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Soosaraei M, Daryani A, Sarvi S, Rahimi M T, Fakhar M, Ziaei Hezarjaribi H et al . Activity of Iranian Medicinal Herbs against Human Intestinal Parasites (HIP): A Systematic Review. mljgoums 2020; 14 (5) :1-12
URL: http://mlj.goums.ac.ir/article-1-1249-en.html
URL: http://mlj.goums.ac.ir/article-1-1249-en.html
Masoud Soosaraei1 
, Ahmad Daryani1 , Shahabeddin Sarvi1 , Mohamad Taghi Rahimi2 , Mahdi Fakhar1 , Hajar Ziaei Hezarjaribi1 , Mehdi Sharif 3
, Ahmad Daryani1 , Shahabeddin Sarvi1 , Mohamad Taghi Rahimi2 , Mahdi Fakhar1 , Hajar Ziaei Hezarjaribi1 , Mehdi Sharif 3
1- Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari,Iran
2- School of Medical Science, Shahroud University of Medical Sciences, Shahroud, Iran
3- Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari,Iran ,msharifmathdsi@yahoo.com
2- School of Medical Science, Shahroud University of Medical Sciences, Shahroud, Iran
3- Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari,Iran ,
Abstract: (3709 Views)
Background and objectives: Intestinal parasitic infections are a major public health problem worldwide, especially in developing countries. It is estimated that around 3.5 billion people are infected with intestinal parasites. Human intestinal parasites (HIP) are clinically important due to broad epidemiological distribution, reinfection and drug resistance. In the last decades, bioactive compounds from herbs were used against a wide variety of microorganisms including parasites. We aimed to perform a systematic review on studies on the effects of medicinal herbs on HIPs in Iran.
Methods: Relevant scientific publications until April, 2015 were extracted from five English databases (PubMed, Google Scholar, Ebsco, Science Direct and Scopus) and four Persian databases (Magiran, Irandoc, IranMedex and the Scientific Information Database).
Results: A total of 18 papers and two dissertations met the inclusion criteria. Overall, 22 different plant extracts were used against Giardia lamblia, Entamoeba histolytica, Cryptosporidium and Hymenolepis nana. Based on the results, the extracts could exert time- and dose-dependent inhibitory effects against the tested HIPs. Five plants types including Allium, Chenopodium botrys, Carum copticum, F. asafoetida and Artemisia annua were able to completely inhibit the tested parasites, while Thymus vulgaris and A. paradoxum showed the lowest inhibitory effect (7%).
Conclusions: Given the findings, it is recommended to conduct in vivo studies on medicinal herbs with favorable in vitro effects against HIPs.
Methods: Relevant scientific publications until April, 2015 were extracted from five English databases (PubMed, Google Scholar, Ebsco, Science Direct and Scopus) and four Persian databases (Magiran, Irandoc, IranMedex and the Scientific Information Database).
Results: A total of 18 papers and two dissertations met the inclusion criteria. Overall, 22 different plant extracts were used against Giardia lamblia, Entamoeba histolytica, Cryptosporidium and Hymenolepis nana. Based on the results, the extracts could exert time- and dose-dependent inhibitory effects against the tested HIPs. Five plants types including Allium, Chenopodium botrys, Carum copticum, F. asafoetida and Artemisia annua were able to completely inhibit the tested parasites, while Thymus vulgaris and A. paradoxum showed the lowest inhibitory effect (7%).
Conclusions: Given the findings, it is recommended to conduct in vivo studies on medicinal herbs with favorable in vitro effects against HIPs.
