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mljgoums 2018, 12(3): 30-33 |
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kheiri S, nematollahi Z, Gholipour N, Asadi J. Lack of Association of SP110 Gene Polymorphisms with Pulmonary Tuberculosis in Golestan Province, Iran. mljgoums 2018; 12 (3) :30-33
URL: http://mlj.goums.ac.ir/article-1-1077-en.html
URL: http://mlj.goums.ac.ir/article-1-1077-en.html
1- Department of Medical Biotechnology, Faculty Of Advanced Medical Technologeis, Golestan University Of Medical Science, Gorgan, Iran
2- Metabolic Disorders Research Center, Golestan University of Medical Science, Gorgan, Iran
3- Student Of National Institute Of Genetic Engineering and Biotechnology , Tehran, Iran
4- Metabolic Disorders Research center, Golestan University of Medical Science, Gorgan, Iran
2- Metabolic Disorders Research Center, Golestan University of Medical Science, Gorgan, Iran
3- Student Of National Institute Of Genetic Engineering and Biotechnology , Tehran, Iran
4- Metabolic Disorders Research center, Golestan University of Medical Science, Gorgan, Iran
Abstract: (14848 Views)
ABSTRACT
Background and Objectives: Mycobacterium tuberculosis is the causative agent of pulmonary tuberculosis, a main public health problem that results in 1.5 million deaths annually. A number of epidemiological studies suggested that host genetic factors could play a main role in susceptibility to tuberculosis infection.
SP110 is an interferon-induced nuclear body protein with vital roles in apoptosis, cell cycling and immunity. SP110 gene has been suggested to be a suitable candidate for limiting TB infections. Thus, we investigated the possible association between SP110 gene polymorphisms and susceptibility to tuberculosis in the Golestan Province, Iran.
Methods: We investigated the frequency of rs1135791 polymorphism of the SP110 gene among 100 pulmonary tuberculosis patients and 100 healthy individuals who were referred to the health centers in the Golestan Province (Iran) between 2014 and 2015. Frequency of genotypes was evaluated using amplification refractory mutation system-polymerase chain reaction.
Results: The frequency distribution of TT, TC and CC genotypes among the patients was 65%, 31% and 4%, respectively. In the control group, the frequency distribution of TT, TC and CC genotypes was 56%, 46% and 7%, respectively. There was no significant difference in the frequency of rs1135791 between the patients with pulmonary tuberculosis and the healthy controls (P=0.42).
Conclusion: Based on the results, the SP110 rs1135791 variant is not a genetic risk factor for development of pulmonary tuberculosis in Golestan Province, Iran.
Keywords: rs1135791T, Pulmonary tuberculosis, Golestan Province.
Background and Objectives: Mycobacterium tuberculosis is the causative agent of pulmonary tuberculosis, a main public health problem that results in 1.5 million deaths annually. A number of epidemiological studies suggested that host genetic factors could play a main role in susceptibility to tuberculosis infection.
SP110 is an interferon-induced nuclear body protein with vital roles in apoptosis, cell cycling and immunity. SP110 gene has been suggested to be a suitable candidate for limiting TB infections. Thus, we investigated the possible association between SP110 gene polymorphisms and susceptibility to tuberculosis in the Golestan Province, Iran.
Methods: We investigated the frequency of rs1135791 polymorphism of the SP110 gene among 100 pulmonary tuberculosis patients and 100 healthy individuals who were referred to the health centers in the Golestan Province (Iran) between 2014 and 2015. Frequency of genotypes was evaluated using amplification refractory mutation system-polymerase chain reaction.
Results: The frequency distribution of TT, TC and CC genotypes among the patients was 65%, 31% and 4%, respectively. In the control group, the frequency distribution of TT, TC and CC genotypes was 56%, 46% and 7%, respectively. There was no significant difference in the frequency of rs1135791 between the patients with pulmonary tuberculosis and the healthy controls (P=0.42).
Conclusion: Based on the results, the SP110 rs1135791 variant is not a genetic risk factor for development of pulmonary tuberculosis in Golestan Province, Iran.
Keywords: rs1135791T, Pulmonary tuberculosis, Golestan Province.
