Volume 13, Issue 5 (Sep-Oct 2019)                   mljgoums 2019, 13(5): 8-12 | Back to browse issues page

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Zare Ebrahimabad M, Teymoori H, Joshaghani H. Vitamin D Status and its Relationship with Thyroid Function Parameters in Patients with Hypothyroidism. mljgoums. 2019; 13 (5) :8-12
URL: http://mlj.goums.ac.ir/article-1-1101-en.html
1- Department of Biochemistry and Biophysics, Metabolic Disorders Research Center, Gorgan Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
2- Laboratory Sciences Research Center (LSRC), Golestan University of Medical Sciences, Gorgan, Iran , hr_joshaghani@yahoo.com
Abstract:   (2783 Views)
            Background and Objectives: Vitamin D is an essential secosteroid that plays a crucial role in the homeostasis of a few mineral elements, particularly calcium. Since vitamin D deficiency and thyroid diseases are two important global health problems, we aimed to investigate a possible relationship of vitamin D and calcium levels with hypothyroidism in an Iranian population.
            Methods: This case-control study was conducted on 175 subjects with hypothyroidism (75 males and 100 females) and 175 euthyroid controls (85 males and 90 females) who were referred to a laboratory in Gorgan, Iran. Serum levels of 25-hydroxyvitamin D, calcium, thyroid-stimulating hormone (TSH), free triiodothyronine (free T3) and thyroxine (total T4) were measured in all participants.
            Results: Vitamin D and calcium were significantly lower in patients with hypothyroidism (P<0.0001). Free T3 and calcium levels differed significantly among hypothyroid patients based on their vitamin D status (P<0.0001), but vitamin D levels were within sufficient range in all groups. Moreover, there was a positive correlation between free T3 with vitamin D (r= 0.337, P<0.0001) and calcium (r= 0.361, P<0.0001) levels.
            Conclusions: Our results suggest that there may be a relationship between decreased vitamin D levels and thyroid function parameters.
            Keywords: Vitamin D Deficiency, Hypocalcemia, Hypothyroidism, Thyrotropin, Thyroxine.
Full-Text [PDF 776 kb]   (458 Downloads)    
Type of Study: Original Paper |
Received: 2018/06/30 | Accepted: 2018/06/30 | Published: 2018/06/30 | ePublished: 2018/06/30

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