Volume 13, Issue 1 (Jan-Feb 2019)                   mljgoums 2019, 13(1): 1-5 | Back to browse issues page

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Meskini M, Khaledi A, Esmaeili D. Inhibitory Effects of a Herbal Ointment against Pseudomonas aeruginosa . mljgoums. 2019; 13 (1) :1-5
URL: http://mlj.goums.ac.ir/article-1-1145-en.html
1- Department of Microbiology and Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
2- Department of Microbiology, Kashan University of Medical Science, Kashan, Iran
3- Department of Microbiology and Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran, and Applied Virology Research Center, Baqiyatallah University of Medical Sciences
Abstract:   (3863 Views)
            Background and Objectives: Pseudomonas aeruginosa is a gram negative opportunistic pathogen and an important cause of wound infections and nosocomial infections. The purpose of this study was to study inhibitory effects of a new ointment prepared from medicinal plants against P. aeruginosa isolates.
            Methods: In this study, an ointment called ZOUSH was prepared from mixing alcoholic extracts of Satureja khuzestaniea, Zataria multiflora, Mentha mozaffariani Jamzad, honey and polyurethane. Minimal inhibitory concentration of ZOUSH and its compositions alone or combined was determined using the disk diffusion method.
            Results: S. khuzestaniea, Z. multiflora and Mentha mozaffariani Jamzad had inhibitory effects against P. aeruginosa. The ZOUSH ointment had greater antibacterial effects than the any of its compositions used solely or combined. The diameter of inhibition zone had a direct relationship with the concentration of the extracts. Moreover, the antibacterial effect of the ZOUSH ointment was identical to that of polymyxine B (300 µg).
            Conclusion: We demonstrated that the ZOUSH ointment has inhibitory effects against P. aerugionosa. The inhibition zone diameter is directly correlated with the concentration of the extracts. Our results suggest that the ointment could be useful for treatment of burn wounds and skin infections.
Full-Text [PDF 602 kb]   (664 Downloads)    
Type of Study: Original Paper |
Received: 2018/11/24 | Accepted: 2018/11/24 | Published: 2018/11/24 | ePublished: 2018/11/24

1. Van Delden C, Iglewski BH. Cell-to-cell signaling and Pseudomonas aeruginosa infections. Emerg Infect Dis. 1998; 4(4): 551-60. DOI:10.3201/eid0404.980405. [DOI:10.3201/eid0404.980405]
2. Cobb LM, Mychaleckyj JC, Wozniak DJ, López-Boado YS. Pseudomonas aeruginosa flagellin and alginate elicit very distinct gene expression patterns in airway epithelial cells: implications for cystic fibrosis disease. J Immunol. 2004; 173(9): 5659-5670. [DOI:10.4049/jimmunol.173.9.5659]
3. Sadikot RT, Blackwell TS, Christman JW, Prince AS. Pathogen-host interactions in Pseudomonas aeruginosa pneumonia. Am J Respir Crit Care Med 2005; 171(11):1209-1223. [DOI:10.1164/rccm.200408-1044SO]
4. Holder IA. Pseudomonas immunotherapy: A historical overview. Vaccine. 2004; 22(7):831-839. DOI:10.1016/j.vaccine.2003.11.028. [DOI:10.1016/j.vaccine.2003.11.028]
5. Sadikot RT, Blackwell TS, Christman JW, Prince AS. Pathogen–host interactions in Pseudomonas aeruginosa pneumonia. Am J Respir Crit Care Med. 2005; 171(11): 1209-23. [DOI:10.1164/rccm.200408-1044SO]
6. Wurtz R, Karajovic M, Dacumos E, Jovanovic B, Hanumadass M. Nosocomial infection in a burn intensive care unit. Burns. 1995; 21(3): 181-184. [DOI:10.1016/0305-4179(95)80005-9]
7. Hosseini SMJ, Shoaee NN, Azad Khaledi AC, Daymad F, Esmaeili D. Evaluate the Relationship Between Class 1 Integrons and Drug Resistance Genes in Clinical Isolates of Pseudomonas aeruginosa. Open Microbiol J. 2016; 10: 188-196. [DOI:10.2174/1874285801610010188]
8. Soltani K, Zand R, Mirghasemi A. Epidemiology and mortality of burns inTehran, Iran. Burns. 1998; 24(4): 325-328. [DOI:10.1016/S0305-4179(98)00017-5]
9. Esmaeili D, Moradi F, Foladi AI, Bahador A. The Study of Inhibitory Effects of Satureja khuzestanicaEssence against Exos Gene of MDR Pseudomonas aeruginosa by RT-PCR Technique. Pharmaceut Reg Affairs. 2015; 4: 3.
10. Meskini M, Ghorbanalizadegan M, Esmaeili D. Importance of Herbal Ointment for Pseudomonas aeruginosa infection in burn patients. Int J Med Invest. 2015; 4(2): 257-261.
11. Lotfi N, Shokohi T. A review on fungal infection in burn patients, diagnosis and treatment. J Mazandaran Univ Med Sci. 2014; 23(108): 151-165
12. Yousefi E, Rafienia M, Fazeli H, Kasai MZ. In-Vitro Effects of Copper Nanoparticles on Common Bacterial Strains Implicated in Nosocomial Infections. Journal of Isfahan Medical School. 2013; 31(240):830-842.
13. Alaghebandan R, Rossignol AM, Rastegar Lari A. Pediatric Burn Injuries in Tehran, Iran. Burns. 2001; 27(2): 115-118. [DOI:10.1016/S0305-4179(00)00083-8]
14. Darvishpour A, Lotfi M, Salehi F, Aghazadeh A, Hasani A, Ali N. Comparing Dressing With Silver Sulfadiazine and Nitrofurazone to the Pediatrice Ward in Tabriz. J of Guilan Univer of Med Science. 2006; 15(60): 42-46.
15. Yavarpour V, Zarabi M, Esmaeili D, Mohamadnejad J. In vitro Evaluation of Antibacterial Efficacy of Natural Honeys in Comparison with Antibiotics on Pseudomonas aeruginosa. Iran J Med Microbiol 2014, 8(1): 34-37.
16. Dorman H, Deans S. Antimicrobial agents from plants: antibacterial activity of plant volatile oils. J Appl Microbiol. 2000; 88(2): 308-316. [DOI:10.1046/j.1365-2672.2000.00969.x]
17. Farzaneh M, Kiani H, Sharifi R, Reisi M, Hadian J. Chemical composition and antifungal effects of three species of Satureja (S. hortensis, S. spicigera, and S. khuzistanica) essential oils on the main pathogens of strawberry fruit. Postharvest Biology and Technology. 2015; 109: 145-151. [DOI:10.1016/j.postharvbio.2015.06.014]
18. Abbasi A, Bahador A, Esmaeili D, Mahbubi A, Amiri M, Amiri M. The Study of Inhibitory Effects of Satureja khuzestanica against MDR Isolates of Pseudomonas aeruginosa. International J of Current Microbiology and Applied Sciences. 2014; 2(3):614-618.
19. Moghim H, Taghipoor S, Shahinfard N, Kheiri S, Panahi R. Antifungal effects of Zataria multifora and Nigella sativa extracts against Candida albicans. J HerbMed Pharmacol. 2015; 4(4):138-141.
20. Kavoosi G, Rabiei F. Zataria multiflora: chemical and biological diversity in the essential oil. Journal of Essential Oil Research. 2015; 27(5): 428-436. [DOI:10.1080/10412905.2015.1031917]

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