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Ahmadi A, Ghasemian M, Ayatollahi A A, Al-Khabori M, hosseini alarzi S S, Hojjati M T. Comparison of Hematologic and Biochemical Factors between Women with Gestational Diabetes and Healthy Pregnant Women. mljgoums 2021; 15 (5) :1-6
URL: http://mlj.goums.ac.ir/article-1-1386-en.html
Comparison of Hematologic and Biochemical Factors between Women with Gestational Diabetes and Healthy Pregnant Women
Alireza Ahmadi1 , Mahdi Ghasemian1 , Ali asghar Ayatollahi1 , Murtadha Al-Khabori2 , Seyedeh somayeh Hosseini alarzi3 , Mohammad taher Hojjati 4
1- Laboratory Science research center, faculty of Paramedicine of Golestan University of medical sciences
2- Hematology Department, COM&HS, Sultan Qaboos University, Muscat, Oman
3- Laboratory Science research center, faculty of Paramedicine of Golestan University of medical sciences, Gorgan, Iran
4- Laboratory Science research center, faculty of Paramedicine of Golestan University of medical sciences , mthhematology@gmail.com
Abstract:   (2740 Views) 
Background and objectives: Diagnosis glucose intolerance in pregnancy is very important in preventing maternal and fetal complications. In this study, we compared hematological and biochemical characteristics of healthy pregnant women and women with gestational diabetes mellitus (GDM) to find predisposing and prognostic variables of GDM.
Methods: In this study, 80 pregnant women (at 24-28 weeks of pregnancy) were divided into a GDM group and non-GDM group by performing oral glucose tolerance test using 75 g glucose according to the International Association of the Diabetes and Pregnancy Study Groups criteria.
Results: The mean age of women with GDM was significantly higher than those without GDM (p=0.048). Other variables including body mass index, gestational age and daily sleep duration did not differ significantly between the two groups (P>0.05). There was a significant association between family history of diabetes and incidence of GDM (p=0.040). In addition, the C-peptide level was significantly higher in pregnant women with GDM (p=0.004).
Conclusion: Considering the role of C-peptide in predicting metabolic syndrome, it is suggested to use this factor for identification of GDM patients.
Keywords: Gestational diabetes [MeSH], C-peptide [MeSH], c-reactive protein (CRP) [MeSH], Glucose Tolerance Test [MeSH]
Full-Text [PDF 608 kb]   (637 Downloads) |   |   Full-Text (HTML)  (1344 Views)  
Research Article: Research Article | Subject: Biochemistry
Received: 2021/05/2 | Accepted: 2021/08/1 | Published: 2021/08/31 | ePublished: 2021/08/31
References
1. Jang HC, Cho NH, Jung KB, Oh KS, Dooley SL, Metzger BE. Screening for gestational diabetes mellitus in Korea. Int J Gynaecol Obstet. 1995; 51: 115-22. [View at Publisher] [DOI] [PubMed] [Google Scholar]
2. Metzger BE, Coustan DR. Summary and recommendations of the Fourth International Workshop-Conference on Gestational Diabetes Mellitus. The Organizing Committee. Diabetes Care. 1998; 21 (Suppl 2): B161-7. [View at Publisher] [DOI] [Google Scholar]
3. Niyafar M, Salem A, Ali Asgharzadeh A. Risk factors for gestational diabetes and prevalence of impaired glucose tolerance six weeks after delivery. Med J Tabriz Uni Med Sciences Health Services. 2017; 39: 73-80. [Persian] [View at Publisher] [Google Scholar]
4. Hare JW. Diabetic complications of diabetic pregnancies. Semin Perinatol. 1994;18: 451-8. [PubMed] [Google Scholar]
