Tue, Apr 16, 2024
Volume 13, Issue 6 (Nov-Dec 2019)
mljgoums 2019, 13(6): 11-16 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Abbasi M, Asadi A, Musavi H. Association of Liver Aminotransferases with Lipid Profile in Patients with Type II Diabetes Mellitus. mljgoums 2019; 13 (6) :11-16
URL: http://mlj.goums.ac.ir/article-1-1242-en.html
URL: http://mlj.goums.ac.ir/article-1-1242-en.html
Association of Liver Aminotransferases with Lipid Profile in Patients with Type II Diabetes Mellitus
1- Veterinary Medicine, Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
2- Veterinary Medicine, Faculty of Veterinary Medicine, Karaj Branch, Islamic Azad University, Karaj, Iran
3- Department of Biochemistry, Faculty of Basic Science, Razi University Kermanshah, Iran
2- Veterinary Medicine, Faculty of Veterinary Medicine, Karaj Branch, Islamic Azad University, Karaj, Iran
3- Department of Biochemistry, Faculty of Basic Science, Razi University Kermanshah, Iran
Abstract: (5343 Views)
Background and Objectives: Reduced insulin secretion in Type II Diabetes Mellitus (T2DM) results in fat accumulation in hepatocytes and increase in liver enzymes. The hepatocyte destruction due to non-alcoholic fatty liver is associated with increased risk of cardiovascular diseases. Therefore, the aim of this study is to evaluate the association of liver transaminases with lipid profile in T2DM patients compared to healthy subjects.
Methods: A total of 1000 subjects (500 males and females with T2DM and 500 healthy subjects) participated in this case-control study. Diagnosis of T2DM was made based on the World Health Organization (WHO) criteria. Fasting blood samples (5 ml) were obtained from all subjects in the morning and the serum was extracted for the assessment of biochemical parameters was used to compare parameters between healthy and T2DM patients. Data were analyzed by SPSS version 20 and using Mann-Whitney test and Spearman correlation coefficient.
Results: The serum total cholesterol (TCH), triglyceride, Alanine Aminotransferase (ALT), Aspartate Transaminase (AST), TCH/high density lipoprotein (HDL-C) ratio and atherogenecity index plasma were significantly higher in T2DM group compared to healthy individuals (p≤0.006). Among the lipid profile parameters only Risk ratio (TCH/HDL-C) was positively correlated with ALT (p=0.037) while no significant correlation was observed for other variables (P>0.05)
Conclusion: T2DM Patients have higher lipid profile, atherogenecity index and liver enzymes compared to healthy individuals. Furthermore, TCH/HDL-C was significantly correlated with ALT.
Methods: A total of 1000 subjects (500 males and females with T2DM and 500 healthy subjects) participated in this case-control study. Diagnosis of T2DM was made based on the World Health Organization (WHO) criteria. Fasting blood samples (5 ml) were obtained from all subjects in the morning and the serum was extracted for the assessment of biochemical parameters was used to compare parameters between healthy and T2DM patients. Data were analyzed by SPSS version 20 and using Mann-Whitney test and Spearman correlation coefficient.
Results: The serum total cholesterol (TCH), triglyceride, Alanine Aminotransferase (ALT), Aspartate Transaminase (AST), TCH/high density lipoprotein (HDL-C) ratio and atherogenecity index plasma were significantly higher in T2DM group compared to healthy individuals (p≤0.006). Among the lipid profile parameters only Risk ratio (TCH/HDL-C) was positively correlated with ALT (p=0.037) while no significant correlation was observed for other variables (P>0.05)
Conclusion: T2DM Patients have higher lipid profile, atherogenecity index and liver enzymes compared to healthy individuals. Furthermore, TCH/HDL-C was significantly correlated with ALT.
