Medical Laboratory Journal
Medical Laboratory Journal
mljgoums
Medical Sciences
http://mlj.goums.ac.ir
1
admin
2538-4449
10.52547/mlj
en
jalali
1388
1
1
gregorian
2009
4
1
3
1
online
1
fulltext
fa
مولکولار اپیدمیولوژی پاپیلوماویروس انسانی و انواع پرخطر آن(HPV-16, ( 18 در بافت سرطانی پستان به روشPCR در استان گلستان
Molecular epidemiology of Human Papillomaviruses in breast cancer, Golestan province of Iran
Abstract Background and objectives: Breast cancer is the most prevalent one in women. Some of the common causative factors are genetic background, nutritional and environmental factors. Viruses are believed as a risk factor in this cancer, too. Recent studies reported that Human Papillomaviruses can be one of the possible risk factors of breast cancer. This study focused on investigation of the papillomavirus genome in tissues of breast cancer in Golestan province, Iran. Material and Methods: This descriptive analytical study was done from 2005 until 2008. The Samples were obtained from women admitted to the hospitals in Gorgan and Gonbad cities. All breast biopsy or mastectomy tissues were confirmed by the pathologists for breast cancer. DNA was extracted and PCR done by using general primers (GP5 + / GP6 + and MY09/MY11) for detection of papillomavirus genomes. Results: The Subjects are 231 patients aged 47± 12/72, the youngest 20 and the oldest 84. They are from Gorgan (N=122)and Gonbad (N=109) The result Shows That The Subjects Suffer from infiltrating ductular Carcinoma(31.4%), infiltrating duct Carcinoma (60.1%)and intraductal Lobular Carcinoma (4.3%) and The rest from other kinds of Cancer. Papilloma Virus genome is not found in These Samples. Conclusion: Based on paradoxical results from different parts of the world, upon the presence or absence of papillomavirus genome in breast cancer samples, to show the role of this virus in the development of breast cancer more studies are needed. Key words: Breast Cancer, Papillomaviruses, Golestan Province
Key words: Breast Cancer, Papillomaviruses, Golestan Province
0
0
http://mlj.goums.ac.ir/browse.php?a_code=A-10-1-29&slc_lang=fa&sid=1
A
Moradi
عبدالوهاب
مرادی
abmoradi@ yahoo.com
100319475328460013157
100319475328460013157
Yes
Associate professor, Microbiology
دانشگاه علوم پزشکی گلستان،دانشکده پزشکی ،گروه میکروبولوژی
E
Mobasheri
الهام
مبشری
100319475328460013158
100319475328460013158
No
دانشگاه علوم پزشکی گلستان
A
Tabarraei
علیجان
تبرائی
100319475328460013159
100319475328460013159
No
دانشگاه علوم پزشکی گلستان
S
Bakhshandeh Nosrat
سپیده
بخشنده نصرت
100319475328460013160
100319475328460013160
No
مرکز تحقیقات عفونی ، دانشگاه علوم پزشکی گلستان
V
Kazemi nejad
وحیده
کاظمی نژاد
100319475328460013161
100319475328460013161
No
-مرکز تحقیقات عفونی دانشگاه علوم پزشکی گلستان
R
Azarhosh
رامین
آذرهوش
100319475328460013162
100319475328460013162
No
دانشگاه علوم پزشکی گلستان
SH
Alizadeh
شهریار
علیزاده
100319475328460013163
100319475328460013163
No
M
Bazori
مسعود
بازوری
100319475328460013164
100319475328460013164
No
دانشگاه علوم پزشکی گلستان