This paper should be cited as: Shojaee, M. Farzanegi, P. Habibian, M.
Effect of Regular Aerobic Training and
Arbutin on Cardiac Total Oxidant and Antioxidant
Status in Alloxan-Induced Diabetic Rat
Shojaee, M. (MSc)1,Farzanegi, P. (PhD)2, Habibian, M. (PhD)3
1. MSc of Sport Physiology, Islamic Azad University, Sari Branch, Iran
2. Assistant Professor of Sport Physiology, Islamic Azad University, sari Branch,
sari
3. Assistant Professor of Sport
Physiology, Islamic Azad University, Qaemshahar
Branch, Iran
Abstract
Background and Objective: Diabetes mellitus is associated with cardiomyopathic
changes, can be mediated by an oxidative stress. We aimed to study the effects of regular
aerobic training and arbutin supplementation on total
oxidant status (TOS) and total antioxidant (TAS) status in the cardiac tissue
of diabetic rats.
Material and Methods: fourty-two male Wistar
rats with an average weight of 195 to 220 gr were randomly divided into 6
groups (7 rats per group) of control, diabetes, Arbutin,
diabetes + Arbutin, diabetes + aerobic training and diabetes
+ aerobic training + Arbutin. Swimming training protocol consisted of 5
days/week for 6 weeks and each session was 5-36 min/day. Diabetes was induced
with alloxan intraperitoneally
and Arbutin (50 mg/kg) was administered
subcutaneously.
Results: Induced- diabetes significantly increased TOS and decreased TAS in
rat heart tissue (P = 0.000). Six weeks of supplementation with Arbutin, aerobic training and combination of aerobic
training and Arbutin supplementation were associated
with a significant decrease in TOS (88%, 91% ,103% Respectively ) and
increase in TAS (33% ,62% ,67% Respectively ).
Conclusion: Compared to arbutin, aerobic training
can be more effective in creating adaptation in the antioxidant defense system.
Keywords: Aerobic Training, Arbutin, Total Oxidant Status, Total Antioxidant Status,
Diabetes.
Corresponding Author: Shojaee, M.
Email: Shojaee.mostafa@hotmail.com
Received: 23
Apr 2014
Revised: 9 May 2014
Accepted: 11 May 2014
This paper should be cited as: Shojaee M,
Farzanegi P, Habibian M. [Effect
of Regular Aerobic Training and Arbutin on Cardiac
Total Oxidant and Antioxidant Status in Alloxan-Induced
Diabetic Rat]. mljgoums. 2015;
9(1): 76-83[Article in Persian]