Medical Laboratory Journal

en Correlation of Diagnostic Yield with Laboratory Parameters and Histopathological Examination in Clinically Suspected Cases of Mucormycosis in Post-COVID-19 Patients: A Single-Center Study in Ahmedabad, India قارچ شناسی Mycology تحقيقي Original Paper <div style="text-align: justify;">Background: Mucormycosis is a complication in post-coronavirus disease 2019 (COVID-19) patients in India. This study was done to evaluate the prognostic value of clinical, histopathologic findings, microbiological features, and biochemical parameters such as D-dimer, lactate dehydrogenase, and serum ferritin in post- COVID-19-patients with rhino-orbital mucormycosis. Methods: This retrospective observational study was carried out on biopsies taken from 50 post-COVID-19 patients suspected of mucormycosis. The biopsy specimens were processed and stained with hematoxylin and eosin, periodic acid–schiff, and Wright-Giemsa. In addition, 10–20% potassium hydroxide wet mount and culture on sabouraud dextrose agar were performed to detect Mucor. The biochemical parameters were measured using ARCHITECT ci8200 chemistry analyzer. Results: Overall, 30 cases (60%) were positive for fungal elements, and growth of Mucor spp. was found in 28 cases (56%). In histopathology, 70% of cases (n=35) showed broad, aseptate, ribbon-like hyphae with wide-angled branching diagnostic of mucormycosis. There seemed to be a site-wise overlap between the nasal/maxillary sinus and rhino-orbital/rhino-cerebral variety. There was no difference between the patients in terms of gender. The most common risk factor was diabetes mellitus (observed in 80% of cases). In patients with invasive mucormycosis, inflammatory biomarkers such as serum ferritin, serum lactate dehydrogenase, C-reactive protein, and D-dimer were greater than the normal range, whereas procalcitonin was within the reference range.    Conclusion: It can be concluded that raised metabolic markers, direct 10% KOH examination and histological features including angioinvasion as well as rhino-orbital and cerebral extension might assist doctors in diagnosis, progression, and survival rate.</div> COVID-19,Mucormycosis,Biomarkers, 1 7 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1309-1&slc_lang=en&sid=1 Usha Patel ushapatel2002@gmail.com 100319475328460031983 100319475328460031983 Yes Dept of Biochemistry, AMC MET Medical College, L.G Hospital- Gujrat University, Maninagar, Ahmedabad-380008, Gujarat, India Nanda Jagrit jagritnanda34@gmail.com 100319475328460031984 100319475328460031984 No Dept of Pathology, AMC MET Medical College, L.G Hospital- Gujarat University, Maninagar, Ahmedabad-380008, Gujarat, India Toral Bhavsar toralbhavsar@hotmail.com 100319475328460031985 100319475328460031985 No Dept of Microbiology, AMC MET Medical College, L.G Hospital- Gujarat University, Maninagar, Ahmedabad-380008, Gujarat, India Shubham Panchal shubhamp007@yahoo.in 100319475328460031986 100319475328460031986 No Dept of Pathology, AMC MET Medical College, L.G Hospital- Gujarat University, Maninagar, Ahmedabad-380008, Gujarat, India Krutina Parikh krutina.parikh@gmail.com 100319475328460031987 100319475328460031987 No Dept of Pathology, AMC MET Medical College, L.G Hospital- Gujarat University, Maninagar, Ahmedabad-380008, Gujarat, India Himanshu Nayak drhknayak@yahoo.com 100319475328460031988 100319475328460031988 No ept of Preventive and social medicine, AMC MET Medical College, L.G Hospital- Gujarat University, Maninagar, Ahmedabad-380008, Gujarat, India