail.com
3- Department of Pathology,J.J.M.Medical College,Davangere- Rajiv Gandhi University of Health and Sciences, Davangere, India.
Abstract:   (1418 Views)
Background and Objectives: The outbreak of coronavirus disease 2019 (COVID-19) has become a public health emergency. This study aimed to investigate a possible correlation between COVID-19 severity and mortality and serum levels of ferritin and C-reactive protein (CRP).
Methods: This retrospective descriptive study was conducted on 75 COVID-19 patients hospitalized in a tertiary care hospital in Central Karnataka (India) from April 2021 to June 2021. Demographic details as well as clinical and laboratory parameters were retrieved from hospital records.
Results: Of 75 patients, 50 were survivors and 25 were non-survivors. Serum ferritin levels were significantly associated with mortality (p<0.040). There was no significant association between CRP level and COVID-19 severity or mortality (p>0.05).
Conclusion: This study revealed that serum ferritin levels can be used as a prognostic marker for COVID-19 patients.
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Research Article: Research Article | Subject: Pathology
Received: 2022/06/15 | Accepted: 2022/11/6 | Published: 2022/11/28 | ePublished: 2022/11/28

References
1. Andrews MA, Areekal B, Rajesh KR, Krishnan J, Suryakala R, Krishnan B, et al. First confirmed case of COVID-19 infection in India: A case report. Indian J Med Res. 2020; 151(5): 490-492. [View at Publisher] [DOI:10.4103/ijmr.IJMR_2131_20] [PubMed] [Google Scholar]
2. Zheng J. SARS-CoV-2: an Emerging Coronavirus that Causes a Global Threat. Int J Biol Sci. 2020; 16(10): 1678-1685. [View at Publisher] [DOI:10.7150/ijbs.45053] [PubMed] [Google Scholar]
3. Liu J, Liu Y, Xiang P, Pu L, Xiong H, Li C, et al. Neutrophil-to-lymphocyte ratio predicts critical illness patients with 2019 coronavirus disease in the early stage. J Transl Med. 2020; 18(1): 206. [View at Publisher] [DOI:10.1186/s12967-020-02374-0] [PubMed] [Google Scholar]
4. Shekhanawar M, Sarala HT, Shaik RA. Serum Ferritin and C- Reactive Protein as Prognostic Factors in Patients with Novel Coronavirus 2019. Asian J Med Res. 2021; 10(2): 9-17. [View at Publisher]
5. Bozkurt FT, Tercan M, Patmano G, Bingol Tanrıverdi T, Demir HA, Yurekli UF. Can Ferritin Levels Predict the Severity of Illness in Patients With COVID-19? Cureus. 2021; 13(1): e12832. [View at Publisher] [DOI:10.7759/cureus.12832] [PubMed] [Google Scholar]
6. Richardson S, Hirsch JS, Narasimhan M, Crawford JM, McGinn T, Davidson KW, et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City Area. JAMA. 2020; 323(20): 2052-2059. . [View at Publisher] [DOI:10.1001/jama.2020.6775] [PubMed] [Google Scholar]
7. Chen T, Wu D, Chen H, Yan W, Yang D, Chen G, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ. 2020; 368: m1091. [View at Publisher] [DOI:10.1136/bmj.m1091] [Google Scholar]
8. Bennett TD, Hayward KN, Farris RW, Ringold S, Wallace CA, Brogan TV. Very high serum ferritin levels are associated with increased mortality and critical care in pediatric patients. Pediatr Crit Care Med. 2011;12(6):e233-e236236. [View at Publisher] [DOI:10.1097/PCC.0b013e31820abca8] [PubMed] [Google Scholar]
9. Liu Z, Sun R, Li J, Cheng W, Li L. Relations of anemia with the all-cause mortality and cardiovascular mortality in general population: a meta-analysis. Am J Med Sci. 2019; 358(3): 191-9. [View at Publisher] [DOI:10.1016/j.amjms.2019.05.016] [PubMed] [Google Scholar]
10. Kernan KF, Carcillo JA. Hyperferritinemia and infammation. Int Immunol. 2017; 29(9): 401-9. 13. [View at Publisher] [DOI:10.1093/intimm/dxx031] [PubMed]
11. Wessling-Resnick M. Crossing the iron gate: why and how transferrin receptors mediate viral entry. Annu Rev Nutr. 2018; 38: 431-58. [DOI:10.1146/annurev-nutr-082117-051749] [PubMed] [Google Scholar]
12. Rosario C, Zandman-Goddard G, Meyron-Holtz EG, D'Cruz DP, Shoenfeld Y. The Hyperferritinemic Syndrome: macrophage activation syndrome, Still's disease, septic shock and catastrophic antiphospholipid syndrome. BMC Medicine. 2013;11(1):185. [View at Publisher] [DOI:10.1186/1741-7015-11-185] [PubMed] [Google Scholar]
13. Harrison PM, Arosio P. The ferritins: molecular properties, iron storage function and cellular regulation. BiochimBiophys Acta. 1996; 1275(3): 161-20 7. [View at Publisher] [DOI:10.1016/0005-2728(96)00022-9] [PubMed] [Google Scholar]
14. Zhou F, Yu T, Du R, et al.: Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020; 395:1054-1062. [View at Publisher] [DOI:10.1016/S0140-6736(20)30566-3] [PubMed] [Google Scholar]
15. Taneri PE, Gomez-Ochoa SA, Llanaj E, Raguindin PF, Rojas LZ, Roa-Diaz ZM, et al: Anemia and iron metabolism in COVID-19: a systematic review and meta-analysis. Eur J Epidemiol. 2020; 35(8): 763-773. [View at Publisher] [DOI:10.1007/s10654-020-00678-5] [PubMed] [Google Scholar]
16. Murashima M, Nishimoto M, Kokubu M, Hamano T, Matsui M, Eriguchi M, et al. Inflammation as a predictor of acute kidney injury and mediator of higher mortality after acute kidney injury in non-cardiac surgery. Sci Rep. 2019; 9: 20260. [View at Publisher] [DOI:10.1038/s41598-019-56615-4] [PubMed] [Google Scholar]
17. Folsom AR, Lutsey PL, Astor BC, Cushman M. C-reactive protein and venous thromboembolism. A prospective investigation in the ARIC cohort. Thromb Haemost. 2009; 102: 615-619. [View at Publisher] [DOI:10.1160/TH09-04-0274] [PubMed] [Google Scholar]
18. Chen W, Zheng KI, Liu S, Yan Z, Xu C, Qiao Z. Plasma CRP level is positively associated with the severity of COVID-19. Ann Clin Microbiol Antimicrob. 2020; 19(1): 18. [View at Publisher] [DOI:10.1186/s12941-020-00362-2] [PubMed] [Google Scholar]

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