Research Article: Review Article |
Subject:
Parasitology
Received: 2019/09/9 | Accepted: 2020/05/3 | Published: 2020/08/24 | ePublished: 2020/08/24
Received: 2019/09/9 | Accepted: 2020/05/3 | Published: 2020/08/24 | ePublished: 2020/08/24
References
1. Handzel T, Karanja DM, Addiss DG, Hightower AW, Rosen DH, Colley DG. Geographic distribution of schistosomiasis and soil-transmitted helminths in Western Kenya: implications for anthelminthic mass treatment. American JTrop Med Hyg. 2003; 69(3): 318-23. [DOI:10.4269/ajtmh.2003.69.318] [PubMed] [Google Scholar]
2. Sayyari A, Imanzadeh F, Bagheri Yazdi S, Karami H, Yaghoobi M. Prevalence of intestinal parasitic infections in the Islamic Republic of Iran. East Mediterr Health J. 2005; 11(3): 377-83. [PubMed] [Google Scholar]
3. Garcia LS. Diagnostic medical parasitology. 5th ed. ASM Press. 2007. [DOI:10.1128/9781555816018] [Google Scholar]
4. World Health O. Cancer pain relief: with a guide to opioid availability. 2nd ed. WHO 1996. [Google Scholar]
5. Francis E, Cox G, Julius P, Wakelin KD. Parasitology.2nd ed. WB Saunder. 1999; 5:18-30.
6. Okyay P, Ertug S, Gultekin B, Onen O, Beser E. Intestinal parasites prevalence and related factors in school children, a western city sample-Turkey. BMC pub health. 2004; 4(1): 64-8. [DOI:10.1186/1471-2458-4-64] [PubMed] [Google Scholar]
7. Montresor A, Crompton DWT, Hall A, Bundy DAP, Savioli L. Guidelines for the evaluation of soil-transmitted helminthiasis and schistosomiasis at community level. WHO. 1998:1-49. [Google Scholar]
8. Pink R, Hudson A, Mouriès MA, Bendig M. Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005; 4(9): 727-40. [DOI:10.1038/nrd1824] [PubMed] [Google Scholar]
9. Müller J, Hemphill A, Müller N. Treatment of Giardiasis and Drug Resistance. vitro Springer. 2011; 10(4): 10-21. [Google Scholar]
10. Gautam RK, Dixit PK, Mittal S. Herbal Sources of Antidepressant Potential: A Review. Int J Pharm Sci Rev Res. 2013; 18 (1): 86-91. [Google Scholar]
11. Shabani M. Effect of the Garlic drug on Giardia disease and effect of praziquantle on Himnolepis nana in Neka city. Pharmacy thesis in Tehran Univ Med Sci. 1998.
12. Saiedi A. Evaluation of some essences from medicinal plants on Giardia lamblia and Entamoeba histolytica cysts as in vitro. Pharmacy thesis. Shiraz Uni Med Sci. 1999.
13. Bahri Najafi R, Motazedian M, Azadbakht M, Sodagar R: Effect of essential oils from some medicinal plants on Giardia lamblia cyst in comparison with metronidazol. Esfehan Uni Res J. 2003; 17(2): 199-206.
14. Azadbakht M, Sajadi S, Rostami J. Giardiacidal Activity Of The Express Obtained From Bulbs Of Three Allium Species On Giardia Intestinalis Cysts. Iran J Basic Med Sci. 2003; 3(6):184-188. [Google Scholar]
15. Azadbakht M, Yousefi Z, Shaaban KB, Ziaee H, Mehralian A. Evaluation Of Chubak Aqueous Extract In Parasite Decontamination On Vegetables And Comparison With Commercial Detergent In Sari. J Med Pla. 2005 ;3(9):51-58. [Google Scholar]
16. Safar Harandi MM, Ghaffarifar F. In vitro and in vivo effects of garlic (Allium sativum) extract on Giardia lamblia and Giardia muris. Hakim Res J. 2006; 3(9): 58-64. [Google Scholar]
17. Sadjjadi SM, Rostami J, Azadbakht M. Giardiacidal activity of lemon juice, vinifer and vinegar on Giardia intestinalis cysts. Southeast Asian j trop med pub health. 2006; 37(3): 24- 27. [PubMed] [Google Scholar]
18. Behnia M, Haghighi A, Komeilizadeh H, Tabaei SJS, Abadi A. In vitro antiamoebic activity of Iranian Allium sativum in comparison with metronidazole against Entamoeba histolytica. Iranian J Parasitol. 2008; 3(4): 32-8. [Google Scholar]
19. Shahabi S, Ayazi Roozbehani F, Kamalinejad M, Abadi A. Anti-giardia activity of Carum copticum on Giardia lamblia cysts in vitro. Pejouhesh. 2008; 32(4): 303-307.