5. Schmidt MI, Duncan BB, Reichelt AJ, Branchtein L, Matos MC, Costa e Forti A, et al. Gestational diabetes mellitus diagnosed with a 2-h 75-g oral glucose tolerance test and adverse pregnancy outcomes. Diabetes Care. 2001; 24(7): 1151-5. [View at Publisher] [DOI:10.2337/diacare.24.7.1151] [PubMed] [Google Scholar]
6. Pettitt DJ, Nelson RG, Saad MF, Bennett PH, Knowler WC. Diabetes and obesity in the offspring of Pima Indian women with diabetes during pregnancy. Diabetes Care 1993;16: 310-4. [View at Publisher] [DOI:10.2337/diacare.16.1.310] [PubMed] [Google Scholar]
7. Sacks DA, Greenspoon JS, Abu-Fadil S, Henry HM, Wolde-Tsadik G, Yao JF. Toward universal criteria for gestational diabetes: the 75-gram glucose tolerance test in pregnancy. Am J Obstet Gynecol 1995; 172: 607-14. [View at Publisher] [DOI:10.1016/0002-9378(95)90580-4] [PubMed] [Google Scholar]
8. Kyu Yeon Hur. New Diagnostic Criteria for Gestational Diabetes Mellitus and Pregnancy Outcomes in Korea. Diabetes Metab J. 2019; 43(6): 763-765. [DOI:10.4093/dmj.2019.0247] [PubMed] [Google Scholar]
9. Goli M, Firouzeh F. Prevalence of gestational diabetes and efficacy of risk factors in screening of referrals to health centers. J Holist Nurs Midwifery 2014; 24 :56-63.[Persian] [View at Publisher] [Google Scholar]
10. Yang X, Hsu-Hage B, Zhang H, Yu L, Dong L, Li J, Shao P, et al. Gestational diabetes mellitus in women of single gravidity in Tianjin City, China. Diabetes Care. 2002; 25: 847-51. [View at Publisher] [DOI:10.2337/diacare.25.5.847] [PubMed] [Google Scholar]
11. Kafkasli AC, Sertkaya AB, Selcuk E, Dogan K, Burak F, Yologlu S. Abnormal Glucose Challenge Test and Mild Gestational Diabetes. Gynaecologia et perinatologia. 2008; 17: 3-8. [View at Publisher] [Google Scholar]
12. Monteiro G, Subbalakshmi NK, Pai SR. A study on clinical characteristics of gestational diabetes mellitus associated with intrauterine fetal death. IJBR 2014; 5(1): [View at Publisher] [Google Scholar]
13. Vakili M, Rahimi Pardanjani S, Alipour N, Taheri M, Baeradeh N, Hashemi A. The prevalence of gestational diabetes and associated factors in pregnant women referred to health care centers of Yazd in 2012. J Sabzevar Univ Med Sci. 2015; 21(6): 1214-24. [Persian] [View at Publisher] [Google Scholar]
14. McCarthy AD, Curciarello R, Castiglione N, Tayeldín MF, Costa D, Arnol V, et al. Universal versus selective screening for the detection, control and prognosis of gestational diabetes mellitus in Argentina. Acta Diabetol. 2010; 47(2): 97-103. [View at Publisher] [DOI] [PubMed] [Google Scholar]
15. Maegawa Y, Sugiyama T, Kusaka H, Mitao M, Toyoda N. Screening tests for gestational diabetes in Japan in the 1st and 2nd trimester of pregnancy. Diabetes Res Clin Pract 2003;62:47-53. [View at Publisher] [DOI:10.1016/S0168-8227(03)00146-3] [PubMed] [Google Scholar]
16. Khatun N, Latif SA, Uddin MM. Risk factors for the development of gestationaldiabetes mellitus. Mymensingh Med J 2009;18(1 Suppl):S20-23. [PubMed] [Google Scholar]
17. Rodrigues S, Robinson E, Gray-Donald K. Prevalence of gestational diabetes mellitus among James Bay Cree women in northern Quebec. CMAJ. 1999; 4; 160: 1293-7. [View at Publisher] [PubMed] [Google Scholar]
18. Siribaddana SH, Deshabandu R, Rajapakse D, Silva K, Fernando DJ. The prevalence of gestational diabetes in a Sri Lankan antenatal clinic. Ceylon Med J. 1998;43(2):88-91. PubMed PMID: 9704548. [PubMed] [Google Scholar]
