This paper should be cited as: Asghari Estiar,
M. Rafi, A. Heidarzadeh, S. Ohadian
Moghadam, S. Mahboubi, R. Monadi Sefidan, A. Allafzadeh, J. Nik Khah, H.
Antibiotic
Resistance of the Isolated Bacteria from Blood Cultures of Cancer Patients
Asghari Estiar, M. (MSc)1, Rafi, A. (PhD)2.,Heidarzadeh,
S. (PhD)3,Ohadian Moghadam, S. (PhD)4,
Mahboubi, R. (PhD)5, Monadi
Sefidan, A. (PhD)6, Allafzadeh,
J. (BSc)7, Nik Khah,
H. (BSc)8
1. MSc of Laboratory Sciences, Students' Scientific Research Center, School
of Medicine, Tehran University of
Medical Sciences, Tehran, Iran
2. Professor of
Microbiology, Department of Laboratory Sciences, Paramedical School, Tabriz University of Medical Sciences, Tabriz, Iran
3. Assistant Professor of
Microbiology, Department of Pathobiology, School of Public Health, Tehran
University of Medical Sciences, Tehran, Iran
4. Assistant
Professor of Microbiology, Department of Pathobiology, School of Public Health,
Tehran University of Medical Sciences, Tehran, Iran
5. Assistant Professor of
Microbiology, Biotechnology Research Center, Tehran University of Medical
Sciences, Tehran, Iran
6. Assistant Professor of Microbiology,
Department of Laboratory Sciences, Paramedical School, Tehran University of
Medical Sciences, Tehran, Iran
7. BSc of
Laboratory Sciences, Department of Laboratory Sciences, Paramedical School,
Tabriz University of Medical Sciences, Tabriz, Iran
8. BSc of
Laboratory Sciences, Department of Laboratory Sciences, Paramedical School,
Tabriz University of Medical Sciences, Tabriz, Iran
Abstract
Background
and Objective: One of
the main causes of increased mortality in cancer patients is bacteremia. On the
other hand, antibiotic resistance is the major cause of treatment failure in
malignant diseases especially in hematological malignancies. The aim of this
study was to diagnose the bacterial strains isolated from blood specimens of
cancer patients and to determine their antibiotic susceptibility.
Material
and Methods: In
this cross-sectional study, 0.5 ml of venous blood was taken from 613 cancer
patients especially leukemia, and blood cultures and antibiotic susceptibility
tests were performed using standard methods. Using disc diffusion method,
antibiotic susceptibility was performed with a wide range of antibiotics.
Results:
Out of 613 cultured specimens,
153 (25%) were found to be positive including 76.47% of gram negative and
23.53% of gram positive bacteria. The most common isolated bacteria were E.
coli, coagulase-negative Staphylococci, Klebsiella,
Staphylococcus aureus and Pseudomonas aeroginosa, respectively.
Conclusion:
It seems that Ceftriaxone
is the best choice for the
treatment of gram negative caused bacteremia and Gentamicin for bacteremia
caused by gram positive agents. Given the high level of resistance to the
commonly used antibiotics, it seems reasonable to avoid of early and
inappropriate use of antibiotics to prevent the development of drug resistant
bacteria.
Keywords: Cancer, Blood
Cultures, Bacteremia, Antibiotic Resistance
Corresponding Author: Rafi, A.
Email: rafi_dr@yahoo.com
Received: 30
Jul 2013
Revised: 25 Jul 2014
Accepted: 28 Jul 2014