Volume 14, Issue 6 (Nov-Dec 2020)                   mljgoums 2020, 14(6): 17-22 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Vizvari E, farzanegi P, Abbas Zade H. Effect of Moderate Aerobic Exercise on Serum Levels of FGF21 and Fetuin A in Women with Type 2 Diabetes. mljgoums. 2020; 14 (6) :17-22
URL: http://mlj.goums.ac.ir/article-1-1229-en.html
1- Assistant professor, Department of exercise physiology, Faculty of Humanities, Shams Institute of Higher Education, Gonbad Kavous, Iran , vizvariexir@yahoo.com
2- Department of Exercise Physiology, Faculty of Humanities
Abstract:   (397 Views)

Background and objectives: Fibroblast growth factor 21 (FGF21) and fetuin A are thought to be involved in the pathogenesis of metabolic disorders, such as type 2 diabetes. On the other hand, regular physical activity has an important role in the prevention and management of type 2 diabetes. The purpose of this study was to investigate effect of moderate aerobic exercise on serum levels of FGF21 and fetuin A in women with type 2 diabetes.

Methods: This was a semi-experimental study with a pretest-posttest design. The study was performed on 28 women with type 2 diabetes aged 40-50 years (mean weight: 70.58 ± 2.11) who were randomly divided into an exercise group (n=14) and a control group (n=14). The training intervention consisted of eight weeks of moderate aerobic exercise at 60-70% of maximum heart rate, five times a week. Serum levels of FGF21, fetuin A and some metabolic parameters were evaluated before the first session and 48 hours after the last session. All statistical analyses were performed in SPSS (version 24) using repeated measures ANOVA and at significance of 0.05. 
Results: The eight-week aerobic training intervention caused a significant increase in FGF21 and insulin sensitivity as well as a significant decrease in fetuin A, fasting blood sugar and HbA1c (P=0.001).
Conclusion: As a complementary therapy, regular aerobic exercise can be beneficial for type 2 diabetes patients in improving some metabolic parameters as well as FGF21 and fetuin A levels.
Full-Text [PDF 810 kb]   (92 Downloads)    
Research Article: Original Paper | Subject: Sport Physiology
Received: 2019/07/6 | Accepted: 2019/08/18 | Published: 2020/10/29 | ePublished: 2020/10/29

