en آسيب شناسي Pathology Research Article Research Article <div style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:Times New Roman;"><b>Background:</b> Pregnancy-induced hypertension (PIH) is a multi-system disorder affecting 6-8% of pregnancies in the U.S. and contributing significantly to maternal mortality, accounting for 16% in developed countries. It progresses from preeclampsia to eclampsia, leading to multi-organ damage through mechanisms such as oxidative stress, placental ischemia, and endothelial dysfunction. While the exact pathogenesis remains unclear, genetic, immunologic, and environmental factors are implicated. The American College of Obstetricians and Gynecology (ACOG) recommends initiating treatment when diastolic blood pressure exceeds 105-110 mmHg.<br> <b>Methods:</b> This narrative review examines existing literature on PIH, including epidemiological data, pathophysiological mechanisms, clinical management guidelines, and associated complications such as abnormal placentation, oxidative stress, and endothelial dysfunction.<br> <b>Results:</b> This study demonstrates that hypertensive disorders of pregnancy (HDP) significantly impact maternal and fetal health, particularly in developing countries with limited healthcare access. Early detection and continuous monitoring play a key role in reducing complications. Additionally, HDP is associated with increased long-term cardiovascular and metabolic risks, highlighting the importance of postpartum follow-up.<br> <b>Conclusion</b>: HDP poses a serious threat to maternal and fetal health, with potential long-term consequences. Effective management requires early diagnosis, close monitoring, and postpartum follow-up. Global implementation of risk assessment and targeted care strategies can help reduce the burden of this condition. Strengthening healthcare systems and increasing awareness among healthcare providers and patients are essential steps toward improving outcomes.</span></span></div> Eclampsia, Placenta, Pre-Eclampsia, Hypertension, Pregnancy-Induced 9 16 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1732-1&slc_lang=en&sid=1 Adedeji Okikiade okikis@yahoo.com 100319475328460030469 100319475328460030469 Yes Department of Pathology, College of Clinical Sciences, California Northstate University, Elk Grove, California, United States of America; Ejyde International Education and Research Consultancy, Maryland, United States of America Chidinma Kanu judith_kanu@yahoo.com 100319475328460030470 100319475328460030470 No Ejyde International Education and Research Consultancy, Maryland, United States of America Oluwadamilare Iyapo darray2001@yahoo.com 100319475328460030471 100319475328460030471 No Department of Pathology, Eko University of Medicine and Health Sciences, Lagos, Nigeria Ololade Omitogun loladeakinfegbe@yahoo.com 100319475328460030472 100319475328460030472 No Director, Alluring Healthcare Solutions Limited Liability Company (L.L.C), Maryland, United States of America