en قارچ شناسی Mycology مروري Review Article <span style="font-size:11pt"><span style="line-height:200%"><span style="tab-stops:-22.5pt 13.5pt"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">Background and objectives:</span></span></span></b><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""> Mycotic keratitis is a fungal infection of the cornea that can cause blindness. Its </span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">incidence, risk factors, and the etiological agents vary worldwide and nationwide. Therefore, proper documentation of these data is essential for better disease management. In this review, we aimed to make a clear picture of this infection in the Middle East.</span></span></span><b><span style="font-size:12.0pt"><span style="line-height:200%"><span style="font-family:"Times New Roman","serif""></span></span></span></b></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:200%"><span style="tab-stops:-22.5pt 13.5pt"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">Methods:</span></span></span></b><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""> Data on fungal keratitis from 1986 to 2018 in the Middle East were systematically collected from five English databases (PubMed, Scopus, Science Direct, Web of Science, and Google Scholar) and four Persian databases (Magiran, Scientific Information Database, IranMedex, and Irandoc). A total of 35 studies were included in the review. </span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:200%"><span style="tab-stops:-22.5pt 13.5pt"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">Result:</span></span></span></b><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""> The pooled prevalence of fungal keratitis in the Middle East was estimated at </span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">26</span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">% (</span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">95% confidence interval: 19-32%; </span></span></span><m:omath><m:ssup><m:ssuppr><span style="font-size:12.0pt"><span cambria="" math="" style="font-family:"><m:ctrlpr></m:ctrlpr></span></span></m:ssuppr><m:e><span style="font-size:12.0pt"><span style="line-height:200%"><span cambria="" math="" style="font-family:"><m:r><m:rpr><m:scr m:val="roman"><m:sty m:val="p"></m:sty></m:scr></m:rpr>I</m:r></span></span></span></m:e><m:sup><span style="font-size:12.0pt"><span style="line-height:200%"><span cambria="" math="" style="font-family:"><m:r><m:rpr><m:scr m:val="roman"><m:sty m:val="p"></m:sty></m:scr></m:rpr>2</m:r></span></span></span></m:sup></m:ssup><span style="font-size:12.0pt"><span style="line-height:200%"><span cambria="" math="" style="font-family:"><m:r><m:rpr><m:scr m:val="roman"><m:sty m:val="p"></m:sty></m:scr></m:rpr>=98.88%, </m:r><m:r><i>p</i></m:r><m:r><i><</i></m:r><m:r><m:rpr><m:scr m:val="roman"><m:sty m:val="p"></m:sty></m:scr></m:rpr>0.001)</m:r></span></span></span></m:omath><span style="font-size:11.0pt"><span style="line-height:115%"><span calibri="" style="font-family:"><span style="position:relative"><span style="top:5.5pt"> </span></span></span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">&nbsp;using random-effect model, with considerable variation among the countries. The prevalence of fungal keratitis was highest in Egypt (36%) and Iran (34%) and lowest in Oman (9%). <i>Aspergillus</i> and <i>Fusarium</i> spp. were the most common causative agents (28%) among filamentous fungi, and </span></span></span><i><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">Candida</span></span></span></i><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""> (13%) was the predominant yeast </span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">species causing fungal keratitis. Based on the data, fungal keratitis was more prevalent in males (39%) than in females (23%).</span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:200%"><span style="tab-stops:-22.5pt 13.5pt"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></span></b><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""> Our study is the first systematic review on mycotic keratitis among the Middle Eastern countries. These epidemiological estimates can be used by policy makers to improve treatment strategies, especially in this part of the world.</span></span></span><b><span style="font-size:12.0pt"><span style="line-height:200%"><span style="font-family:"Times New Roman","serif""></span></span></span></b></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:200%"><span style="tab-stops:-22.5pt 13.5pt"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">Background and objectives:</span></span></span></b><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""> Mycotic keratitis is a fungal infection of the cornea that can cause blindness. Its </span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">incidence, risk factors, and the etiological agents vary worldwide and nationwide. Therefore, proper documentation of these data is essential for better disease management. In this review, we aimed to make a clear picture of this infection in the Middle East.