Research Article: Original Paper |
Received: 2018/04/30 | Accepted: 2018/04/30 | Published: 2018/04/30 | ePublished: 2018/04/30
Received: 2018/04/30 | Accepted: 2018/04/30 | Published: 2018/04/30 | ePublished: 2018/04/30
References
1. WHO. Global tuberculosis report. 2012. World Health Organization. ISBN 9789241564502.
2. Zumla A, George A, Sharma V, Herbert N, Baroness Masham of Ilton. WHO's 2013 global report on tuberculosis: successes, threats, and opportunities. Lancet. 2013; 382(9907): 1765-7. doi: 10.1016/S0140-6736(13)62078-4. [DOI:10.1016/S0140-6736(13)62078-4]
3. Png E, Alisjahbana B, Sahiratmadja E, Marzuki S, Nelwan R, Adnan I, et al. Polymorphisms in SP110 are not associated with pulmonary tuberculosis in Indonesians. Infect Genet Evol. 2012; 12(6): 1319-23. doi: 10.1016/j.meegid.2012.04.006. [DOI:10.1016/j.meegid.2012.04.006]
4. Qu HQ, Fisher-Hoch SP, McCormick JB. Knowledge gaining by human genetic studies on tuberculosis susceptibility. J Hum Genet. 2011; 56(3): 177-82. doi: 10.1038/jhg.2010.164. [DOI:10.1038/jhg.2010.164]
5. Pan H, Yan BS, Rojas M, Shebzukhov YV, Zhou H, Kobzik L, et al. Ipr1 gene mediates innate immunity to tuberculosis. Nature. 2005; 434(7034): 767-72. [DOI:10.1038/nature03419]
6. Bloch DB, Nakajima A, Gulick T, Chiche JD, Orth D, de La Monte SM,et al. Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivator. Mol Cell Biol. 2000; 20: 6138-46.
7. Fox GJ, Sy DN, Nhung NV, Yu B, Ellis MK, Van Hung N, et al. Polymorphisms of SP110 are associated with both pulmonary and extra-pulmonary tuberculosis among the Vietnamese. PloS one. 2014; 9(7): e99496.
8. Tosh K, Campbell SJ, Fielding K, Sillah J, Bah B, Gustafson P, et al. Variants in the SP110 gene are associated with genetic susceptibility to tuberculosis in West Africa. Proc Natl Acad Sci U S A. 2006; 103(27): 10364-10368. doi: 10.1073/pnas.0603340103. [DOI:10.1073/pnas.0603340103]
9. Abhimanyu, Jha P, Jain A, Arora K, Bose M. Genetic association study Suggests a role for SP110 variants in lymph node tuberculosis but not pulmonary tuberculosis in north Indians. Hum Immunol. 2011; 72(7): 576-80. doi: 10.1016/j.humimm.2011.03.014..
10. Liang L, Zhao YL, Yue J, Liu JF, Han M, Wang H, et al. Association of SP110 gene polymorphisms with susceptibility to tuberculosis in a Chinese population. Infect Genet Evol. 2011; 11(5): 934-9. doi: 10.1016/j.meegid.2011.02.017. [DOI:10.1016/j.meegid.2011.02.017]
11. Lei X, Zhu H, Zha L, Wang Y. SP110 gene polymorphisms and tuberculosis susceptibility: A systematic review and meta-analysis based on 10624 subjects. Infect Genet Evol. 2012; 12(7): 1473-80. doi: 10.1016/j.meegid.2012.05.011. [DOI:10.1016/j.meegid.2012.05.011]
12. Nicewonger J, Suck G, Bloch D, Swaminathan S. Epstein-Barr virus (EBV) SM protein induces and recruits cellular Sp110b to stabilize mRNAs and enhance EBV lytic gene expression. J Virol. 2004; 78(17): 9412-22.
13. Regad T, Chelbi-Alix MK. Role and fate of PML nuclear bodies in response to interferon and viral infections. Oncogene. 2001; 20(49): 7274-86. [DOI:10.1038/sj.onc.1204854]
14. Abhimanyu, Jha P, Jain A, Arora K, Bose M. Genetic association study suggests a role for SP110 variants in lymph node tuberculosis but not pulmonary tuberculosis in north Indians. Hum Immunol. 2011; 72(7): 576-80. doi: 10.1016/j.humimm.2011.03.014. [DOI:10.1016/j.humimm.2011.03.014]
15. Babb C, Keet EH, van Helden PD, Hoal EG. SP110 polymorphisms are not associated with pulmonary tuberculosis in a South African population. Hum Genet. 2007; 121(3-4): 521-2.
16. Szeszko JS, Healy B, Stevens H, Balabanova Y, Drobniewski F, Todd JA, et al. Resequencing and association analysis of the SP110 gene in adult pulmonary tuberculosis. Hum Genet. 2007; 121(2): 155-60.
17. Thye T, Browne EN, Chinbuah MA, Gyapong J, Osei I, Owusu-Dabo E, et al. No associations of human pulmonary tuberculosis with Sp110 variants. J Med Genet. 2006; 43(7): e32.
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