20. Mehrabi M, Sadraei J, Ghafarifar F. The effects of garlic on the oocyst of cryptosporidium parvum in HANK medium. J Kordestan Uni Med Sci. 2011; 17(2): 53-60.
21. Rahimi-Esboei B, Gholami S, Azadbakht M, Ziaei H. Effect of Hydroalcholic extract of Artemisia annua on cysts of Giardia lamblia in vitro. J Mazand Uni Med Sci. 2012; 22(90): 72-80. [Google Scholar]
22. Safarnejad Tameshkel F, Khatami Nejad M, Nasrollahi A, Rahdari P, Gholam Hossein Poor F, Rahnavard A. The antimicrobial effect of methanol extracts of Eucalyptus, Satureia Hortensis and Heracleum Glabrescens on Giardia Cysts. Med Lab J. 2012; 6(2): 21-27. [Google Scholar]
23. Rezaiemanesh M, Shirbazou S. In-vitro giardicidal effect of aqueous and alcoholic extracts of Asafoetida on Giardia lamblia cyst. J Birjand Uni Med Sci. 2012; 19(1): 22-23 [Google Scholar]
24. Rahimi-Esboei B, Ebrahimzadeh M, Gholami S, Falah-Omrani V. Anti-giardial activity of Sambucus ebulus. Eur Rev Med Pharmacol Sci. 2013; 17(15): 2047-50. [PubMed] [Google Scholar]
25. Rezaeemanesh M, Shirbazoo S, Pouryaghoub N. In-Vitro Giardicidal Effects of Aqueous and Alcoholic Extracts of Chenopodium Botrys L. on Giardia Lamblia Cysts. J Torbat Heydariyeh Uni Med Sci. 2013; 1(1): 21-31. [Google Scholar]
26. Gholami S, Azadbakht M, Ziaei Hezarjaribi H, Rahimi-Esboei B. Anti-Giardial Activity of Chloroformic Extract of Tanacetum parthenium and Artemisia annua in vitro.
Res Molecul Med. 2014; 2(1): 45-50. [Google Scholar]
27. Rahimi-Esboei B, Ghorbani A, Gholami S, Azadbakht M, Ziaei H, Taghavi M. Antiparasitic effects of Allium paradoxum as a conventional consumed vegetable. African Jo Microbiol Res. 2014; 8(31): 2979- 83. [DOI:10.5897/AJMR2013.6402] [Google Scholar]
28. Fallahi S, Rostami A, Delfan B, Pournia Y, Rashidipour M. Effect of olive leaf, Satureja khuzestanica, and Allium sativum extracts on Giardia lamblia cysts compared with metronidazole in vitro. J Parasit Dis J. 2015; 8(1): 1-6. [PubMed] [Google Scholar]
29. Elmi T, Gholami SH, Azadbakht M, Rahimi-Esboei B, Geraili Z. The effects of hydroalcoholic extract of leaves and onion of Allium paradoxum on Giardia lamblia in mice. J Shahrekord Uni Med Sci. 2014; 16(1): 13-22. [Google Scholar]
30. Elmi T, Gholami S, Azadbakht M, Ziaei H, Sari I. Effect of Chloroformic Extract of Tanacetum parthenium in the treatment of Giardia lamblia infection in Balb/c Mice. J Mazandaran Uni Med Sci. 2014; 24(1): 157-165. [Google Scholar]
31. Abasian L, Bazyar A, Shirbazo S, Sayehmiri K, Ahmad N. Prevalence of Giardia lamblia in Iran: a systematic review and Meta analysis study. Pejouhesh. 2013; 36(5): 111-6. [Google Scholar]
32. Wright JM, Dunn LA, Upcroft P, Upcroft JA. Efficacy of antigiardial drugs. Exp opin drug Saf. 2003; 2(6): 529-41. [DOI:10.1517/14740338.2.6.529] [PubMed] [Google Scholar]
33. Modarres R, Silva VDPR. Rainfall trends in arid and semi-arid regions of Iran. JArid Enviro. 2007; 70(2): 344-55. [DOI:10.1016/j.jaridenv.2006.12.024] [Google Scholar]
34. Shahabi S. Epidemiologic study of intestinal parasites among elementary school children in Shahr-Yar. Research Med. 2001; 24: 133-9.
