Rapid Diagnosis of acute kidney injury (AKI) associated with cardiac surgery, using the liver type fatty acid binding protein (L-FABP) biomarker

Mirbagheri M,; Taghipour H R,; Farhadi N,; Mirbagheri L,; Imani Foladi AA,; Nourani M R,

Volume 6, Issue 1 (spring-summer[PERSIAN] 2012) mljgoums 2012, 6(1): 43-50 | Back to browse issues page

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Mirbagheri M, Taghipour H R, Farhadi N, Mirbagheri L, Imani Foladi AA, Nourani M R. Rapid Diagnosis of acute kidney injury (AKI) associated with cardiac surgery, using the liver type fatty acid binding protein (L-FABP) biomarker. mljgoums 2012; 6 (1) :43-50
URL: http://mlj.goums.ac.ir/article-1-196-en.html

Rapid Diagnosis of acute kidney injury (AKI) associated with cardiac surgery, using the liver type fatty acid binding protein (L-FABP) biomarker

Mirbagheri M¹

, Taghipour H R

, Farhadi N²

, Mirbagheri L³

, Imani Foladi AA

, Nourani M R

⁴

1- Baghi Yatallah University of Medical Sciences,
2- Nano-Biotechnology Research Center,
3- Science and Research Branch
4- Chemical Injuries Research Center , r.nourani@yahoo.com

Abstract: (18031 Views)

Abstract Background and objectives: cardiac surgery is often associated with acute kidney injury (AKI). Nowadays, AKI is typically diagnosed by an increase in serum creatinine, which is a delayed and unreliable biomarker. Recent studies recommended using the liver type fatty acid binding protein (L-FABP) as an early biomarker. Material and Methods: The urine samples of 18 adult patients undergoing cardiac surgery were collected in different times before (2, 4,8,24 hour) and after cardiac surgery for detection of L-FABP by Elisa. Results: The results from ELISA test show that the increasing amount of L-FABP in urine samples of 4 patients is a diagnostic indicator for AKI. The mean concentration of L-FABP has increased up to 17 times at 8 hours after cardiac surgery compared to before surgery. Conclusion: according to our findings, we speculated that the urinary L-FABP can be a reliable and rapid biomarker for diagnosis of acute kidney injury. Key words: Acute Kidney Injury, Liver type Fatty Acid Binding Protein, Cardiac surgery

Keywords: Acute Kidney Injury, Liver type Fatty Acid Binding Protein, Cardiac surgery

Full-Text [PDF 211 kb] [English Abstract] (7770 Downloads)

Research Article: Original Paper |
Received: 2012/08/1 | Accepted: 2014/01/12 | Published: 2014/01/12 | ePublished: 2014/01/12