Volume 13, Issue 4 (Jul-Aug 2019)                   mljgoums 2019, 13(4): 1-4 | Back to browse issues page


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Kelishadi M, Kelishadi M, Ashrafi G, Tabarraei A. Investigation of the Possible Association between Human Cytomegalovirus and Pterygium Development . mljgoums. 2019; 13 (4) :1-4
URL: http://mlj.goums.ac.ir/article-1-1212-en.html
1- Laboratory Sciences Research Center, Golestan University of Medical Science, Gorgan, Iran; and Department of Virology, Pasteur Institute of Iran, Tehran, Iran
2- Department of Ophthalmology, 5th Azar Hospital, Gorgan, Iran
3- Kingston University London, Cancer Theme, School of Life Science, Pharmacy and Chemistry, SEC Faculty, Kingston upon Thames, KT12EE, London, UK
4- Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran , alijant@yahoo.com
Abstract:   (570 Views)
ABSTRACT
            Background and Objectives: Pterygium is a common ocular surface lesion that manifest as wing-shaped, benign conjunctival growth, which can extend onto the corneal surface. Presence of some oncogenic viruses in pterygium and the neoplastic nature of the lesion led us to the postulated involvement of the viruses in the etiology of pterygia. The aim of this study was to evaluate prevalence and possible role of human cytomegalovirus (HCMV) in the formation of pterygia.
            Methods: Fifty pterygium specimens and 10 normal conjunctival biopsy specimens (controls) were investigated by polymerase chain reaction using primers specific for the highly conserved regions of major capsid protein gene of HCMV. Data were analyzed using SPSS statistical software (IBM SPSS Statistics 18; IBM Corporation, USA) at significance level of 0.05.
            Results: The HCMV DNA was detected in seven (14%) patients with pterygium but in none of the control subjects. All subjects were β-globin positive.
            Conclusion: Given the results, direct involvement of HCMV in the development of pterygium seems less probable, thus suggesting that other agents might be involved in the multistep process of the disease.
            Keywords: Human Cytomegalovirus, Pterygium, Polymerase Chain Reaction.
Full-Text [PDF 716 kb]   (129 Downloads)    
Type of Study: Original Paper | Subject: Microbiology
Received: 2019/04/29 | Accepted: 2019/04/29 | Published: 2019/04/29 | ePublished: 2019/04/29

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