35. Firoozabadi A, Azizi M. Prevalence of intestinal parasitic infections among fast-food restaurant workers in Yazd. J Shahid Sadoghi Uni med Sci. 2003; 1(11): 29-33. [Google Scholar]
36. Albonjco M, Stoltzfus R, Savioli L, Tielsch J, Chwaya H, Ercole E. Epidemiological evidence for a differential effect of hookworm species, Ancylostoma duodenale or Necator americanus, on iron status of children. Int J Epidemiol. 1998; 27(3): 530-7. [DOI:10.1093/ije/27.3.530] [PubMed] [Google Scholar]
37. Mahyar A, Daneshi kohan M, Saghafi H, Rezaie M. Intestinal parasitic infections among disabled children in Qazvin. J Qazvin Uni med Sci. 2000; 4(2): 64-70. [Google Scholar]
38. Arbabi M, Talari S. Intestinal parasites prevalence in students of Kashan university of medical sciences. J Ilam Uni Med Sci. 2004; 12(3): 44-5. [Google Scholar]
39. Eja ME, Asikong BE, Abriba C, Arikpo GE, Anwan EE, Enyi-Idoh KH. A comparative assessment of the antimicrobial effects of garlic (Allium sativum) and antibiotics on diarrheagenic organisms. Southeast Asian J Trop Med Pub Health. 2007; 38(2): 343-8. [PubMed] [Google Scholar]
40. Abdel-Salam AM, Ammar N, Abdel-Hamid AZ. Effectiveness of probiotic Labneh supplemented with garlic or onion oil against Schistosoma mansoni in infected mice. Int J Dairy Sci. 2008; 3(2): 97-104. [DOI:10.3923/ijds.2008.97.104] [Google Scholar]
41. Moazeni M, Nazer A. In vitro effectiveness of garlic (Allium sativum) extract on scolices of hydatid cyst. World J Surg. 2010; 34(11): 2677-81. [DOI:10.1007/s00268-010-0718-7] [PubMed] [Google Scholar]
42. Soffar SA, Mokhtar GM. Evaluation of the antiparasitic effect of aqueous garlic (Allium sativum) extract in hymenolepiasis nana and giardiasis. J Egypt Soc Parasitol. 1991; 21(2): 497-502. [PubMed] [Google Scholar]
43. Harris JC, Plummer S, Turner MP, Lloyd D. The microaerophilic flagellate Giardia intestinalis: Allium sativum (garlic) is an effective antigiardial. Microbiol. 2000; 146(12): 3119-27. [DOI:10.1099/00221287-146-12-3119] [PubMed] [Google Scholar]
44. Martin KW, Ernst E. Herbal medicines for treatment of bacterial infections: a review of controlled clinical trials. J Antimicrob Chemother. 2003; 51(2): 241-6. [DOI:10.1093/jac/dkg087] [PubMed] [Google Scholar]
45. Milner JA. Garlic: its anticarcinogenic and antitumorigenic properties. Nutr Rev. 1996; 54(11): 82-6. [DOI:10.1111/j.1753-4887.1996.tb03823.x] [PubMed] [Google Scholar]
