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mljgoums 2023, 17(5): 26-29 |
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Mirdar S, Khalili M, Aghaei Bahmanbeglou N. The effect of swimming and silymarin on placental growth factor in pregnant rats exposed to cadmium. mljgoums 2023; 17 (5) :26-29
URL: http://mlj.goums.ac.ir/article-1-1431-en.html
URL: http://mlj.goums.ac.ir/article-1-1431-en.html
1- Department of Sports Physiology, Faculty of Sports Sciences, Mazandaran University, Babolsar, Iran
2- Department of Sports Physiology, Islamic Azad University, Aliabad Katoul Branch, Islamic Azad University, Ali Abad Ktoul
3- Department of Physical Education and Sports Science, Ali Abad Ktoul Branch, Islamic Azad University, Ali Abad Ktoul
2- Department of Sports Physiology, Islamic Azad University, Aliabad Katoul Branch, Islamic Azad University, Ali Abad Ktoul
3- Department of Physical Education and Sports Science, Ali Abad Ktoul Branch, Islamic Azad University, Ali Abad Ktoul
Abstract: (462 Views)
Background: Exercise and dietary supplements can partially mitigate the negative effects of cadmium. The present study aimed to investigate the effect of swimming and silymarin on placental growth factor (PLGF) in pregnant mice exposed to cadmium.
Methods: Seventy-two 8-week-old pregnant Wistar rats (weighing 20 ± 200 g) were divided into 9 groups, with 8 rats in each group. Cadmium chloride at a dose of 400 mg/kg body weight was fed to rats by drinking a water solution. Silymarin (100 mg/kg body weight) was injected subcutaneously 3 times a week. The exercise program during pregnancy consisted of 60 minutes of swimming per day, conducted for 5 days a week. The microscopic sections of samples were taken 2 days after birth using the usual method of tissue sectioning. A 1-way analysis of variance (ANOVA) and Tukey post hoc test at the error level of 0.05 were used to analyze the data.
Results: The PLGF index in the cadmium group showed a significant decrease (P < 0.001) compared to the cadmium + silymarin and cadmium + silymarin and swimming groups. However, swimming training alone had no effect on PLGF index (P = 0.162).
Conclusion: Cadmium significantly reduced PLGF levels in neonatal lung tissue, and regular swimming endurance exercises and silymarin supplementation inhibited the effects of cadmium chloride.
Methods: Seventy-two 8-week-old pregnant Wistar rats (weighing 20 ± 200 g) were divided into 9 groups, with 8 rats in each group. Cadmium chloride at a dose of 400 mg/kg body weight was fed to rats by drinking a water solution. Silymarin (100 mg/kg body weight) was injected subcutaneously 3 times a week. The exercise program during pregnancy consisted of 60 minutes of swimming per day, conducted for 5 days a week. The microscopic sections of samples were taken 2 days after birth using the usual method of tissue sectioning. A 1-way analysis of variance (ANOVA) and Tukey post hoc test at the error level of 0.05 were used to analyze the data.
Results: The PLGF index in the cadmium group showed a significant decrease (P < 0.001) compared to the cadmium + silymarin and cadmium + silymarin and swimming groups. However, swimming training alone had no effect on PLGF index (P = 0.162).
Conclusion: Cadmium significantly reduced PLGF levels in neonatal lung tissue, and regular swimming endurance exercises and silymarin supplementation inhibited the effects of cadmium chloride.
Research Article: Original Paper |
Subject:
Sport Physiology
Received: 2021/09/19 | Accepted: 2022/08/3 | Published: 2024/01/15 | ePublished: 2024/01/15
Received: 2021/09/19 | Accepted: 2022/08/3 | Published: 2024/01/15 | ePublished: 2024/01/15
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