Volume 13, Issue 3 (May-Jun 2019)                   mljgoums 2019, 13(3): 1-5 | Back to browse issues page

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Alirezaei F, Ghanbari-Niaki A, Joshaghani H, Naghizadeh Ghomi M. Effect of Aerobic Interval Training on Plasma Apolipoprotein M Levels in Young Men. mljgoums. 2019; 13 (3) :1-5
URL: http://mlj.goums.ac.ir/article-1-1195-en.html
1- Department of Exercise Biochemistry Divisiony, Faculty of Sports Sciences, University of Mazandaran, Babolsar, Iran
2- Exercise Biochemistry Division, Faculty of Sport Sciences, University of Mazandaran, Babolsar, Iran , ghanbara@umz.ac.ir
3- Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran
4- Faculty of Mathematics, University of Mazandaran, Babolsar, Iran
Abstract:   (916 Views)
             Background and Objectives: Apolipoprotein M (APOM) is a novel high-density lipoprotein (HDL)-associated protein involved in the production of pre-beta HDL and cholesterol efflux to HDL. The present study examined effect of 12 weeks of aerobic interval training on HDL-associated APOM levels.
             Methods: Study population included 20 healthy men aged 20 to 24 years. The subjects were randomly and equally divided into a training group and a control group. Each training session included 10 minutes of warm-up, 35 minutes of aerobic training (5 combined cycles each including four minutes of running at intensity of 85-95% and an active resting period of treadmill running at 65-75% of maximum heart rate for 3 minutes) and 10 minutes of cool-down. Blood samples (10 mL) were taken every four weeks. Two-way ANOVA and Bonferroni's post hoc test were used to compare the groups. A P-value of less than 0.05 was considered statistically significant.
             Results: At the end of the 12th week, HDL-associated APOM levels increased in the training group and decreased in the control group. However, these changes were not statistically significant (P>0.05). 
             Conclusion: This study demonstrated that the 12-week aerobic interval training does not significantly affect HDL-associated APOM levels. However, it is recommended to monitor subjects’ diet throughout the study period to reach a more comprehensive conclusion. 
             Keywords: Aerobic interval training, Apolipoprotein M, Young men.
Full-Text [PDF 664 kb]   (302 Downloads)    
Type of Study: Original Paper | Subject: Sport Physiology
Received: 2019/03/2 | Accepted: 2019/03/2 | Published: 2019/03/2 | ePublished: 2019/03/2

