Medical Laboratory Journal
Medical Laboratory Journal
mljgoums
Medical Sciences
http://mlj.goums.ac.ir
1
admin
2538-4449
10.52547/mlj
en
jalali
1398
4
1
gregorian
2019
7
1
13
4
online
1
fulltext
fa
Investigation of the Possible Association between Human Cytomegalovirus and Pterygium Development
ميکروب شناسي
Microbiology
تحقيقي
Original Paper
<div><strong>ABSTRACT</strong><br>
<strong> Background and Objectives</strong><strong><span dir="RTL">:</span></strong> Pterygium is a common ocular surface lesion that manifest as wing-shaped, benign <a href="http://en.wikipedia.org/wiki/Conjunctiva" title="Conjunctiva">conjunctiva</a>l growth, which can extend onto the corneal surface. Presence of some oncogenic viruses in pterygium and the neoplastic nature of the lesion led us to the postulated involvement of the viruses in the etiology of pterygia. The aim of this study was to evaluate prevalence and possible role of human cytomegalovirus (HCMV) in the formation of pterygia.<br>
<strong>Methods: </strong>Fifty pterygium specimens and 10 normal conjunctival biopsy specimens (controls) were investigated by polymerase chain reaction using primers specific for the highly conserved regions of major capsid protein gene of HCMV. Data were analyzed using SPSS statistical software (IBM SPSS Statistics 18; IBM Corporation, USA) at significance level of 0.05.<span dir="RTL"></span><br>
<strong>Results:</strong> The HCMV DNA was detected in seven (14%) patients with pterygium but in none of the control subjects. All subjects were β-globin positive. <span dir="RTL"></span><br>
<strong> Conclusion: </strong>Given the results, direct involvement of HCMV in the development of pterygium seems less probable, thus suggesting that other agents might be involved in the multistep process of the disease.<br>
<strong> Keywords: </strong>Human Cytomegalovirus, Pterygium, Polymerase Chain Reaction.<span dir="RTL"></span></div>
Human Cytomegalovirus, Pterygium, Polymerase Chain Reaction.
1
4
http://mlj.goums.ac.ir/browse.php?a_code=A-10-623-5&slc_lang=fa&sid=1
Mishar
Kelishadi
100319475328460018832
100319475328460018832
No
Laboratory Sciences Research Center, Golestan University of Medical Science, Gorgan, Iran; and Department of Virology, Pasteur Institute of Iran, Tehran, Iran
Mandana
Kelishadi
100319475328460018833
100319475328460018833
No
Department of Ophthalmology, 5th Azar Hospital, Gorgan, Iran
G.Hossein
Ashrafi
100319475328460018834
100319475328460018834
No
Kingston University London, Cancer Theme, School of Life Science, Pharmacy and Chemistry, SEC Faculty, Kingston upon Thames, KT12EE, London, UK
Alijan
Tabarraei
alijant@yahoo.com
100319475328460018835
100319475328460018835
Yes
Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran