Volume 13, Issue 1 (Jan-Feb 2019)                   mljgoums 2019, 13(1): 28-32 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Barooti E, Darvish S, Kariman N, Yazdanpanah G. Comparison of Human Chorionic Gonadotropin Test and Amnisure Test for Diagnosis of Premature Rapture of Membrane. mljgoums 2019; 13 (1) :28-32
URL: http://mlj.goums.ac.ir/article-1-1158-en.html
1- Department of Obstetrics & Gynecology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Faculty of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- Students' Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:   (6206 Views)
ABSTRACT
             Background and objectives: Accurate diagnosis of preterm rupture of membrane (PROM) is critical during pregnancy, and researchers are seeking ways to decrease the rate of false negative results in diagnostic tests. In the present study, we compare diagnostic properties of Amnisure test and human chorionic gonadotropin (hCG) test for diagnosis of PROM.
             Methods: The study was performed on singleton pregnant women (gestational age: 20 to 41 weeks) who were referred to the Taleghani Hospital in Tehran (Iran) between December 2016 and December 2017. The study included 44 PROM patients and 44 control pregnant women. Speculum examination for cervicovaginal fluid washing, hCG test and Amnisure test were performed for all of patients.  Statistical analysis of data was performed in SPSS software package (Version 18, Chicago, IL, USA) using t-test, Chi-square test, and Mann-Whitney test. P-values less than 0.05 were considered statistically significant.
             Results: The Amnisure test had better sensitivity and specificity compared with the β-hCG test (95.5% and 97.7% vs. 93.2% and 95.5%). The Amnisure test also had higher positive and negative predictive values than the β-hCG test (97.7% and 95.5% vs. 93.3% and 94.3%). Diagnostic accuracy of the Amnisure test was also higher than that of the β-hCG test (96.6% vs. 94.3%).
             Conclusion: According to the results, the two tests have almost equal diagnostic power for detection of PROM during pregnancy.
             Keywords: Chorionic Gonadotropin, Fetal Membranes, Premature Rupture
Full-Text [PDF 624 kb]   (1488 Downloads)    
Research Article: Original Paper | Subject: Human Genetics
Received: 2018/12/19 | Accepted: 2018/12/19 | Published: 2018/12/19 | ePublished: 2018/12/19

References
1. Gunn GC, Mishell DR Jr, Morton DG. Premature rupture of the fetal membranes. A review. Am J Obstet Gynecol. 1970; 106(3): 469-83. [DOI:10.1016/0002-9378(70)90378-9]
2. Kenyon SL, Taylor DJ, Tarnow-Mordi W, Group OC. Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE I randomised trial. ORACLE Collaborative Group. Lancet. 2001; 357(9261): 979-88. [DOI:10.1016/S0140-6736(00)04233-1]
3. Roberts D, Dalziel S. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev. 2006(3):CD004454. [DOI:10.1002/14651858.CD004454.pub2]
4. Ladfors L, Mattsson LA, Eriksson M, Fall O. Is a speculum examination sufficient for excluding the diagnosis of ruptured fetal membranes? Acta Obstet Gynecol Scand. 1997; 76(8): 739-42. [DOI:10.3109/00016349709024339]
5. Kim YH, Park YW, Kwon HS, Kwon JY, Kim BJ. Vaginal fluid beta-human chorionic gonadotropin level in the diagnosis of premature rupture of membranes. Acta Obstet Gynecol Scand. 2005; 84(8): 802-5. [DOI:10.1111/j.0001-6349.2005.00712.x]
6. Esim E, Turan C, Unal O, Dansuk R, Cengizglu B. Diagnosis of premature rupture of membranes by identification of beta-HCG in vaginal washing fluid. Eur J Obstet Gynecol Reprod Biol. 2003; 107(1): 37-40. [DOI:10.1016/S0301-2115(02)00277-4]
7. Gorodeski IG, Haimovitz L, Bahari CM. Reevaluation of the pH, ferning and nile blue sulphate staining methods in pregnant women with premature rupture of the fetal membranes. J Perinat Med. 1982; 10(6): 286-92. [DOI:10.1515/jpme.1982.10.6.286]
8. de Haan HH, Offermans PM, Smits F, Schouten HJ, Peeters LL. Value of the fern test to confirm or reject the diagnosis of ruptured membranes is modest in nonlaboring women presenting with nonspecific vaginal fluid loss. Am J Perinatol. 1994; 11(1): 46-50. [DOI:10.1055/s-2007-994535]
9. Erdemoglu E, Mungan T. Significance of detecting insulin-like growth factor binding protein-1 in cervicovaginal secretions: comparison with nitrazine test and amniotic fluid volume assessment. Acta Obstet Gynecol Scand. 2004; 83(7): 622-6. DOI:10.1111/j.0001-6349.2004.00343.x. [DOI:10.1111/j.0001-6349.2004.00343.x]
10. Sosa CG, Herrera E, Restrepo JC, Strauss A, Alonso J. Comparison of placental alpha microglobulin-1 in vaginal fluid with intra-amniotic injection of indigo carmine for the diagnosis of rupture of membranes. J Perinat Med. 2014; 42(5): 611-6. doi: 10.1515/jpm-2013-0245. [DOI:10.1515/jpm-2013-0245]
11. ACOG Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 80: premature rupture of membranes. Clinical management guidelines for obstetrician-gynecologists. Obstet Gynecol. 2007; 109(4): 1007-19. [DOI:10.1097/01.AOG.0000263888.69178.1f]
12. Friedman ML, McElin TW. Diagnosis of ruptured fetal membranes. Clinical study and review of the literature. Am J Obstet Gynecol. 1969;104(4):544-50. [DOI:10.1016/S0002-9378(16)34244-2]
13. Petrunin DD, Griaznova IM, Petrunina Iu A, Tatarinov Iu S. Immunochemical identification of organ specific human placental alphal-globulin and its concentration in amniotic fluid. Akush Ginekol (Mosk). 1977; (1): 62-4.
14. Jeurgens-Borst AJ, Bekkers RL, Sporken JM, van den Berg PP. Use of insulin like growth factor binding protein-1 in the diagnosis of ruptured fetal membranes. Eur J Obstet Gynecol Reprod Biol. 2002; 102(1): 11-4. [DOI:10.1016/S0301-2115(01)00560-7]
15. Khooshideh M, Radi V, Hosseini R, Hosseini L. The accuracy of placental alpha-microglobuline-1 test in diagnosis of premature rupture of the membranes. Iran J Reprod Med. 2015; 13(6): 355-60.
16. Temel O, Cogendez E, Selcuk S, Asoglu MR, Kaya E. beta-human chorionic gonadotropin assay in vaginal washing fluid for the accurate diagnosis of premature rupture of membranes during late pregnancy. J Turk Ger Gynecol Assoc. 2013; 14(4): 201-4. doi:10.5152/jtgga.2013.65624. [DOI:10.5152/jtgga.2013.65624]
17. Cousins LM, Smok DP, Lovett SM, Poeltler DM. AmniSure placental alpha microglobulin-1 rapid immunoassay versus standard diagnostic methods for detection of rupture of membranes. Am J Perinatol. 2005;22(6):317-20. DOI:10.1055/s-2005-870896. [DOI:10.1055/s-2005-870896]
18. Lee SE, Park JS, Norwitz ER, Kim KW, Park HS, Jun JK. Measurement of placental alpha-microglobulin-1 in cervicovaginal discharge to diagnose rupture of membranes. Obstet Gynecol. 2007;109(3):634-40. DOI:10.1097/01.AOG.0000252706.46734.0a. [DOI:10.1097/01.AOG.0000252706.46734.0a]
19. Martinez MW, Singh CP, Mookadam F. Transcatheter closure of a postinfarction ventricular septal rupture. J Am Soc Echocardiogr. 2006; 19(11): 1401 e5-7.
20. Mercer BM, Goldenberg RL, Meis PJ, Moawad AH, Shellhaas C, Das A, et al. The Preterm Prediction Study: prediction of preterm premature rupture of membranes through clinical findings and ancillary testing. The National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Am J Obstet Gynecol. 2000; 183(3): 738-45. [DOI:10.1067/mob.2000.106766]
21. Ananth CV, Oyelese Y, Srinivas N, Yeo L, Vintzileos AM. Preterm premature rupture of membranes, intrauterine infection, and oligohydramnios: risk factors for placental abruption. Obstet Gynecol. 2004; 104(1): 71-7. DOI:10.1097/01.AOG.0000128172.71408.a0 [DOI:10.1097/01.AOG.0000128172.71408.a0]
22. Di Renzo GC, Roura LC, Facchinetti F, Antsaklis A, Breborowicz G, Gratacos E, et al. Guidelines for the management of spontaneous preterm labor: identification of spontaneous preterm labor, diagnosis of preterm premature rupture of membranes, and preventive tools for preterm birth. J Matern Fetal Neonatal Med. 2011; 24(5): 659-67. doi: 10.3109/14767058.2011.553694. [DOI:10.3109/14767058.2011.553694]
23. Tian CF, Lv FH, Wang M, Gu XS. Serum beta-human chorionic gonadotropin and interleukin-1 as diagnostic biomarkers for the premature rupture of membranes and chorioamnionitis. Biomed Rep. 2014; 2(6): 905-9. DOI:10.3892/br.2014.342. [DOI:10.3892/br.2014.342]

Add your comments about this article : Your username or Email:
CAPTCHA

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2007 All Rights Reserved | Medical Laboratory Journal

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.