1. Ghane M. Investigation of Frequency of Herpes Simplex Virus in Patients with Type 2 Diabetes and Healthy Individuals by PCR and ELISA. Mljgoums. 2018; 12(1):6-10. [DOI:10.29252/mlj.12.1.6] [Google Scholar]
2. Vahedi M, Farzanegi P. The Effect of Portulacaoleracea L Consumption and Regular Exercise on Levels of Cathepsin S, Cystatin C And C-Reactive Protein in Diabetic Women. Mljgoums. 2015; 9(4): 47-53. DOI: 10.18869/acadpub.mlj.9.4.47. [DOI:10.18869/acadpub.mlj.9.4.47] [Google Scholar]
3. Mook Choi K. The Impact of Organokines on Insulin Resistance, Inflammation and Atherosclerosis. Endocrinology and Metabolism. 2016; 31(1): 1-6. http://dx.doi.org/10.3803/EnM.2016.31.1.1 [DOI:10.3803/EnM.2016.31.1.1] [PubMed] [Google Scholar]
4. Oh KJ, Lee DS, Kim WK, Han BS, Lee SC, Bae K-H. Metabolic Adaptation in Obesity and Type II Diabetes: Myokines, Adipokines and Hepatokines. Int J Mol Sci. 2016; 18(1). pii: E8. doi: 10.3390/ijms18010008. [DOI:10.3390/ijms18010008] [PubMed] [Google Scholar]
5. Jin Yoo H, Mook Choi Qu. Hepatokines as a Link between Obesity a Cardiovascular Diseases. Review. Diabetes Metab J. 2015; 39: 10-15. doi: 10.4093/dmj.2015.39.1.10. [DOI:10.4093/dmj.2015.39.1.10] [PubMed] [Google Scholar]
6. Masanori Emoto M, Mori K, Lee E, Shoji T, Inaba M, Nishizawa Y. Fetuin-A and atherosclerotic calcified plaque in patients with type 2 diabetes mellitus. Metabolism. 2010; 59(6): 873-878. [DOI:10.1016/j.metabol.2009.10.005] [PubMed] [Google Scholar]
7. Sigal R, Armstrong M, Colby P, Kenny G, Plotnikoff G, Reichert S, et al. Physical Activity and Diabetes. Can J Diabetes. 2013; 37: 40-44. DOI: https://doi.org/10.1016/j.jcjd.2017.10.008 [DOI:10.1016/j.jcjd.2017.10.008.] [PubMed] [Google Scholar]
8. Colberg Sh, Sigal R, Yardly J, Riddell M, dunstan D, Demosey P, et al. Physical activity exercise and diabetes a position statement of the american diabetes association. Diabetes Care. 2016; 39(11): 2065-2079. doi: 10.2337/dc16-1728. [DOI:10.2337/dc16-1728] [PubMed] [Google Scholar]
9. Asle Mohammadi Zadeh M, Kargarfard M, Nazarali P. Comparison Of The Effects Of Interval Training With Different Diet On Il-6, Tnf-Α And Some Of Metabolic Indexes In Obesity Type 2 Diabetic Men. ijdld. 2019; 18(3) :156-172. [Google Scholar]
10. Azali Alamdari K, Khalafi M. The effect of high intensity interval training on serum level of FGF21 and insulin resistance in obese men . ijdld. 2019; 18(1): 41-48. [Google Scholar]
11. Cuevas-Ramos D, Almeda-Valdés P, Meza-Arana CE, Brito-Córdova G, Gómez-Pérez FJ, Mehta R, et al. Exercise increases serum fibroblast growth factor 21 (FGF21) levels. PLos One. 2012; 7(5): e38022. [DOI:10.1371/journal.pone.0038022] [PubMed] [Google Scholar]
12. Besse-Patin A, Montastier E, Vinel C, Castan-Laurell I, Louche K, Dray C, et al. Effect of endurance training on skeletal muscle myokine expression in obese men: identification of apelin as a novel myokine. Int J obes (Land). 2014; 38(5): 707-13. [DOI:10.1038/ijo.2013.158] [PubMed] [Google Scholar]
13. Yang SJ, Hong HC, Choi HY, Yoo HJ, Cho GJ, Hwang TG, et al. Effects of a three-month combined exercise programme on fibroblast growth factor 21 and fetuin-A levels and arterial stiffness in obese women. Clin Endocrinol(oxf). 2011; 75(4): 464-9.doi: 10.1111/j.1365-2265.2011.04078.x. [DOI:10.1111/j.1365-2265.2011.04078.x] [PubMed] [Google Scholar]
14. Malin S, del Rincon J, Huang H, Kirwan JP. Exercise-induced lowering of fetuin-A may increase hepatic insulin sensitivity. Med Sci Sports Exerc. 2014; 46: 2085-2090. doi: 10.1249/MSS.0000000000000338. [DOI:10.1249/MSS.0000000000000338] [PubMed] [Google Scholar]
15. Schultes B, Frick J, Ernst B, Stefan N, Fritsche A. The effect of 6-weeks of aerobic exercise training on serum fetuin-A levels in non-diabetic obese women. Exp Clin Endocrinol Diabetes. 2010; 118(10): 754-756. [DOI:10.1055/s-0030-1253418] [PubMed] [Google Scholar]