46. Meng Y, Lu D, Guo N, Zhang L, Zhou G. Anti-HCMV effect of garlic components. Virol Sin. 1993; 8: 147-50.
47. Cai Y. Anticryptococcal and antiviral properties of garlic. Cardiol Pract. 1991; 9: 11. [Google Scholar]
48. Lawson L, Wang Z. Pre-hepatic fate of the organosulfur compounds derived from garlic (Allium sativum). Planta Med. 1993; 59(7); 688-9. [DOI:10.1055/s-2006-959976] [Google Scholar]
49. Ankri S, Mirelman D. Antimicrobial properties of allicin from garlic. Microb infect. 1999; 1(2): 125-9. [DOI:10.1016/S1286-4579(99)80003-3] [PubMed] [Google Scholar]
50. Appleton JA, Tansey MR. Inhibition of growth of zoopathogenic fungi by garlic extract. Mycolog. 1975: 67(4): 882-5. [DOI:10.1080/00275514.1975.12019817] [PubMed] [Google Scholar]
51. Bilia AR, Lazari D, Messori L, Taglioli V, Temperini C, Vincieri FF. Simple and rapid physico-chemical methods to examine action of antimalarial drugs with hemin: its application to Artemisia annua constituents. Life Sci. 2002; 70(7): 769-78. [DOI:10.1016/S0024-3205(01)01447-3] [PubMed] [Google Scholar]
52. Fidock DA, Rosenthal PJ, Croft SL, Brun R, Nwaka S. Antimalarial drug discovery: efficacy models for compound screening. Nature Rev Drug Discov. 2004; 3(6): 509-520. [DOI:10.1038/nrd1416] [PubMed] [Google Scholar]
53. Rowen RJ. Artemisinin: from malaria to cancer treatment. Townsend Letter for Doctors and Patient. 2002: 233(12): 86-9. [Google Scholar]
54. Lai H, Sasaki T, Singh NP, Messay A. Effects of artemisinin-tagged holotransferrin on cancer cells. Life Sci. 2005; 76(11): 1267-79. [DOI:10.1016/j.lfs.2004.08.020] [PubMed] [Google Scholar]
55. Saddi M, Sanna A, Cottiglia F, Chisu L, Casu L, Bonsignore L. Antiherpes virus activity of Artemisia arborescens essential oil and inhibition of lateral diffusion in Vero cells. Ann Clin Microbiol Antimicrob. 2007; 6(1): 10-17. [DOI:10.1186/1476-0711-6-10] [PubMed] [Google Scholar]
56. Chen YT, Ma L, Mei Q, Tang Y, Liao XG. An experimental trial of artemether in treatment of Pneumocystis carinii in immunosuppressed rats. Chinese med J. 1994; 107(9): 673-677. [PubMed] [Google Scholar]