Research Article: Original Paper |
Subject:
Biochemistry
Received: 2019/08/18 | Accepted: 2019/08/18 | Published: 2019/08/18 | ePublished: 2019/08/18
Received: 2019/08/18 | Accepted: 2019/08/18 | Published: 2019/08/18 | ePublished: 2019/08/18
References
1. Van Dieren S, Beulens JW, van Grobbee DE, der Schouw YT, Neal B. The global burden of diabetes and its complications: an emerging pandemic. Eur J Cardiovasc Prev Rehabil. 2010; 17 Suppl 1:S3-8. doi: 10.1097/01.hjr.0000368191.86614.5a. [DOI:10.1097/01.hjr.0000368191.86614.5a]
2. Esteghamati A, Etemad K, Koohpayehzadeh J, Abbasi M, Meysamie A, Noshad S, et al. Trends in the prevalence of diabetes and impaired fasting glucose in association with obesity in Iran: 2005-2011. Diabetes Res Clin Pract. 2014; 103(2): 319-27. doi: 10.1016/j.diabres.2013.12.034. [DOI:10.1016/j.diabres.2013.12.034]
3. Ebrahimi-Far M, Mazdapour M, Kaki A, Mohammadi P, Zakerjafari M, Lavi A. Comparison of Biochemical Factors and Liver Enzymes in type 2 Diabetes Patients and Healthy Individuals. Bulletin of Environment, Pharmacology and Life Sciences. 2015; 4: 1-4.
4. Balaji A, Suhas B, Ashok M, Mangesh T. Serum Alanine Transaminases and Lipid Profile in Type 2 Diabetes Mellitus Indian Patients. Journal of Research in Diabetes.
2013 (2013):1-7. DOI: 10.5171/2013. 613176. [DOI:10.1155/2013/625019]
5. Rajeswari S, Kumar A, Gandhi M, Swaminathan S. Association between Lipid Profile and Liver Function Tests in Diabetic Patients. Int J Pure App Biosci. 2014; 2(4): 26-31.
6. Harris EH. Elevated liver function tests in type 2 diabetes. Clinical diabetes. 2005; 23(3 SRC - BaiduScholar): 115-9. [DOI:10.2337/diaclin.23.3.115]
7. Targher G, Valbusa F, Bonapace S, Bertolini L, Zenari L, Rodella S, et al. Non-alcoholic fatty liver disease is associated with an increased incidence of atrial fibrillation in patients with type 2 diabetes. PLoS One. 2013; 8(2): e57183. doi: 10.1371/journal.pone.0057183. [DOI:10.1371/journal.pone.0057183]
8. Prashanth M, Ganesh H, Vima M, John M, Bandgar T, Joshi SR, et al. Prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus. Medicine (Baltimore). 2017; 96(39): e8179. doi: 10.1097/MD.0000000000008179. [DOI:10.1097/MD.0000000000008179]
9. Anstee QM, Targher G, Day CP. Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis. Nat Rev Gastroenterol Hepatol. 2013; 10(6): 330-44. doi: 10.1038/nrgastro.2013.41. [DOI:10.1038/nrgastro.2013.41]
10. Woreta TA, Alqahtani SA. Evaluation of abnormal liver tests. Med Clin North Am. 2014; 98(1): 1-16. doi: 10.1016/j.mcna.2013.09.005. [DOI:10.1016/j.mcna.2013.09.005]
11. Esteghamati A, Noshad S, Khalilzadeh O, Khalili M, Zandieh A, Nakhjavani M. Insulin resistance is independently associated with liver aminotransferases in diabetic patients without ultrasound signs of nonalcoholic fatty liver disease. Metab Syndr Relat Disord. 2011; 9(2):111-7. doi: 10.1089/met.2010.0066. [DOI:10.1089/met.2010.0066]
12. Chen S, Guo X, Chen Y, Dong S, Sun Y. Prevalence of abnormal serum liver enzymes in patients with type 2 diabetes mellitus: a cross-sectional study from China. Postgraduate medicine. 2016; 128(8): 770-6. [DOI:10.1080/00325481.2016.1242366]
13. Shrestha N, Bhatt NP, Neopane P, Dahal S, Regmi P, Khanal M, et al. Hepatic Involvement with Elevated Liver Enzymes in Nepalese Subjects with Type 2 Diabetes Mellitus. Int J Biochem Res Rev. 2017; 16: 1-8. doi: 10.7759/cureus.3626 [DOI:10.7759/cureus.3626]
14. Barlow SE, Dietz WH. Obesity evaluation and treatment: expert committee recommendations. Pediatrics. 1998; 102(3): e29-e. [DOI:10.1542/peds.102.3.e29]
15. Al-Jameil N, Khan FA, Arjumand S, Khan MF, Tabassum H. Associated liver enzymes with hyperlipidemic profile in type 2 diabetes patients. Int J Clin Exp Pathol. 2014; 7(7): 4345-4349.