16. Vizvari E, Farzanegi P, Abbaszadesourati H. Effect of Moderate Aerobic Training on Serum Levels of Angiogenic and Angiostatic Factors in Women with Type 2 Diabetes. Sjimu. 2019; 27(1): 112-121. [DOI:10.29252/sjimu.27.1.112] [Google Scholar]
17. Vizvari E, Farzanegi P, Abbas Zade Sourati H.s. P Effect of Moderate Aerobic Training on Serum Levels of Angiogenic and Angiostatic Factors in Women with Type 2 Diabetes. Diabeteathobiol Res. 2018; 21(3): 125-131. [Google Scholar]
18. Gimeno RE, Moller DE. FGF21-based pharmacotherapy: potential utility for metabolic disorders. Trends Endocrinol Metab. 2014; 25(6): 303-11. [DOI:10.1016/j.tem.2014.03.001] [PubMed] [Google Scholar]
19. Abbasi Daloii A, Maleki Delarestaghi A. The effect of Aerobic exercise on Fibroblast Growth Factor and Adiponectin in obese men. Journal of Sport Biosciences. 2017; 9(1): 109-121. [Google Scholar]
20. Vizvari E, Farzanegi P, Abbas Zade Sourati H. Effect of Vigorous Aerobic Exercise on Serum Levels of SIRT1, FGF21 and Fetuin A in Women with Type II Diabetes. Mljgoum. 2018; 12(2):1-6. DOI: 10.29252/mlj.12.2.1. [DOI:10.29252/mlj.12.2.1] [Google Scholar]
21. Scalzo R, Peltonen G, Giordano G, Binns S, Klochak A, Paris A, et al. Regulators of Human White Adipose Browning: Evidence for Sympathetic Control and Sexual Dimorphic Responses to Sprint Interval Training. PLoS One. 2014; 9(3): e90696. [DOI:10.1371/journal.pone.0090696] [PubMed] [Google Scholar]
22. Hansen JS, Pedersen BK, Xu G, Lehmann R, Weigert C, Plomgaard P. Exercise-Induced Secretion of FGF21 and Follistatin Are Blocked by Pancreatic Clamp and Impaired in Type 2 Diabetes. J Clin Endocrinol Metab. 2016; 101(7): 2816-2825. doi: 10.1210/jc.2016-1681. [DOI:10.1210/jc.2016-1681] [PubMed] [Google Scholar]
23. Li Xia, Ge H, Weiszmann J, Hecht R, Li Y, Véniant M, Xu J, Wu X, Lindberg R, Li Y. Inhibition of lipolysis may contribute to the acute regulation of plasma FFAand glucose by FGF21 inob/ob mices. FEBS letters 2009; 583(19): 3230-3234 [DOI:10.1016/j.febslet.2009.09.012] [PubMed] [Google Scholar]
24. Zhu Sh, Ma L, Wu Y, Ye X, Zhang T, Zhang Q, Rasoul L, Liu Y, Guo M, Zhou B, Ren G and Li D. FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway. Acta Biochim Biophys Sin(ABBS) 2014; 46: 1041-1048. [DOI:10.1093/abbs/gmu097] [PubMed] [Google Scholar]
25. Chau M, Gao J, Yang Q, Zhidan Wu, and Gromada J. Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC1α pathway. Proc Natl Acad Sci U S A. 2010; 107(28): 12553-12558. doi: 10.1073/pnas.1006962107. [DOI:10.1073/pnas.1006962107] [PubMed] [Google Scholar]
26. Nara R, Scherolin O. Treadmill training increases SIRT1 and PGC1 α protein levels and AMPK phosphorylation in quadriceps of middle-aged rats in an intensity-dependent manner. Mediators Inflamm 2014; 2014: 1-11. [PubMed] [Google Scholar]
27. Lee S, Norheim F, Gulseth H , Langleite M , Kolnes K , Tangen D et al. Interaction between plasma fetuin‐A and free fatty acids predicts changes in insulin sensitivity in response to long‐term exercise. Physiol Rep 2017; 5(5): e13183. doi: 10.14814/phy2.13183. [DOI:10.14814/phy2.13183] [PubMed] [Google Scholar]
28. Salama ME, El-Damarawi MA. Effect of two exercise varieties on fetuin-A plasma level in experimental diabetic nephropathy. Tanta Med J. 2017; 45(1): 21-28. [DOI:10.4103/tmj.tmj_44_16] [Google Scholar]
29. Blumenthal J, Gitterman A, Ryan A, Prio S. Effects of Exercise Training and Weight Loss on Plasma Fetuin-A Levels and Insulin Sensitivity in Overweight Older Men. J Diabetes Res. 2017; 2017:1492581.doi: 10.1155/2017/1492581. [DOI:10.1155/2017/1492581] [PubMed] [Google Scholar]
30. Sun Q, Cornelis MC, Manson JE, Hu FB. Plasma levels of fetuin-A and hepatic enzymes and risk of type 2 diabetes in women in the U.S. Diabetes. 2013; 62(1): 49-55.doi: 10.2337/db12-0372. [DOI:10.2337/db12-0372] [PubMed] [Google Scholar]

Add your comments about this article : Your username or Email:

Send email to the article author

© 2007 All Rights Reserved | Medical Laboratory Journal