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mljgoums 2022, 16(6): 40-44 |
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Astagimath M, Doddamani S, Patil V, Aryapu R. Anti-SARS-CoV-2 IgG Response after First and Second Dose of COVID-19 Vaccine. mljgoums 2022; 16 (6) :40-44
URL: http://mlj.goums.ac.ir/article-1-1497-en.html
URL: http://mlj.goums.ac.ir/article-1-1497-en.html
1- Department of Biochemistry, Karnataka Institute of Medical Sciences, Hubballi, Karnataka, India
2- Department of Biochemistry, Karnataka Institute of Medical Sciences, Hubballi Karnataka, India
3- Assistant Professor,Department of General Medicine, Karnataka Institute of medical sciences, Hubballi, Karnataka, India. , vcpatil2009@gmail.com
4- Department of General Medicine, Karnataka Institute of medical sciences, Hubballi, Karnataka, India
2- Department of Biochemistry, Karnataka Institute of Medical Sciences, Hubballi Karnataka, India
3- Assistant Professor,Department of General Medicine, Karnataka Institute of medical sciences, Hubballi, Karnataka, India. , vcpatil2009@gmail.com
4- Department of General Medicine, Karnataka Institute of medical sciences, Hubballi, Karnataka, India
Abstract: (1926 Views)
Background and objectives: Pandemics have serious adverse impacts on public health, economy, social structure, and overall growth and development of a nation. Such impacts can be mitigated by timely introduction of effective vaccination programs. This was successfully achieved in India. This study was performed to compare the anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) responses after first and second dose of coronavirus disease 2019 (COVID-19) vaccination.
Methods: This cross-sectional study included 60 people who were vaccinated with the AstraZeneca vaccine at Karnataka Institute of Medical Sciences, Hubballi, India. The subjects were divided into two groups. Group I included 30 people who had received a single dose of the vaccine, and group II included 30 people who had received two doses of the vaccine. Exclusion criteria included having a history of influenza like illness/severe acute respiratory infection/proven COVID-19 infection in past 6 months. The antibody response was measured by the Anti-SARS-CoV-2 IgG test using the VITROS Anti-SARS-CoV-2 IgG Reagent Pack.
Results: We observed that 97% of the subjects had reactive IgG antibodies after receiving two doses of the vaccine, whereas only 83% of the subjects developed antibodies after a single dose of the vaccine. A positive correlation was observed between the development of reactive antibodies and the duration between the first dose and the second dose (r=0.24).
Conclusion: Based on the results, the two-dose vaccination with the AstraZeneca vaccine is beneficial over the single-dose vaccination for protection against COVID-19. Moreover, increasing the duration between doses might improve the antibody response.
Methods: This cross-sectional study included 60 people who were vaccinated with the AstraZeneca vaccine at Karnataka Institute of Medical Sciences, Hubballi, India. The subjects were divided into two groups. Group I included 30 people who had received a single dose of the vaccine, and group II included 30 people who had received two doses of the vaccine. Exclusion criteria included having a history of influenza like illness/severe acute respiratory infection/proven COVID-19 infection in past 6 months. The antibody response was measured by the Anti-SARS-CoV-2 IgG test using the VITROS Anti-SARS-CoV-2 IgG Reagent Pack.
Results: We observed that 97% of the subjects had reactive IgG antibodies after receiving two doses of the vaccine, whereas only 83% of the subjects developed antibodies after a single dose of the vaccine. A positive correlation was observed between the development of reactive antibodies and the duration between the first dose and the second dose (r=0.24).
Conclusion: Based on the results, the two-dose vaccination with the AstraZeneca vaccine is beneficial over the single-dose vaccination for protection against COVID-19. Moreover, increasing the duration between doses might improve the antibody response.
Research Article: Original Paper |
Subject:
Immunology
Received: 2022/03/16 | Accepted: 2022/06/1 | Published: 2022/09/6 | ePublished: 2022/09/6
Received: 2022/03/16 | Accepted: 2022/06/1 | Published: 2022/09/6 | ePublished: 2022/09/6
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