19. Kashi Z, Borzouei Sh, Akha O, Moslemizadeh N, Zakeri H, Mohammad Poor A, et al. Diagnostic Value of Fasting Plasma Glucose in Screening of Gestational Diabetes Mellitus. Int Endocrinol Metab. 2007; 5: 1-4. [persian] [View at Publisher] [Google Scholar]
20. Reutrakul S., Van Cauter E. Interactions between sleep, circadian function, and glucose metabolism: implications for risk and severity of diabetes. Ann. N. Y. Acad. Sci. 2014; 1311: 151-173. [View at Publisher] [DOI:10.1111/nyas.12355] [PubMed] [Google Scholar]
21. Myoga M, Tsuji M, Tanaka R, Shibata E, Askew DJ, Aiko Y, et al. Impact of sleep duration during pregnancy on the risk of gestational diabetes in the Japan environmental and Children's study (JECS). BMC Pregnancy Childbirth. 2019; 19(1): 483. [View at Publisher] [DOI:10.1186/s12884-019-2632-.] [PubMed] [Google Scholar]
22. Gooley JJ, Mohapatra L, Twan DCK. The role of sleep duration and sleep disordered breathing in gestational diabetes mellitus. Neurobiol Sleep Circadian Rhythms. 2017; 4: 34-43. [View at Publisher] [DOI:10.1016/j.nbscr.2017.11.001] [PubMed] [Google Scholar]
23. Jahanpak N, Razmjoo N, Rezaei Ardani A, Mazloum S, Bonakdaran S. The Relationship between Sleep Duration and Glucose Challenge Test Results in Pregnant Women without Risk Factors of Diabetes. The Iranian Journal of Obstetrics, Gynecology and Infertility, 2013; 16(60): 9-17. [View at Publisher] [DOI] [Google Scholar]
24. Cai S, Tan S, Gluckman PD, Godfrey KM, Saw SM, Teoh OH, et al. GUSTO study group. Sleep Quality and Nocturnal Sleep Duration in Pregnancy and Risk of Gestational Diabetes Mellitus. Sleep. 2017; 40(2). [View at Publisher] [DOI:10.1093/sleep/zsw058] [PubMed] [Google Scholar]
25. O'Keeffe M, St-Onge MP. Sleep duration and disorders in pregnancy: implications for glucose metabolism and pregnancy outcomes. Int J Obes (Lond). 2013;37(6):765-770. doi:10.1038/ijo.2012.142. [View at Publisher] [DOI:10.1038/ijo.2012.142] [PubMed] [Google Scholar]
26. Jones AG, Hattersley AT. The clinical utility of C-peptide measurement in the care of patients with diabetes. Diabet Med. 2013; 30(7):803-17. [View at Publisher] [DOI:10.1111/dme.12159] [PubMed] [Google Scholar]
27. Yin P, Shao P, Liu H, et al. C-peptide levels and the risk of diabetes and pre-diabetes among Chinese women with gestational diabetes. J Diabetes Complications. 2017; 31(12):1658-1662. [View at Publisher] [DOI:10.1016/j.jdiacomp.2017.08.006] [PubMed] [Google Scholar]
28. Homko C, Sivan E, Chen X, Reece EA, Boden G. Insulin secretion during and after pregnancy in patients with gestational diabetes mellitus. J Clin Endocrinol Metab. 2001; 86(2): 568-73. [View at Publisher] [DOI:10.1210/jcem.86.2.7137] [PubMed] [Google Scholar]
29. Fatema N, Deeba F, Akter S, Sultana N, Nasrin B, Ali L, et al. CRP(C-reactive protein) in Early Pregnancy Predictor for Development of GDM. Mymensingh Med J. 2016; 25: 271-6. [PubMed] [Google Scholar]
30. Wang Y, Tan M, Huang Z, Sheng L, Ge Y, Zhang H, et al. Elemental contents in serum of pregnant women with gestational diabetes mellitus. Biol Trace Elem Res 2002;88:113-8. [View at Publisher] [DOI:10.1385/BTER:88:2:113] [PubMed] [Google Scholar]
31. Bo S, Lezo A, Menato G, Gallo ML, Bardelli C, Signorile A, et al. Gestational hyperglycemia, zinc, selenium, and antioxidant vitamins. Nutrition. 2005; 21(2): 186-91. [View at Publisher] [DOI:10.1016/j.nut.2004.05.022] [Google Scholar]
