en علوم آزمایشگاهی Laboratory Sciences Research Article Research Article <div style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:Times New Roman;"><b>Background:</b> Menopause, characterized by the cessation of menstrual periods, often leads to bone diseases due to hormonal changes, particularly affecting calcium metabolism. This study aimed to evaluate bone-associated biomarkers and their correlation with parathyroid hormone (PTH) levels in postmenopausal women, shedding light on potential osteoporosis risks.<br> <b>Methods:</b> Sixty postmenopausal (PMP) women, along with 20 premenopausal (PRM) and 20 reproductive-age (RWA) women as controls, were included in this cross-sectional study. Blood samples were analyzed for PTH, vitamin D, uric acid, calcium, phosphorus, alkaline phosphatase (ALP), and estradiol levels.<br> <b>Results:</b> Statistical analysis revealed significantly higher levels of ALP and phosphorus, and lower levels of calcium, PTH, vitamin D, uric acid, and estradiol in PMP and PRM groups compared to RWA (p <0.05). Moreover, PTH had a significant negative correlation with ALP, and phosphorus; however, it had a positive correlation with calcium, vitamin D, and estradiol in PMP women. ALP demonstrated a superior area under the receiver operating characteristic curve (AUC-ROC) compared to other bone-associated markers.<br> <b>Conclusion</b>: These findings highlight the reduced bone-associated biomarker levels in postmenopausal women, potentially increasing the risk of bone loss and osteoporosis.</span></span><br> &nbsp;</div> Osteoporosis, Post menopause, Hyperparathyroidism, Bone density, Vitamin D 9 13 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1751-1&slc_lang=en&sid=1 Atere Adedeji David adedeji.atere@uniosun.edu.ng 100319475328460030725 100319475328460030725 Yes Department of Medical Laboratory Science, Faculty of Basic Medical Sciences, Osun State University, Osogbo, Osun State, Nigeria; Department of Medical Laboratory Science, Achievers University, Owo, Ondo State, Nigeria Ehuine Elizabeth Efe elizabethehuine@gmail.com 100319475328460030726 0009-0005-9532-9670 No Department of Medical Laboratory Science, Achievers University, Owo, Ondo State, Nigeria Kosamat Yekeen Adebisi yekeen.kosamat@uniosun.edu.ng 100319475328460030727 0009-0005-2482-0374 No Department of Medical Laboratory Science, Faculty of Basic Medical Sciences, Osun State University, Osogbo, Osun State, Nigeria Ige Ilesanmi Paul sanmi2sure@gmail.com 100319475328460030728 100319475328460030728 No Department of Medical Laboratory Science, Achievers University, Owo, Ondo State, Nigeria