This paper should be cited as: Ghaffari, H. Moradi, A. Ghaemi, A. Javid, N. Talkhabifard, M. Naziri, H.

Cytomegalovirus Active Infection in Persons Infected with Human Immunodeficiency Virus

Ghaffari, H. (BSc)1, Moradi, A. (PhD)2, Ghaemi, A. (PhD)3, Javid, N. (MSc)4, Talkhabifard, M. (MSc)5, Naziri, H. (MSc)6, Tabaraei, A. (PhD)7

1. MSc Student of Medical Virology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran

2. Professor of Virology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran

3. Assistant Professor of Medical Virology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran

4. MSc of Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran

5. MSc of Medical Virology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran

6. MSc of Medical Virology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran

7. Assistant Professor of Virology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran

Background and Objective: Cytomegalovirus (CMV), one of the most common opportunistic pathogens in patients infected with human immunodeficiency virus (HIV), can cause the diseases such as encephalitis, pneumonia, and chorioretinitis. This study aimed at molecular studying of CMV infection in individuals infected with the human immunodeficiency virus.

Material and Methods: In this study, 50 venous blood samples from HIV-infected individuals were taken. Patients were divided into two categories: patients under treatment with and without antiretroviral drugs. Plasma were separated from blood samples and examined for the presence of cytomegalovirus genome by PCR.

Material and Methods: this study was conducted on 50 blood samples from HIV-infected individuals, and plasma was separated and examined for the presence of cytomegalovirus genome by PCR. Patients were divided into two group of under treatment with and without antiretroviral drugs.

Results: Of 50, 28 (% 56) were men and 22 (% 44) were women. CMV genome was identified in 8 samples (16%), and the molecular prevalence of CMV infection was 21.4% (n= 6) in males and 9.1% (n = 2) in females.

Conclusion: Given the frequency of Cytomegalovirus Active Infection in HIV-infected individuals under antiretroviral therapy, we should be careful about the treatment of Cytomegalovirus Active Infection.

Keywords: Active Infection, Cytomegalovirus, Human Immunodeficiency Virus, Shiraz, PCR

Corresponding Author: Tabaraei, A.

Email: Alijant@yahoo.com

Received: 24 Dec 2013
Revised: 18 Apr 2014
Accepted: 28 Apr 2014