Medical Laboratory Journal
Medical Laboratory Journal
mljgoums
Medical Sciences
http://mlj.goums.ac.ir
1
admin
2538-4449
10.52547/mlj
en
jalali
1401
12
1
gregorian
2023
3
1
17
2
online
1
fulltext
en
Histopathological Evaluation of Granulomatous Skin Lesions: A Study from North India
آسيب شناسي
Pathology
Research Article
Research Article
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""><b>Background and objectives:</b> Granulomatous<b> </b>disorders of the skin are frequently encountered in clinical practice and require histopathological confirmation due to a considerable etiological and clinical overlap. A single histopathological pattern may be produced by many causative agents and at the same time, a single cause can present with varied histopathological patterns. The present study was performed to evaluate the histomorphological patterns of granulomas in various granulomatous skin lesions and to identify the causative agents.</span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""><b>Methods:</b> The study (both prospective and retrospective) was carried out in the department of pathology over 5 years. All skin biopsies were evaluated for the presence of granulomas. Detailed analysis of the histopathological pattern of granulomas was performed and categorization was made according to the type and etiology. Special stains were also used when required. A clinicopathological correlation was established with <span style="background:white"><span style="color:black">the Kappa statistic. </span></span><span style="background:white"></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""><b>Results:</b> Of 1,150 skin biopsies, granulomatous skin lesions were observed in 325 cases. Histiocytic granuloma pattern was the most common subtype (55.7%). The predominant etiology of granulomatous inflammation was leprosy (93.5%), followed by cutaneous tuberculosis (2.7%). The cases of Hansen’s disease showed a maximum clinicopathological correlation (58.5%).</span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""><b>Conclusion:</b> <span style="background:white"><span style="color:black">Histopathological examination is the gold standard for the diagnosis and subtyping of granulomatous skin lesions. Varied morphologies of granuloma patterns were observed in our study, and i</span></span>nfectious diseases were the causative agents in the majority of cutaneous granulomatous disorders. </span></span></span></span>
Granuloma,Leprosy,Tuberculosis,
7
13
http://mlj.goums.ac.ir/browse.php?a_code=A-10-1278-1&slc_lang=en&sid=1
Priyanka
Sharma
rahulukraine@gmail.com
100319475328460023969
100319475328460023969
No
Department of Pathology, Government Medical College, Jammu, India
Rahul
Verma
rahulsrhu@gmail.com
100319475328460023970
100319475328460023970
Yes
Department of Pathology, AIIMS Rishikesh, India