57. Dharmananda S. QING-HAO and the Artemisias Used in Chinese Medicine. 2002: 33.
58. Ridley RG, Hudson N. Oxidative stress and antimalarial drugs. Curr Biol. 1998; 8: 346-9.
59. Ramadan NI, Abdel-Aaty HE, Abdel-Hameed DM, El Deeb HK, Samir NA, Mansy SS. Effect of Ferula assafoetida on experimental murine Schistosoma mansoni infection. J Egypt Soc Parasitol. 2004; 34(3): 1077-94. [PubMed] [Google Scholar]
60. Ramadan NI, Al Khadrawy FM. The in vitro effect of Assafoetida on Trichomonas vaginalis. J Egypt Soc Parasitol. 2003; 33(2): 615-30. [PubMed] [Google Scholar]
61. Iranshahy M, Iranshahi M. Traditional uses, phytochemistry and pharmacology of asafoetida (Ferula assa-foetida oleo-gum-resin) A review. J Ethnopharmacol. 2011; 134(1): 1-10. [DOI:10.1016/j.jep.2010.11.067]
62. El Deeb HK, Al Khadrawy FM, El-Hameid AKA. Inhibitory effect of Ferula asafoetida L.(Umbelliferae) on Blastocystis sp. subtype 3 growth in vitro. Parasitol Res. 2012; 111(3): 1213-21. [DOI:10.1007/s00436-012-2955-1]
63. Gadano A, Gurni A, Nigro López M, López P, Gratti A, van Baren C. Cytogenetic effects of aqueous extracts of the medicinal plant Paico (Chenopodium multifidum L.). Pharm Biol. 2000; 38(1): 7-12. [DOI:10.1076/1388-0209(200001)3811-BFT007]
64. Kliks MM. Studies on the traditional herbal anthelmintic Chenopodium ambrosioides L.: Ethnopharmacological evaluation and clinical field trials. Soc Sci Med. 1985; 21(8): 879-86. [DOI:10.1016/0277-9536(85)90144-3]
65. Boskabady MH, Alitaneh S, Alavinezhad A. Carum copticum L.: A herbal medicine with various pharmacological effects. Biomed Res Int. 2014; 2014: 1-11. [DOI:10.1155/2014/569087]
66. Mathew N, Misra-Bhattacharya S, Perumal V, Muthuswamy K. Antifilarial lead molecules isolated from Trachyspermum ammi. Molecules. 2008; 13( 9): 2156-2168. [DOI:10.3390/molecules13092156]
67. Moazeni M, Saharkhiz MJ, Hosseini AA. In vitro lethal effect of ajowan (Trachyspermum ammi L.) essential oil on hydatid cyst protoscoleces. Vet Parasitol. 2012; 187(1): 203-8. [DOI:10.1016/j.vetpar.2011.12.025]
68. Kamaraj C, Kaushik NK, Rahuman AA, Mohanakrishnan D, Bagavan A, Elango G. Antimalarial activities of medicinal plants traditionally used in the villages of Dharmapuri regions of South India. J Ethnopharmacol. 2012; 141(3): 796-802. [DOI:10.1016/j.jep.2012.03.003]
69. Manjili HK, Jafari H, Ramazani A, Davoudi N. Anti-leishmanial and toxicity activities of some selected Iranian medicinal plants. Parasitol Res. 2012; 111(5): 2115-21. [DOI:10.1007/s00436-012-3059-7] [PubMed] [Google Scholar]
70. Shahabi S, Ayazi Roozbehani F, Kamalinejad M, Abadi A. Anti-giardia activity of Carum copticum on Giardia lamblia cysts in vitro. Pejouhesh. 2008; 32(4): 303-7. [Google Scholar]
71. Ribero D, Nuzzo G, Amisano M, Tomatis M, Guglielmi A, Giulini SM. Comparison of the prognostic accuracy of the sixth and seventh editions of the TNM classification for intrahepatic cholangiocarcinoma. HPB. 2011; 13(3): 198-205. [DOI:10.1111/j.1477-2574.2010.00271.x] [PubMed] [Google Scholar]
72. Park I-K, Kim J, Lee S-G, Shin S-C. Nematicidal activity of plant essential oils and components from ajowan (Trachyspermum ammi), allspice (Pimenta dioica) and litsea (Litsea cubeba) essential oils against pine wood nematode (Bursaphelenchus xylophilus). J nematol. 2007; 39(3): 275. [PubMed]
73. Wright DJ. Nematicides: mode of action and new approaches to chemical control. Plant parasit nematod. 1981; 3: 421-449. [DOI:10.1016/B978-0-12-782203-7.50023-6] [Google Scholar]
74. Zaman MA, Iqbal Z, Abbas RZ, Khan MN. Anticoccidial activity of herbal complex in broiler chickens challenged with Eimeria tenella. Parasitol. 2012; 139(02): 237-243. [DOI:10.1017/S003118201100182X] [PubMed] [Google Scholar]
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