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mljgoums 2020, 14(3): 33-39 |
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Abdullahi I N, Adekola H A, Emeribe A U, Ahmad A E, Yunusa T, Zakari M M, et al . Association of Hemoglobin Electrophoretic Phenotype with Human Parvovirus B19 infection among Pregnant Women attending Abuja Tertiary Hospital, Nigeria. mljgoums 2020; 14 (3) :33-39
URL: http://mlj.goums.ac.ir/article-1-1290-en.html
URL: http://mlj.goums.ac.ir/article-1-1290-en.html
Idris Nasir Abdullahi 
1, Hafeez Aderinsayo Adekola2 , Anthony Uchenna Emeribe3 , Abdurrahman Elfulaty Ahmad4 , Thairu Yunusa5 , Maryam Muhammad Zakari6 , Nkechi Blessing Onukegbe7 , Sanusi Musa4 , Dele Ohinoyi Amadu8 , Bamidele Soji Oderinde9
1, Hafeez Aderinsayo Adekola2 , Anthony Uchenna Emeribe3 , Abdurrahman Elfulaty Ahmad4 , Thairu Yunusa5 , Maryam Muhammad Zakari6 , Nkechi Blessing Onukegbe7 , Sanusi Musa4 , Dele Ohinoyi Amadu8 , Bamidele Soji Oderinde9
1- Department of Medical Laboratory Science, Ahmadu Bello University Zaria Nigeria , eedris888@yahoo.com
2- Department of Microbiology, Olabisi Onabanjo University, Ogun state, Nigeria
3- Department of Medical Laboratory Science, University of Calabar, Calabar, Nigeria
4- Department of Medical Laboratory Science, Ahmadu Bello University Zaria Nigeria
5- Department of Medical Microbiology and Parasitology, University of Abuja, Abuja, Nigeria
6- Department of Obstetrics and Gyaenacology, University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria
7- Department of Strategic Information and Research, Institute of Human Virology, Abuja, Nigeria
8- Department of Medical Microbiology and Parasitology, University of Ilorin Teaching Hospital, Ilorin, Nigeria
9- Department of Medical Laboratory Science, University of Maiduguri, Maiduguri, Nigeria
2- Department of Microbiology, Olabisi Onabanjo University, Ogun state, Nigeria
3- Department of Medical Laboratory Science, University of Calabar, Calabar, Nigeria
4- Department of Medical Laboratory Science, Ahmadu Bello University Zaria Nigeria
5- Department of Medical Microbiology and Parasitology, University of Abuja, Abuja, Nigeria
6- Department of Obstetrics and Gyaenacology, University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria
7- Department of Strategic Information and Research, Institute of Human Virology, Abuja, Nigeria
8- Department of Medical Microbiology and Parasitology, University of Ilorin Teaching Hospital, Ilorin, Nigeria
9- Department of Medical Laboratory Science, University of Maiduguri, Maiduguri, Nigeria
Abstract: (6912 Views)
Background and Objectives: Human parvovirus B19 (B19V) is a widespread virus with various manifestations depending on the immunologic and hematologic status of the host. Infection with the virus can cause a wide range of complications in fetus of infected pregnant women, especially those with hemoglobinopathies. This study aimed to determine association of hemoglobin electrophoretic patterns and risk of B19V infection in pregnant women.
Methods: Blood samples were collected from 200 pregnant women attending University of Abuja Teaching Hospital, Abuja, Nigeria. The samples were screened for anti-B19V IgM and IgG. Hemoglobin patterns were determined using commercial enzyme-linked immunosorbent assay kits and Minicap Flex Piercing Electrophoresis system. Structured questionnaires were used to collate sociodemographic variables and associated risk factors of B19V.
Results: Of 200 participants, 12 (6.0%) were positive for B19V IgM, 45 (22.5%) were positive for IgG and two (1.0%) were positive for both antibody, while 145 (72.5%) had no detectable B19V antibody. Twenty-six subjects (28.3%) with HbAA hemoglobin pattern had B19V IgG of whom, nine (12.5%) had HbAS and 11 (30.6%) had HbSS electrophoretic patterns. There was a significant association between prevalence of anti-B19V IgG and hemoglobin electrophoretic pattern of participants (P=0.037). However, no association was found between prevalence of B19V IgM and hemoglobin electrophoretic pattern, age and parity of pregnant women (P>0.05).
Conclusion: Our findings revealed a high prevalence of B19V infection among pregnant women in the studied area. In addition, acute B19V seems to be associated with hemoglobin electrophoretic patterns of pregnant women. It is recommended to follow up newborns of anti-B19V IgM positive pregnant women.
Methods: Blood samples were collected from 200 pregnant women attending University of Abuja Teaching Hospital, Abuja, Nigeria. The samples were screened for anti-B19V IgM and IgG. Hemoglobin patterns were determined using commercial enzyme-linked immunosorbent assay kits and Minicap Flex Piercing Electrophoresis system. Structured questionnaires were used to collate sociodemographic variables and associated risk factors of B19V.
Results: Of 200 participants, 12 (6.0%) were positive for B19V IgM, 45 (22.5%) were positive for IgG and two (1.0%) were positive for both antibody, while 145 (72.5%) had no detectable B19V antibody. Twenty-six subjects (28.3%) with HbAA hemoglobin pattern had B19V IgG of whom, nine (12.5%) had HbAS and 11 (30.6%) had HbSS electrophoretic patterns. There was a significant association between prevalence of anti-B19V IgG and hemoglobin electrophoretic pattern of participants (P=0.037). However, no association was found between prevalence of B19V IgM and hemoglobin electrophoretic pattern, age and parity of pregnant women (P>0.05).
Conclusion: Our findings revealed a high prevalence of B19V infection among pregnant women in the studied area. In addition, acute B19V seems to be associated with hemoglobin electrophoretic patterns of pregnant women. It is recommended to follow up newborns of anti-B19V IgM positive pregnant women.
Research Article: Original Paper |
Subject:
Virology
Received: 2020/04/17 | Accepted: 2020/04/30 | Published: 2020/04/30 | ePublished: 2020/04/30
Received: 2020/04/17 | Accepted: 2020/04/30 | Published: 2020/04/30 | ePublished: 2020/04/30
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