</span></span></span><b><span style="font-size:12.0pt"><span style="line-height:200%"><span style="font-family:"Times New Roman","serif""></span></span></span></b></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:200%"><span style="tab-stops:-22.5pt 13.5pt"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">Methods:</span></span></span></b><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""> Data on fungal keratitis from 1986 to 2018 in the Middle East were systematically collected from five English databases (PubMed, Scopus, Science Direct, Web of Science, and Google Scholar) and four Persian databases (Magiran, Scientific Information Database, IranMedex, and Irandoc). A total of 35 studies were included in the review. </span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:200%"><span style="tab-stops:-22.5pt 13.5pt"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">Result:</span></span></span></b><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""> The pooled prevalence of fungal keratitis in the Middle East was estimated at </span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">26</span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">% (</span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">95% confidence interval: 19-32%; </span></span></span><m:omath><m:ssup><m:ssuppr><span style="font-size:12.0pt"><span cambria="" math="" style="font-family:"><m:ctrlpr></m:ctrlpr></span></span></m:ssuppr><m:e><span style="font-size:12.0pt"><span style="line-height:200%"><span cambria="" math="" style="font-family:"><m:r><m:rpr><m:scr m:val="roman"><m:sty m:val="p"></m:sty></m:scr></m:rpr>I</m:r></span></span></span></m:e><m:sup><span style="font-size:12.0pt"><span style="line-height:200%"><span cambria="" math="" style="font-family:"><m:r><m:rpr><m:scr m:val="roman"><m:sty m:val="p"></m:sty></m:scr></m:rpr>2</m:r></span></span></span></m:sup></m:ssup><span style="font-size:12.0pt"><span style="line-height:200%"><span cambria="" math="" style="font-family:"><m:r><m:rpr><m:scr m:val="roman"><m:sty m:val="p"></m:sty></m:scr></m:rpr>=98.88%, </m:r><m:r><i>p</i></m:r><m:r><i><</i></m:r><m:r><m:rpr><m:scr m:val="roman"><m:sty m:val="p"></m:sty></m:scr></m:rpr>0.001)</m:r></span></span></span></m:omath><span style="font-size:11.0pt"><span style="line-height:115%"><span calibri="" style="font-family:"><span style="position:relative"><span style="top:5.5pt"> </span></span></span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">&nbsp;using random-effect model, with considerable variation among the countries. The prevalence of fungal keratitis was highest in Egypt (36%) and Iran (34%) and lowest in Oman (9%). <i>Aspergillus</i> and <i>Fusarium</i> spp. were the most common causative agents (28%) among filamentous fungi, and </span></span></span><i><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">Candida</span></span></span></i><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""> (13%) was the predominant yeast </span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">species causing fungal keratitis. Based on the data, fungal keratitis was more prevalent in males (39%) than in females (23%).</span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:200%"><span style="tab-stops:-22.5pt 13.5pt"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></span></b><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""> Our study is the first systematic review on mycotic keratitis among the Middle Eastern countries. These epidemiological estimates can be used by policy makers to improve treatment strategies, especially in this part of the world.</span></span></span><b><span style="font-size:12.0pt"><span style="line-height:200%"><span style="font-family:"Times New Roman","serif""></span></span></span></b></span></span></span></span></span><br> &nbsp; Egypt,Iran,Systematic Review, 43 51 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1198-1&slc_lang=en&sid=1 mahmoud Karimizadeh Esfahani karimizadehem1@mums.ac.ir 100319475328460026712 100319475328460026712 No Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran mohsen najjari najjarimh@mums.ac.ir 100319475328460026713 100319475328460026713 No Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Saeed Hosseini Teshnizi 100319475328460026714 100319475328460026714 No Food Health Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran Somayeh Dolatabadi somayeh99@gmail.com 100319475328460026715 100319475328460026715 Yes Department of Biology, Hakim Sabzevari University, Sabzevar, Iran mohammad javad najafzadeh javad,najafzadeh@gmail.com 100319475328460026716 100319475328460026716 No Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran