This paper should be cited as:Rafeemehr,H.
Rafeemehr, H. (PhD)*1
1. Assistant Professor of Hematology,
Department of Medical Laboratory Sciences, Faculty of Paramedicine,
Hamedan University of Medical Sciences, Hamedan, Iran
Abstract
Background and Objective:Glutathione as a master antioxidant plays a key role in eliminating
free radicals from your body and in preserving cell membrane integrity esp.blood cells.We aimed to
assess the Erythrocyte Glutathione
level of favism
and non-favism neonates.
Material and Methods: This study was conducted in Ekbatan
hospitals of Hamadan (2009) on 15 favism patients and
60 non-favism ones matched by sex and age.Using Beutler method,
the reduced Glutathione (GSH) level of red blood cells was
measured.
Results:Based on the results, the amount of erythrocyte GSH in favism patients was 14.99±4.62 mg/dl and that of controls was 58.2±10.59 mg/dl.
Conclusion:the results show that the erythrocyte GSH in favism patients is significantly lower than that of non-favism subjects; therefore, the former seems more likely to be afflicted by hemolytic crises owing to the use of oxidant stuff.
Keywords:Favism;Glutathone;Neonates;G6PD
Corresponding author: Rafeemehr, H.
Email: rafee_1352@yahoo.com
Received 29
Dec 2012 Revised 30 May 2013 Accepted 1 Jun 2013