1. Asadpour M, Pardal AH, Rajabian A, Abdollahi M. Investigation of fibrinogen and CRP changes following aspirin receipt in individuals with cardiovascular disease. PajoohandeJ. 2006.
2. Braith RW, Stewart KJ. Resistance exercise training: Its role in the prevention of cardiovascular disease. Circulation. 2006; 113(22): 2642-50. DOI:10.1161/CIRCULATIONAHA.105.584060. [DOI:10.1161/CIRCULATIONAHA.105.584060]
3. McGrowder D, Riley CA, Morrison EYSt, Gordon L. The Role of High-Density Lipoproteins in Reducing the Risk of Vascular Diseases, Neurogenerative Disorders, and Cancer. Cholesterol. 2011; 2011: 496925. doi: 10.1155/2011/496925. [DOI:10.1155/2011/496925]
4. Lunt H, Draper N, Marshall HC, Logan FJ, Hamlin MJ, Shearman JP, Cotter JD, et al. High Intensity Interval Training in a Real World Setting: A Randomized Controlled Feasibility Study in Overweight Inactive Adults, Measuring Change in Maximal Oxygen Uptake. PLoS ONE. 2014; 9(1): e 83256. doi:10.1371/journal.pone.0083256. [DOI:10.1371/journal.pone.0083256]
5. Cervin C, Axler O, Holmkvist J, Almgren P, Rantala E, Tuomi T, et al. An investigation of serum concentration of APOM as a potential MODY3 marker using a novel ELISA. J Intern Med. 2010; 267 [DOI:10.1111/j.1365-2796.2009.02145.x]
6. Xu N, Dahlback B. A Novel Human Apolipoprotein (APOM). J Biol Chem. 1999; 274: 31286-90. [DOI:10.1074/jbc.274.44.31286]
7. Axler O, Ahnström J, Dahlbäck B. An Elisa For Apolipoprotein M Reveals A Strong Correlation To Total Cholesterol In Human Plasma. J Lipid Res. 2007; 48(8): 1772-80. [DOI:10.1194/jlr.M700113-JLR200]
8. Ghanbari-Niaki A. Plasma Apolipoprotein-M (APOM) Response to a Circuit Resistance Training Program. Ann Appl Sport Sci. 2013; 1(4): 1-4.
9. Książek M, Charmas M, Klusiewicz A, Zabielski P, Długołęcka B, Chabowski A, et al. Endurance training selectively increases high-density lipoprotein-bound sphingosine-1-phosphate in the plasma. Scand J Med Sci Sports. 2018; 28(1): 57-64. [DOI:10.1111/sms.12910]
10. Christoffersen C, Obinata H, Kumaraswamy SB, Galvani S, Ahnström J, Sevvana M, et al. Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M. Proc Natl Acad Sci U S A. 2011; 108(23): 9613-8. doi: 10.1073/pnas.1103187108. [DOI:10.1073/pnas.1103187108]
11. Vaisar T. Proteomics investigations of HDL: challenges and promise. Curr Vasc Pharmacol. 2012; 10(4): 410-21. [DOI:10.2174/157016112800812755]
12. Feingold KR, Shigenaga JK, Chui LG, Moser A, Khovidhunkit W, Grunfeld C. Infection and inflammation decrease apolipoprotein M expression. Atherosclerosis. 2008; 199(1): 19-26. [DOI:10.1016/j.atherosclerosis.2007.10.007]
13. Baranowski M, Górski J, Klapcinska B, Waskiewicz Z, Sadowska-Krepa E. Ultramarathon run markedly reduces plasma sphingosine-1-phosphate concentration. Int J Sport Nutr Exerc Metab. 2014; 24(2): 148-56. doi: 10.1123/ijsnem.2013-0093. [DOI:10.1123/ijsnem.2013-0093]
14. Baranowski M, Charmas M, Długołęcka B, Górski J. Exercise increases plasma levels of sphingoid base-1 phosphates in humans. Acta Physiol (Oxf). 2011;203(3):373-80. [DOI:10.1111/j.1748-1716.2011.02322.x]
15. Nielsen LB, Christoffersen C, Ahnström J, Dahlbäck B. APOM: gene regulation and effects on HDL metabolism. Trends Endocrinol Metab. 2009; 20 [DOI:10.1016/j.tem.2008.11.003]
16. Zhang X1, Mao S, Luo G, Wei J, Berggren-Söderlund M, Nilsson-Ehle P, Xu N. Effects of simvastatin on apolipoprotein M in vivo and in vitro. Lipids Health Dis. 2011 Jul 5;10:112. [DOI:10.1186/1476-511X-10-112]
17. Mulya A, Seo J, Brown A, Gebre AK, Boudyguina E, Shelness G, et al. Apolipoprotein M Expression Increases The Size Of Nascent Preβ Hdl Formed By Atp Binding Cassette Transporter A1. J Lipid Res. 2010; 51(3): 514-524. doi: 10.1194/jlr.M002162. [DOI:10.1194/jlr.M002162]
18. Di D, Wang Z, Liu Y, Luo G, Shi Y, Berggren-Söderlund M, Nilsson-Ehle P, et al. Abca1 Upregulating Apolipoproein M Expression Mediates Via The Rxr/Lxr Pathway In Hepg2 Cells. Biochem Biophys Res Commun.

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