16. Marjani A, Veghari G, Badeleh MT. Serumlipidperoxidation and leptin levels in male and female type 2 diabetic patients in Gorgan (South East of Caspian Sea), Iran. Journal of Chinese Clinical Medicine. 2010; 5(1): 26-35.
17. Ali F, Jamil H, Anwar SS, Wajid N. Characterization of lipid parameters in diabetic and non-diabetic atherosclerotic patients. J Geriatr Cardiol. 2015 Jan;12(1):37-43. doi: 10.11909/j.issn.1671-5411.
18. Williams K, Tchernof A, Hunt KJ, Wagenknecht LE, Haffner SM, Sniderman AD. Diabetes, abdominal adiposity, and atherogenic dyslipoproteinemia in women compared with men. Diabetes. 2008; 57(12): 3289-96. doi: 10.2337/db08-0787. [DOI:10.2337/db08-0787]
19. West J, Brousil J, Gazis A, Jackson L, Mansell P, Bennett A, et al. Elevated serum alanine transaminase in patients with type 1 or type 2 diabetes mellitus. QJM. 2006; 99(12): 871-6. [DOI:10.1093/qjmed/hcl116]
20. Lee B-C, Lee J. Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance. Biochim Biophys Acta. 2014; 1842(3): 446-62. doi: 10.1016/j.bbadis.2013.05.017. [DOI:10.1016/j.bbadis.2013.05.017]
21. Yang P, Zhou W, Li C, Zhang M, Jiang Y, Jiang R, et al. Kupffer-cell-expressed transmembrane TNF-α is a major contributor to lipopolysaccharide and D-galactosamine-induced liver injury. Cell and tissue research. 2016; 363(2): 371-83. doi: 10.1007/s00441-015-2252-2. [DOI:10.1007/s00441-015-2252-2]
22. Mohamed J, Nazratun Nafizah AH, Zariyantey AH, Budin SB. Mechanisms of Diabetes-Induced Liver Damage: The role of oxidative stress and inflammation. Sultan Qaboos Univ Med J. 2016; 16(2):e132-41. doi: 10.18295/squmj.2016.16.02.002. [DOI:10.18295/squmj.2016.16.02.002]
23. Pastori D, Polimeni L, Baratta F, Pani A, Del Ben M, Angelico F. The efficacy and safety of statins for the treatment of non-alcoholic fatty liver disease. Dig Liver Dis. 2015; 47(1): 4-11. doi: 10.1016/j.dld.2014.07.170. [DOI:10.1016/j.dld.2014.07.170]
24. Lemieux I, Lamarche B, Couillard C, Pascot A, Cantin B, Bergeron J, et al. Total cholesterol/HDL cholesterol ratio vs LDL cholesterol/HDL cholesterol ratio as indices of ischemic heart disease risk in men: the Quebec Cardiovascular Study. Archives of internal medicine. 2001; 161(22): 2685-92. [DOI:10.1001/archinte.161.22.2685]
25. Atiba AS, Oparinde DP, Babatunde OA, Niran-Atiba T, Jimoh AK, Adepeju A. Liver enzymes and lipid profile among type 2 diabetic patients in Osogbo, Nigeria . Greener Journal of Medical Sciences. 2013; 3(5 SRC - BaiduScholar):174-8. [DOI:10.15580/GJMS.2013.5.011313373]
26. Kashinakunti S, Gurupadappa S, Kallaganada. Correlation between liver enzymes and lipid profile in type II diabetes mellitus-A case control study. IOSR Journal of Biotechnology and Biochemistry. 2017; 3(5): 1-5.
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Enamad
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.