32. Ugwuja E, Akubugwo EI, Ejikeme B. Plasma Copper and Zinc in Pregnancy Complicated with Diabetes Mellitus. Pakistan Journal of Nutrition. 2010; 9: 861-864. [DOI:10.3923/pjn.2010.861.864] [Google Scholar]
33. Qiu C, Sorensen TK, Luthy DA, Williams MA. A prospective study of maternal serum C-reactive protein (CRP) concentrations and risk of gestational diabetes mellitus. Paediatr Perinat Epidemiol. 2004 Sep;18(5):377-84. [View at Publisher] [DOI:10.1111/j.1365-3016.2004.00578.x] [PubMed] [Google Scholar]
34. D'Anna R, Baviera G, De Vivo A, Facciolà G, Di Benedetto A, Corrado F.C-reactive protein as an early predictor of gestational diabetes mellitus. J Reprod Med. 2006; 51(1): 55-8. [PubMed] [Google Scholar]
35. Wolf M, Sandler L, Hsu K, Vossen-Smirnakis K, Ecker JL, Thadhani R.First-trimester C-reactive protein and subsequent gestational diabetes. Diabetes Care 2003 Mar;26:819-24. [View at Publisher] [DOI:10.2337/diacare.26.3.819] [PubMed] [Google Scholar]
36. Leipold H, Worda C, Gruber CJ, Prikoszovich T, Wagner O, Kautzky-Willer A.Gestational diabetes mellitus is associated with increased C-reactive protein concentrations in the third but not second trimester. Eur J Clin Invest 2005;35:752-7. [View at Publisher] [DOI:10.1111/j.1365-2362.2005.01574.x] [PubMed] [Google Scholar]
37. Ahari U. Z, Falsafi P, Pouralibaba F, Eslami H, Maleki S, Pakdel F, Rahbar M. Comparison of Salivary Alpha Amylase and Peroxidase Levels in Women with GDM and Non-Diabetic Pregnant Women. Biomed Pharmacol J. 2016; 9(2). [View at Publisher] [DOI:10.13005/bpj/964] [Google Scholar]
38. Khosrowbeygi A, Shiamizadeh N, Taghizadeh N. Maternal circulating levels of some metabolic syndrome biomarkers in gestational diabetes mellitus. Endocrine. 2016 Feb;51(2):245-55. [DOI:10.1007/s12020-015-0697-4] [PubMed] [Google Scholar]
39. Ruoheng Zheng, Juanwen Zhang, Zhao Ying, Nengneng Zheng. Low Serum Amylase is Associated with Gestational Diabetes Mellitus in Chinese Pregnant Women. . 2015;61(10):1423-8. [DOI:10.7754/Clin.Lab.2015.150129] [PubMed] [Google Scholar]
40. Yu F, Zhou W, Tan X, Jiang Y. Gestational Diabetes Mellitus is Associated with Plasma Amylase in a Chinese Pregnant Women Population. Clin Lab. 2019 Jan 1;65(1). [View at Publisher] [DOI:10.7754/Clin.Lab.2018.180550] [PubMed] [Google Scholar]
41. Stephansson O, Dickman PW, Johansson A, Cnattingius S. Maternal hemoglobin concentration during pregnancy and risk of stillbirth. JAMA. 2000; 284(20): 2611-7. [View at Publisher] [DOI] [PubMed] [Google Scholar]
42. Zafari M, Aghamohammady A, Tofighi M, Tahmasebi H. The Relationship between Maternal HemoglobinConcen Tretion and Gestational Diabetes Melitus. International Journal of Nursing Science. 2011; 1: 9-11. [View at Publisher] [DOI:10.5923/j.nursing.20110101.02]
43. Lao TT, Chan LY, Tam KF, Ho LF. Maternal hemoglobin and risk of gestational diabetes mellitus in Chinese women. Obstet Gynecol. 2002; 99: 807-12. [View at Publisher] [DOI:10.1016/S0029-7844(02)01941-5] [PubMed] [Google Scholar]
44. Helin A, Kinnunen TI, Raitanen J, Ahonen S, Virtanen SM, Luoto R. Iron intake,haemoglobin and risk of gestational diabetes: a prospective cohort study. BMJ Open. 2012; 2. pii: e001730. [DOI:10.1136/bmjopen-2012-001730] [PubMed] [Google Scholar]
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