en خون شناسی آزمایشگاهی و بانک خون Laboratory hematology گزارش مورد Case Report <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:200%"><span calibri=""><span style="line-height:200%"><span new="" roman="" times="">Lymphangioma circumscriptum is a rare congenital proliferation of lymphatic vessels that may occur anywhere on the skin and mucous membranes. Based on the depth and the size of abnormal lymph vessels, these lesions are divided into two groups: the superficial vesicles are called lymphangioma circumscriptum and the more deep-seated group includes cavernous lymphangioma, cystic hygroma, and benign lymphangioendothelioma. The differential diagnosis of lymphangioma includes herpes zoster, herpes simplex, molluscum contagiosum, cutaneous melanoma, dermatitis herpetiformis, and viral warts. Herein, we report a rare case of giant cutaneous lymphangioma circumscriptum with emphasis on histopathology and differential diagnosis. Our case was a 14-year-old boy with a history of multiple, clear, pink, red, and brown vesicles protruded as a patch of wart-like growths on the flank&rsquo;s </span></span><a href="https://kidshealth.org/KidsHealthDemo/en/parents/skin-hair-nails.html" style="color:blue; text-decoration:underline"><span style="line-height:200%"><span new="" roman="" times=""><span style="text-decoration:none">skin</span></span></span></a><span style="line-height:200%"><span new="" roman="" times=""> since the 6&nbsp;months of age.</span></span> <span style="line-height:200%"><span new="" roman="" times="">Histopathologic examination indicated presence of multiple thin-walled dilated lymphatic spaces in the papillary dermis lined with a single layer of endothelial cells filled with finely granular hyaline material.</span></span></span></span></span></span><span style="font-size:11pt"><span style="line-height:200%"><span calibri="" style="font-family:"><span style="font-size:12.0pt"><span style="line-height:200%"><span style="font-family:"Times New Roman",serif"></span></span></span></span></span></span> Lymphangioma,Pathology,Skin, 28 29 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1124-1&slc_lang=en&sid=1 Alireza Sobhani researchermedicin@gmail.com 100319475328460031925 100319475328460031925 No Department of Pathology, Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran Hakimeh S. Sajjadi sajjadipathologyh@gmail.com 100319475328460031926 100319475328460031926 Yes Department of Pathology, Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran Touba Abbasi touba.abbasi@gmail.com 100319475328460031927 100319475328460031927 No Department of Pathology, Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran